References of "Bastin, Christine"
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See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULg; Simon, Jessica ULg; Bahri, Mohamed Ali ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (in press)

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

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See detailSelf in Dementia
Antoine, Nicolas ULg; Genon, Sarah ULg; Bastin, Christine ULg et al

in Mishara; Corlett, P.; Fletcher, P. (Eds.) et al Phenomenological Neuropsychiatry, How Patient Experience Bridges Clinic with Clinical Neuroscience (in press)

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See detailIncreasing the salience of fluency cues does not reduce the recognition memory impairment in Alzheimer’s disease!
Simon, Jessica ULg; Bastin, Christine ULg; SALMON, Eric ULg et al

in Journal of Neuropsychology (in press)

In Alzheimer’s disease (AD), it is now well established that recollection is impaired from the beginning of the disease, whereas findings are less clear concerning familiarity. One of the most important ... [more ▼]

In Alzheimer’s disease (AD), it is now well established that recollection is impaired from the beginning of the disease, whereas findings are less clear concerning familiarity. One of the most important mechanisms underlying familiarity is the sense of familiarity driven by processing fluency. In this study, we attempted to attenuate recognition memory deficits in AD by maximizing the salience of fluency cues in two conditions of a recognition memory task. In one condition, targets and foils have been created from the same pool of letters (Overlap condition). In a second condition, targets and foils have been derived from two separate pools of letters (No-Overlap condition), promoting the use of letter-driven visual and phonetic fluency. Targets and foils were low-frequency words. The memory tasks were performed by 15 patients with AD and 16 healthy controls. Both groups improved their memory performance in the No-Overlap condition compared to the Overlap condition. Patients with AD were able to use fluency cues during recognition memory as older adults did, but this did not allow to compensate for dysfunction of recognition memory processes. [less ▲]

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULg; Blanpain, Manon ULg; Van Egroo, Maxime ULg et al

Poster (2017, March 23)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Methods. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35, while there were no significant correlations in the right hemisphere. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region, what is more contradictory according to the current literature. No significant link was found between BPS and the volume of hippocampal subfields in the left hemisphere. Conclusion. In a middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects [less ▲]

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See detailImpaired familiarity in individuals at risk for Alzheimer's disease: Commentary on Schoemaker et al. (2016)
Bastin, Christine ULg; Besson, Gabriel ULg

in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (2017), 6

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See detailL’impact des connaissances sémantiques préexistantes en mémoire associative dans le vieillissement normal
Folville, Adrien ULg; Delhaye, Emma ULg; Bastin, Christine ULg

in Revue de Neuropsychologie, Neurosciences Cognitives et Cliniques (2016), 8(4), 253-260

The formation of a global and complex episodic memory requires memory for single units of information of the target event but also binding these elements together. This binding capacity diminishes in ... [more ▼]

The formation of a global and complex episodic memory requires memory for single units of information of the target event but also binding these elements together. This binding capacity diminishes in healthy aging leading to a so-called associative memory deficit. Interestingly, when support is provided during encoding thanks to semantic prior-knowledge (e.g., semantically related word pairs), this associative deficit can be alleviated. The aim of the present review is to summarize the current literature about the influence of prior-knowledge on associative memory performance in healthy aging. Through an analysis of the procedures that have been used in associative memory studies, we suggest two factors that appear to modulate the impact of prior knowledge on older adults’ associative memory. First, the way word pairs are recombined from the encoding to the retrieval phase is the main factor that has to be taken into account. Conditions that promote recall-to-reject discrimination processes lead to similar performance in older compared to younger adults, whereas conditions that require recollection discrimination lead to an age-related decline. Second, the nature of the semantic relations involved in the prior-knowledge support may influence older adults’ performance by modulating the contribution of recollection and familiarity to recognition. Indeed, categorical semantic relations engage both recollection and familiarity-based discrimination, whereas thematic relations allow participants to rely on familiarity-based discrimination only. This latest observation is crucial when one considers recollection as a declining process, in contrast to familiarity, which remains spared in healthy aging. Therefore, future studies should explore the propensity of other semantic relations to alleviate the age-related associative memory decline. [less ▲]

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See detailImpact du nombre d’alternatives lors d’une tâche de reconnaissance à choix-forcé sur les processus de reconnaissance dans le vieillissement normal
Simon, Jessica ULg; Gilsoul, Jessica ULg; Bastin, Christine ULg

Poster (2016, September 19)

