References of "Bastin, Christine"
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See detailControlled and automatic memory retrieval in Alzheimer's disease
Bastin, Christine ULg

Conference (2013, February 28)

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See detailImpairment of two memory cerebral networks in Alzheimer's disease
Bastin, Christine ULg; Bahri, Mohamed Ali ULg; Collette, Fabienne ULg et al

in Proceedings of the Annual Meeting of the Belgian Association for Psychological Sciences (2013)

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See detailCognitive reserve, recollection and familiarity in normal aging, Mild Cognitive Impairment and Alzheimer's disease
Laisney, Mickaël; Salmon, Eric ULg; Bastin, Christine ULg

in Proceedings of the Annual Meeting of the Belgian Association for Psychological Sciences (2013)

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See detailEffects of aging on task- and stimulus-related attention during a working memory task
Kurth, Sophie ULg; Hagelstein, Catherine ULg; Collette, Fabienne ULg et al

in Proceedings of the Annual Meeting of the Belgian Association for Psychological Sciences (2013)

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See detailThe role of memory traces quality in directed forgetting: A comparison of young and elderly participants using the item procedure
Lorant; Grandjean, Julien; Bastin, Christine ULg et al

in Proceedings of the Annual Meeting of the Belgian Association for Psychological Sciences (2013)

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See detailClassification of positron emission tomography images using multiple kernel learning
Segovia-Román, Fermín ULg; Bastin, Christine ULg; Salmon, Eric ULg et al

in Proceeding of 3rd NIPS 2013 Workshop on Machine Learning and Interpretation in NeuroImaging (2013)

Over the last years, several approaches to analyze nuclear medicine imaging using computer systems have been proposed with the aim of assisting the diagnosis of neurodegenerative disorders. Probably one ... [more ▼]

Over the last years, several approaches to analyze nuclear medicine imaging using computer systems have been proposed with the aim of assisting the diagnosis of neurodegenerative disorders. Probably one of the most complex challenges facing these approaches is to deal with the huge amount of data provided by brain images. In this work, we propose an original approach based on multiple kernel learning. First the images were parcellated (according to the structure of the brain) by means of the automatic anatomical labeling atlas. Then, the importance of each region for the assisted diagnosis was estimated using a classifi- cation procedure. Finally, all the regions were combined in a multiple kernel method in which one kernel per region was computed and all the kernels were weighted according to the importance of the region they represented. For testing purposes, a database with 46 PET images from stable mild cognitive impairment subjects and early Alzheimer’s disease converter patients was used. An accuracy rate of 73.91% was achieved when differentiating between both groups. [less ▲]

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See detailDifferential effects of aging on the neural correlates of recollection and familiarity
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2013), 49

The present experiment aimed to investigate age differences in the neural correlates of familiarity and recollection, while keeping performance similar across age groups by varying task difficulty. Twenty ... [more ▼]

The present experiment aimed to investigate age differences in the neural correlates of familiarity and recollection, while keeping performance similar across age groups by varying task difficulty. Twenty young and twenty older adults performed an episodic memory task in an event-related fMRI design. At encoding, participants were presented with pictures, either once or twice. Then, they performed a recognition task, with a Remember/Know paradigm. A similar performance was observed for the two groups in the Easy condition for recollection and in the Hard condition for familiarity. Imaging data revealed the classic recollection-related and familiarity-related networks, common to young and older groups. In addition, we observed that some activity related to recollection (left frontal, left temporal, left parietal cortices and left parahippocampus) and familiarity (bilateral anterior cingulate, right frontal gyrus and left superior temporal gyrus) was reduced in older compared to young adults. However, for recollection processes only, older adults additionally recruited the right precuneus, possibly to successfully compensate for their difficulties, as suggested by a positive correlation between recollection and precuneus activity. [less ▲]

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See detailClassification of MCI and AD patients combining PET data and psychological scores
Segovia-Román, Fermín ULg; Bastin, Christine ULg; Salmon, Eric ULg et al

in International Workshop on Advances in Regularization, Optimization, Kernel Methods and Support Vector Machines: theory and applications (2013)

This study’s aim was to measure the advantages of using psychological test data in the automatic classification of functional brain images in order to assist the diagnosis of neurodegenerative disorders ... [more ▼]

This study’s aim was to measure the advantages of using psychological test data in the automatic classification of functional brain images in order to assist the diagnosis of neurodegenerative disorders such as Alzheimer’s disease (AD). Several computer-aided diagnosis systems for AD based on PET images were developed. Some of them used psychological scores beside the image data in the classification step and others did not. The results show the ones that take into account the psychological scores achieve higher accuracy rates. [less ▲]

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See detailAutomatic differentiation between Alzheimer’s Disease and Mild Cognitive Impairment combining PET data and psychological scores
Segovia-Román, Fermín ULg; Bastin, Christine ULg; Salmon, Eric ULg et al

in 3rd International Workshop on Pattern Recognition in Neuroimaging (2013)

In recent years, several approaches to develop computer aided diagnosis systems for dementia have been pro- posed. The purpose of this work is to measure the advantages of using not only brain images as ... [more ▼]

