References of "Bastin, Christine"
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See detailAge estimation from faces in Alzheimer disease
Moyse, Evelyne ULg; Brédart, Serge ULg; Salmon, Eric ULg et al

Poster (2013, July)

Although studies on age estimation showed that the performance of estimation is fairly accurate, this performance can be influenced by group biases such as the own-age bias (George & Hole, 1995). Moreover ... [more ▼]

Although studies on age estimation showed that the performance of estimation is fairly accurate, this performance can be influenced by group biases such as the own-age bias (George & Hole, 1995). Moreover this bias occurs both in young and older adults (Moyse & Brédart, 2012). Because difficulties in face processing have been reported in Alzheimer disease (Della Sala et al., 1995), the aim of this study was to examine the performance of age estimation from faces in patients with Alzheimer disease (mild to moderate) compared with normal aging persons. Moreover to test the preservation of the occurrence of an own-age bias, stimuli belonging to different age groups (young, middle age and older adults) were used. We observed a main effect of Group indicating that patients were less accurate than control whatever the age of faces. In addition a main effect of Age of faces was obtained; the percentage of accuracy was better for older faces than for the two other age groups of faces. Consequently although patients’ performance in age estimation of faces is impaired, an own-age bias was still present. These results have two main interests: a clinical interest (expanding the diagnostic criteria of the Alzheimer disease) and a forensic interest (assessing the credibility of eyewitness testimony in older adults with a possible Alzheimer disease). [less ▲]

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See detailBrain metabolic dysfunction in Capgras syndrome during Alzheimer’s disease: a positron emission tomography study
Jedidi, Haroun ULg; Daury, Noémy; Cappa, Rémi et al

Poster (2013, June)

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See detailControlled and automatic memory retrieval in Alzheimer's disease
Bastin, Christine ULg

Conference (2013, February 28)

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See detailImpairment of two memory cerebral networks in Alzheimer's disease
Bastin, Christine ULg; Bahri, Mohamed Ali ULg; Collette, Fabienne ULg et al

in Proceedings of the Annual Meeting of the Belgian Association for Psychological Sciences (2013)

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See detailCognitive reserve, recollection and familiarity in normal aging, Mild Cognitive Impairment and Alzheimer's disease
Laisney, Mickaël; Salmon, Eric ULg; Bastin, Christine ULg

in Proceedings of the Annual Meeting of the Belgian Association for Psychological Sciences (2013)

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See detailEffects of aging on task- and stimulus-related attention during a working memory task
Kurth, Sophie ULg; Hagelstein, Catherine ULg; Collette, Fabienne ULg et al

in Proceedings of the Annual Meeting of the Belgian Association for Psychological Sciences (2013)

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See detailThe role of memory traces quality in directed forgetting: A comparison of young and elderly participants using the item procedure
Lorant; Grandjean, Julien; Bastin, Christine ULg et al

in Proceedings of the Annual Meeting of the Belgian Association for Psychological Sciences (2013)

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See detailClassification of positron emission tomography images using multiple kernel learning
Segovia-Román, Fermín ULg; Bastin, Christine ULg; Salmon, Eric ULg et al

in Proceeding of 3rd NIPS 2013 Workshop on Machine Learning and Interpretation in NeuroImaging (2013)

Over the last years, several approaches to analyze nuclear medicine imaging using computer systems have been proposed with the aim of assisting the diagnosis of neurodegenerative disorders. Probably one ... [more ▼]

Over the last years, several approaches to analyze nuclear medicine imaging using computer systems have been proposed with the aim of assisting the diagnosis of neurodegenerative disorders. Probably one of the most complex challenges facing these approaches is to deal with the huge amount of data provided by brain images. In this work, we propose an original approach based on multiple kernel learning. First the images were parcellated (according to the structure of the brain) by means of the automatic anatomical labeling atlas. Then, the importance of each region for the assisted diagnosis was estimated using a classifi- cation procedure. Finally, all the regions were combined in a multiple kernel method in which one kernel per region was computed and all the kernels were weighted according to the importance of the region they represented. For testing purposes, a database with 46 PET images from stable mild cognitive impairment subjects and early Alzheimer’s disease converter patients was used. An accuracy rate of 73.91% was achieved when differentiating between both groups. [less ▲]

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See detailDifferential effects of aging on the neural correlates of recollection and familiarity
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2013), 49