Les tâches de reconnaissance à choix forcé sont classiquement utilisées pour évaluer la mémoire de reconnaissance. Cependant, aucune étude n’a spécifiquement investigué l’impact du nombre d’alternatives ... [more ▼]

Les tâches de reconnaissance à choix forcé sont classiquement utilisées pour évaluer la mémoire de reconnaissance. Cependant, aucune étude n’a spécifiquement investigué l’impact du nombre d’alternatives sur les performances mnésiques des participants âgés. Nous voulons déterminer, d’une part, si le nombre d’alternatives proposées - deux ou trois – et d’autre part, si le degré de similarité entre la cible et ses leurres ont un impact sur les stratégies de récupération mises en place au cours de la tâche. Pour ce faire, nous avons recruté 20 participants jeunes et 20 participants âgés. Lors de la tâche de reconnaissance, nous leur avons demandé de choisir, parmi deux ou trois photographies de visages, celui qui a été présenté précédemment. Certains couples cibles-leurres étaient plus similaires que d’autres (partage de 60% de caractéristiques communes, contre 40%). Pour chaque item sélectionné, les participants devaient expliquer ce qui a guidé leur choix. Les premières analyses (ANOVA à mesures répétées 2 (groupes) x 2 (alternatives) x 2 (similarité) sur les deux dernières mesures, p<0,05) montrent que les performances entre les groupes sont équivalentes pour la tâche de reconnaissance à deux alternatives. A l’inverse, nous avons observé que les participants jeunes avaient significativement de meilleures performances que les âgés dans la tâche de reconnaissance à trois alternatives. Les profils mnésiques des participants seront étudiés à la lumière des modèles à deux processus de la reconnaissance. Nous faisons l’hypothèse d’un recours plus fréquent à la recollection chez les jeunes dans la tâche de reconnaissance à trois alternatives (vs deux alternatives), alors que le choix de l’item se ferait chez les âgés, en comparant directement les degrés de familiarité associés à chaque item et en sélectionnant le plus familier (Norman & O’Reilly, 2003). [less ▲]

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See detailEffects of aging on task- and stimulus-related cerebral attention networks
Kurth, Sophie ULg; Majerus, Steve ULg; Bastin, Christine ULg et al

in Neurobiology of Aging (2016), 44

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an ... [more ▼]

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an under-investigated question, age effects on DAN and VAN activity and their functional balance were explored during performance of a STM task. Older and young groups showed similar behavioral patterns of results. At the cerebral level, DAN activation increased as a function of increasing STM load in both groups, suggesting preserved activity in DAN during healthy aging. Age-related over-recruitment in regions of the DAN in the higher task load raised the question of compensation attempt versus less efficient use of neural resources in older adults. Lesser decrease of VAN activation with increasing load and decreased stimulus-driven activation in the VAN, especially in the higher load, in older participants suggested age-related reduced response in the VAN. However, functional connectivity measures showed that VAN was still functionally connected to the DAN in older participants. [less ▲]

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See detailBridging familiarity and novelty detection: a matter of timing?
Delhaye, Emma ULg; Barbeau, Emmanuel; Moulin, Christopher et al

Conference (2016, July 21)

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See detailRecollection versus familiarity in normal aging and in mild cognitive impairment: Impact of test format.
Simon, Jessica ULg; Gilsoul, Jessica ULg; SALMON, Eric ULg et al

Poster (2016, July 18)

The aim of this study was to investigate the impact of test format on recollection and familiarity in normal aging and in MCI. Seventy young participants, 65 younger-old, 53 older-old, and 13 MCIs were ... [more ▼]

The aim of this study was to investigate the impact of test format on recollection and familiarity in normal aging and in MCI. Seventy young participants, 65 younger-old, 53 older-old, and 13 MCIs were presented with forced-choice and yes/no visual recognition memory tasks with the Remember/Know/Guess paradigm. The young people had better recognition performance than younger-old, who performed better than older-old and MCIs. Recollection and familiarity declined progressively in healthy aging. In MCI, recollection was more affected than familiarity, but patients demonstrated a more liberal use of familiarity. Finally, test format did not influence strongly the results. Young people used recollection more often in the forced-choice task compared to the yes/no task. [less ▲]

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See detailDisrupted interaction between self and memory in patients with Alzheimer’s disease
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

Conference (2016, July)

In humans, self and memory processes interact as evidenced by the self reference (SRE) and self reference recollection effects (SRRE). However, in patients with Alzheimer’s disease (AD), this relationship ... [more ▼]

