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See detailThe role of the salience of fluency in recognition memory in Alzheimer’s disease
Bastin, Christine ULg; Salmon, Eric ULg; Willems, Sylvie ULg

in Proceedings of the First joint meeting of the Belgian Association for Psychological Sciences (BAPS) and the Sociedad Española de Psicología Experimental (SEPEX) (2012)

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See detailDissociation entre recollection et familiarité dans la maladie d'Alzheimer : Etude des bases cérébrales en imagerie par résonance magnétique fonctionnelle.
Bastin, Christine ULg; Genon, Sarah ULg; Collette, Fabienne ULg et al

in Proceedings of the 11th Reunion Francophone sur la Maladie d’Alzheimer et les Syndromes Apparentés (2012)

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See detailNormal and pathological aging and memory
Bastin, Christine ULg

Scientific conference (2012)

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See detailEpisodic memory in normal aging and Alzheimer’s disease
Bastin, Christine ULg

Scientific conference (2012)

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See detailNeural bases of deficits of episodic memory in Alzheimer’s disease
Bastin, Christine ULg

Scientific conference (2012)

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See detailEpisodic memory in Alzheimer’s disease
Bastin, Christine ULg

Scientific conference (2012)

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See detailFrontal and posterior cingulate metabolic impairment in the behavioural variant of frontotemporal dementia with impaired autonoetic consciousness
Bastin, Christine ULg; Feyers, Dorothée ULg; Souchay, Céline et al

in Human Brain Mapping (2012), 33

Although memory dysfunction is not a prominent feature of the behavioural variant of frontotemporal dementia (bv-FTD), there is evidence of specific deficits of episodic memory in these patients. They ... [more ▼]

Although memory dysfunction is not a prominent feature of the behavioural variant of frontotemporal dementia (bv-FTD), there is evidence of specific deficits of episodic memory in these patients. They also have problems monitoring their memory performance. The objective of the present study was to explore the ability to consciously retrieve own encoding of the context of events (autonoetic consciousness) and the ability to monitor memory performance using feeling-of-knowing (FOK) in bv-FTD. Analyses of the patients’ cerebral metabolism (FDG-PET) allowed an examination of whether impaired episodic memory in bv-FTD is associated with the frontal dysfunction characteristic of the pathology or a dysfunction of memory-specific regions pertaining to Papez’s circuit. Data were obtained from 8 bv-FTD patients and 26 healthy controls. Autonoetic consciousness was evaluated by Remember responses during the recognition memory phase of the FOK experiment. As a group, bv-FTD patients demonstrated a decline in autonoetic consciousness and FOK accuracy at the chance level. While memory monitoring was impaired in most (7) patients, 4 bv-FTD participants had individual impairment of autonoetic consciousness. They specifically showed reduced metabolism in the anterior medial prefrontal cortex, the left dorsolateral prefrontal cortex (near the superior frontal sulcus), parietal regions and the posterior cingulate cortex. These findings were tentatively interpreted by considering the role of the metabolically impaired brain regions in self-referential processes, suggesting that the bv-FTD patients’ problem consciously retrieving episodic memories may stem at least partly from deficient access to and maintenance/use of information about the self. [less ▲]

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See detailAging effect on recollection and familiarity processes
Collette, Fabienne ULg; Angel, Lucie; Bastin, Christine ULg et al

Scientific conference (2011, December 22)

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See detailSleep contributes to the strengthening of some memories over others, depending on hippocampal activity at learning.
Rauchs, Géraldine; Feyers, Dorothée ULg; Landeau, Brigitte et al

in Journal of Neuroscience (2011), 31(7), 2563-2568

Memory consolidation benefits from sleep. Besides strengthening some memory traces, another crucial, albeit overlooked, function of memory is also to erase irrelevant information. Directed forgetting is ... [more ▼]