The present experiment aimed to investigate age differences in the neural correlates of familiarity and recollection, while keeping performance similar across age groups by varying task difficulty. Twenty ... [more ▼]

The present experiment aimed to investigate age differences in the neural correlates of familiarity and recollection, while keeping performance similar across age groups by varying task difficulty. Twenty young and twenty older adults performed an episodic memory task in an event-related fMRI design. At encoding, participants were presented with pictures, either once or twice. Then, they performed a recognition task, with a Remember/Know paradigm. A similar performance was observed for the two groups in the Easy condition for recollection and in the Hard condition for familiarity. Imaging data revealed the classic recollection-related and familiarity-related networks, common to young and older groups. In addition, we observed that some activity related to recollection (left frontal, left temporal, left parietal cortices and left parahippocampus) and familiarity (bilateral anterior cingulate, right frontal gyrus and left superior temporal gyrus) was reduced in older compared to young adults. However, for recollection processes only, older adults additionally recruited the right precuneus, possibly to successfully compensate for their difficulties, as suggested by a positive correlation between recollection and precuneus activity. [less ▲]

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See detailClassification of MCI and AD patients combining PET data and psychological scores
Segovia-Román, Fermín ULg; Bastin, Christine ULg; Salmon, Eric ULg et al

in International Workshop on Advances in Regularization, Optimization, Kernel Methods and Support Vector Machines: theory and applications (2013)

This study’s aim was to measure the advantages of using psychological test data in the automatic classification of functional brain images in order to assist the diagnosis of neurodegenerative disorders ... [more ▼]

This study’s aim was to measure the advantages of using psychological test data in the automatic classification of functional brain images in order to assist the diagnosis of neurodegenerative disorders such as Alzheimer’s disease (AD). Several computer-aided diagnosis systems for AD based on PET images were developed. Some of them used psychological scores beside the image data in the classification step and others did not. The results show the ones that take into account the psychological scores achieve higher accuracy rates. [less ▲]

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See detailAutomatic differentiation between Alzheimer’s Disease and Mild Cognitive Impairment combining PET data and psychological scores
Segovia-Román, Fermín ULg; Bastin, Christine ULg; Salmon, Eric ULg et al

in 3rd International Workshop on Pattern Recognition in Neuroimaging (2013)

In recent years, several approaches to develop computer aided diagnosis systems for dementia have been pro- posed. The purpose of this work is to measure the advantages of using not only brain images as ... [more ▼]

In recent years, several approaches to develop computer aided diagnosis systems for dementia have been pro- posed. The purpose of this work is to measure the advantages of using not only brain images as data source for those systems but also some psychological scores. To this aim, we compared the accuracy rates achieved by systems that use psychological scores beside the image data in the classification step and systems that use only the image data. The experiments show that the formers achieve higher accuracy rates regardless of the procedure carried out to analyze the image data. [less ▲]

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See detailMetabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults
Yakushev, Igor; Chételat, Gael; Fischer F.U. et al

in NeuroImage (2013), 79

Studies of functional connectivity suggest that the default mode network (DMN) might be relevant for cognitive functions. Here, we examined metabolic and structural connectivity between major DMN nodes ... [more ▼]

Studies of functional connectivity suggest that the default mode network (DMN) might be relevant for cognitive functions. Here, we examined metabolic and structural connectivity between major DMN nodes, the posterior cingulate (PCC) and medial prefrontal cortex (MPFC), in relation to normal working memory (WM). DMN was captured using independent component analysis of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) data from 35 young healthy adults (27.1±5.1 years). Metabolic connectivity, a correlation between FDG uptake in PCC and MPFC, was examined in groups of subjects with (relative to median) low (n=18) and high (n=17) performance on digit span backward test as an index of verbal WM. In addition, fiber tractography based on PCC and MPFC nodes as way points was performed in a subset of subjects. FDG uptake in the DMN nodes did not differ between high and low performers. However, significantly (p=0.01) lower metabolic connectivity was found in the group of low performers. Furthermore, as compared to high performers, low performers showed lower density of the left superior cingulate bundle. Verbal WM performance is related to metabolic and structural connectivity within the DMN in young healthy adults. Metabolic connectivity as quantified with FDG-PET might be a sensitive marker of the normal variability in some cognitive functions. [less ▲]

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