In recent years, several approaches to develop computer aided diagnosis systems for dementia have been pro- posed. The purpose of this work is to measure the advantages of using not only brain images as data source for those systems but also some psychological scores. To this aim, we compared the accuracy rates achieved by systems that use psychological scores beside the image data in the classification step and systems that use only the image data. The experiments show that the formers achieve higher accuracy rates regardless of the procedure carried out to analyze the image data. [less ▲]

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See detailMetabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults
Yakushev, Igor; Chételat, Gael; Fischer F.U. et al

in NeuroImage (2013), 79

Studies of functional connectivity suggest that the default mode network (DMN) might be relevant for cognitive functions. Here, we examined metabolic and structural connectivity between major DMN nodes ... [more ▼]

Studies of functional connectivity suggest that the default mode network (DMN) might be relevant for cognitive functions. Here, we examined metabolic and structural connectivity between major DMN nodes, the posterior cingulate (PCC) and medial prefrontal cortex (MPFC), in relation to normal working memory (WM). DMN was captured using independent component analysis of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) data from 35 young healthy adults (27.1±5.1 years). Metabolic connectivity, a correlation between FDG uptake in PCC and MPFC, was examined in groups of subjects with (relative to median) low (n=18) and high (n=17) performance on digit span backward test as an index of verbal WM. In addition, fiber tractography based on PCC and MPFC nodes as way points was performed in a subset of subjects. FDG uptake in the DMN nodes did not differ between high and low performers. However, significantly (p=0.01) lower metabolic connectivity was found in the group of low performers. Furthermore, as compared to high performers, low performers showed lower density of the left superior cingulate bundle. Verbal WM performance is related to metabolic and structural connectivity within the DMN in young healthy adults. Metabolic connectivity as quantified with FDG-PET might be a sensitive marker of the normal variability in some cognitive functions. [less ▲]

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See detailRelationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity
Chételat, Gael; Landeau, Brigitte; Salmon, Eric ULg et al

in NeuroImage (2013), 76

Normal aging is characterized by brain glucose metabolism decline predominantly in the prefrontal cortex. The goal of the present study was to assess whether this change was associated with age-related ... [more ▼]

Normal aging is characterized by brain glucose metabolism decline predominantly in the prefrontal cortex. The goal of the present study was to assess whether this change was associated with age-related alteration of white matter (WM) structural integrity and/or functional connectivity. FDG-PET data from 40 young and 57 elderly healthy participants from two research centres (n=49/48 in Centre 1/2) were analyzed. WM volume from T1-weighted MRI (Centre 1), fractional anisotropy from diffusion-tensor imaging (Centre 2), and resting-state fMRI data (Centre 1) were also obtained. Group comparisons were performed within each imaging modality. Then, positive correlations were assessed, within the elderly, between metabolism in the most affected region and the other neuroimaging modalities. Metabolism decline in the elderly predominated in the left inferior frontal junction (LIFJ). LIFJ hypometabolism was significantly associated with macrostructural and microstructural WM disturbances in long association fronto-temporo-occipital fibers, while no relationship was found with functional connectivity. The findings offer new perspectives to understand normal aging processes and open avenues for future studies to explore causality between age-related metabolism and connectivity changes. [less ▲]

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See detailImpairments of 3D visual perception in posterior cortical atrophy: functional and anatomical characterization
Gillebert, Céline; Bastin, Christine ULg; Sunaert, Stefan et al

Conference (2013)

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See detailEpisodic autobiographical memory in amnestic Mild Cognitive Impairment: What are the neural correlates?
Bastin, Christine ULg; Feyers, Dorothée ULg; Jedidi, Haroun ULg et al

in Human Brain Mapping (2013), 34

Autobiographical memory in amnestic Mild Cognitive Impairment (aMCI) is characterized by impaired retrieval of episodic memories, but relatively preserved personal semantic knowledge. This study aimed to ... [more ▼]

Autobiographical memory in amnestic Mild Cognitive Impairment (aMCI) is characterized by impaired retrieval of episodic memories, but relatively preserved personal semantic knowledge. This study aimed to identify (via FDG-PET) the neural substrates of impaired episodic specificity of autobiographical memories in 35 aMCI patients compared with 24 healthy elderly controls. Significant correlations between regional cerebral activity and the proportion of episodic details in autobiographical memories from two life periods were found in specific regions of an autobiographical brain network. In aMCI patients, more than in controls, specifically episodic memories from early adulthood were associated with metabolic activity in the cuneus and in parietal regions. We hypothesized that variable retrieval of episodic autobiographical memories in our aMCI patients would be related to their variable capacity to reactivate specific sensory-perceptual and contextual details of early adulthood events linked to reduced (occipito-parietal) visual imagery and less efficient (parietal) attentional processes. For recent memories (last year), a correlation emerged between the proportion of episodic details and activity in lateral temporal regions and the temporo-parietal junction. Accordingly, variable episodic memory for recent events may be related to the efficiency of controlled search through general events likely to provide cues for the retrieval of episodic details and to the ability to establish a self perspective favouring recollection. [less ▲]

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See detailItem familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study
Genon, Sarah ULg; Collette, Fabienne ULg; Feyers, Dorothée ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2013), 49

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See detailFonctionnement mnésique et maladie d’Alzheimer
Salmon, Eric ULg; Bastin, Christine ULg

in Lettre des Académies (La) (2013), 29

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

in Journal of Psychophysiology (2013), 27(Suppl 1), 48

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

Poster (2013)

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