Memory consolidation benefits from sleep. Besides strengthening some memory traces, another crucial, albeit overlooked, function of memory is also to erase irrelevant information. Directed forgetting is an experimental approach consisting in presenting “to be remembered” and “to be forgotten” information, that allows selectively decreasing or increasing the strength of individual memory traces according to the instruction provided at learning. This paradigm was used in combination with fMRI to determine, in Humans, what specifically triggers at encoding sleep-dependent compared to time-dependent consolidation. Our data indicate that relevant items which subjects strived to memorize are consolidated during sleep to a greater extend than items that participants did not intend to learn. This process appears to depend on a differential activation of the hippocampus at encoding, which acts as a signal for the offline reprocessing of relevant memories during post-learning sleep episodes. [less ▲]

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See detailThe cerebral metabolic correlates of episodic autobiographical memory in amnestic Mild Cognitive Impairment
Bastin, Christine ULg; Feyers, Dorothée ULg; Jedidi, Haroun ULg et al

in Proceedings of the 5th International Conference on Memory (2011)

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See detailThe neural correlates of cognitive reserve in aging
Bastin, Christine ULg; Bahri, Mohamed Ali ULg; Collette, Fabienne ULg et al

Scientific conference (2011)

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See detailAssociative memory in Alzheimer’s disease
Bastin, Christine ULg

Scientific conference (2011)

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See detailNeural correlates of controlled memory processes in questionable Alzheimer’s disease
Bastin, Christine ULg; Kerrouche, Nacer; LEKEU, Françoise ULg et al

in Ashford, J. Wesson; Rosen, Allyson; Adamson, Maheen (Eds.) et al Advances in Alzheimer's Disease. Volume 2: Handbook of imaging the Alzheimer brain (2011)

Alzheimer’s disease (AD) is characterized by a progressive loss of controlled cognitive processes (processes requiring mental effort and attentional resources), and functional neuroimaging at early stages ... [more ▼]

Alzheimer’s disease (AD) is characterized by a progressive loss of controlled cognitive processes (processes requiring mental effort and attentional resources), and functional neuroimaging at early stages of AD provides an opportunity to tease out the neural correlates of controlled processes. Controlled and automatic memory performance was assessed with the Process Dissociation Procedure in 50 patients diagnosed with questionable Alzheimer’s disease (QAD). The patients’ brain glucose metabolism was measured using FDG-PET. After a follow-up period of 36 months, 27 patients had converted to AD, while 23 remained stable. Both groups showed a similar decrease in controlled memory processes but preserved automatic processes at entry into the study, suggesting that impairment of controlled memory would not be specific for AD. Patients who subsequently converted to Alzheimer type dementia showed significantly decreased brain metabolism at baseline compared to stable QAD in associative cortices known to be involved in AD (the left precuneus, the right inferior parietal lobule and bilateral middle temporal cortex).Voxel-based cognitive and metabolic correlations showed that a decrease in controlled memory processes was preferentially correlated with lower activity in the dorsomedial prefrontal and posterior cingulate cortices in very early AD patients. The dorsomedial prefrontal cortex would play a role in controlled memory processes as they relate to reflective and monitoring processes, while the posterior cingulate cortex is involved in the controlled access to previously encoded episodes. In stable QAD patients, reduced controlled performance in verbal memory correlated with impaired activity in the left anterior hippocampal structure, which would alter the reactivation of associations created at encoding. [less ▲]

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See detailRecollection and familiarity processes in probable Alzheimer's disease: an fMRI study
Genon, Sarah ULg; Collette, Fabienne ULg; Salmon, Eric ULg et al

in Proceedings of the 5th International Conference on Memory (2011)

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during ... [more ▼]

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during performance of a recognition memory task with the process dissociation procedure. Brain regions associated to recollection were evidenced by contrasting activations for inclusion and exclusion conditions whereas brain regions related to familiarity were explored with the mean effect of the two conditions (at P < .05 corrected). Twelve patients had null recollection estimates (AD-), whereas 16 patients did experience some recollection although significantly less than controls (AD+). In AD+ and controls, recollection activated the posterior cingulate cortex (PCC). In contrast, familiarity estimates were equivalent in the 3 groups and were associated with brain activations around the intraparietal sulcus (IPS). Thus, in AD, impaired recollection is related to damage of the PCC whereas preserved familiarity is supported by the IPS. [less ▲]

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