In humans, self and memory processes interact as evidenced by the self reference (SRE) and self reference recollection effects (SRRE). However, in patients with Alzheimer’s disease (AD), this relationship can be disrupted. This was evidenced by impaired SRE and SRRE in AD for recognition of adjectives previously judged for self-relevance, as well as recall of names of people previously linked to the self. For both materials, a qualitative impairment of the recollective experience for the self-related items was also observed in AD. A neuroimaging approach suggested that reduced SRE is related to decreased grey matter volume in the lateral prefrontal cortex (lPFC). Thus, retrieval of recent self-related memories is impaired in relation to altered high-order processes in lPFC in AD. [less ▲]

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See detailSubstrats neuronaux de l'encodage non réussi dans le vieillissement
François, Sarah ULg; Angel, Lucie; Salmon, Eric ULg et al

Conference (2016, May 27)

Objectifs En utilisant l'IRM fonctionnelle, nous nous sommes intéressés à l'effet de l'âge sur les substrats neuronaux de l'encodage non réussi – l'activation à l'encodage pour les items oubliés par la ... [more ▼]

Objectifs En utilisant l'IRM fonctionnelle, nous nous sommes intéressés à l'effet de l'âge sur les substrats neuronaux de l'encodage non réussi – l'activation à l'encodage pour les items oubliés par la suite. Méthodologie Dans un scanner IRM, nous avons soumis des volontaires (20 jeunes et 19 âgés) à une tâche de mémoire épisodique avec consignes d'encodage incident. Durant celle-ci, des dessins d'objets en noir et blanc leur étaient présentés. Il leur était demandé d'effectuer un jugement de taille sur ces objets. Ensuite, toujours dans le scanner, les objets de la phase d'encodage ainsi que de nouveaux objets leurs étaient présentés afin d'évaluer leur reconnaissance de ceux-ci. Pour ce faire, les volontaires effectuaient un jugement de Recollection/Familiarité/Nouveauté. Résultats Les résultats comportementaux montrent une recollection altérée mais une familiarité préservée chez nos volontaires âgés. L'analyse des résultats IRM a été effectuée selon un design évènementiel (SPM8), dans lequel nous avons comparé les aires cérébrales activées à l'encodage pour les items qui n'ont pas été reconnus ultérieurement et pour ceux qui ont donné lieu à un jugement de recollection (p<.001 non-corrigé). Dans les deux groupes, un pattern d'activation correspondant au réseau du mode par défaut (RMD). Chez les volontaires âgés, les résultats ont également mis en évidence une activation supplémentaire du réseau attentionnel fronto-pariétal. Ensuite, le contraste entre les activations pour les items qui n'ont pas été reconnus ultérieurement et ceux qui ont donné lieu à un jugement de familiarité a aussi mis en évidence des régions du RMD, mais dans une moindre mesure. En effet, les activités communes aux deux groupes d'âge n'ont montré qu'une activation du précuneus. Discussion Comparé à la recollection, l'oubli d'informations semble associé, à l'encodage, à un recrutement accru du RMD qui pourrait refléter une incapacité à mettre en place des processus d'encodage efficaces, à la fois chez les jeunes adultes et les adultes plus âgés. De plus, l'activation supplémentaire du réseau fronto-pariétal chez ces derniers pourrait indiquer un fonctionnement moins différencié des réseaux cérébraux associés à l'encodage en mémoire. Lorsque l'on compare l'oubli d'informations à la familiarité, l'activation moindre du RMD pourrait suggérer qu'un certain niveau d'activation du RMD (et donc la présence de pensées étrangères à la tâche) n'empêche pas forcément toute reconnaissance sur base d'un sentiment de familiarité. [less ▲]

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See detailRecollection and Familiarity in Normal Aging
Simon, Jessica ULg; Gilsoul, Jessica ULg; Bastin, Christine ULg

Conference (2016, May 11)

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See detailEpisodic memory and aging: The effect of perceptual processing fluency on recognition memory processes
Bastin, Christine ULg; Willems, Sylvie ULg

Poster (2016, April 03)

Normal aging is characterized by decreased recollection, but better preserved familiarity. Memory tasks that facilitate the use of familiarity should allow attenuating age-related differences in memory ... [more ▼]

Normal aging is characterized by decreased recollection, but better preserved familiarity. Memory tasks that facilitate the use of familiarity should allow attenuating age-related differences in memory. The study tested two hypotheses: (1) can the reliance on familiarity during recognition memory be promoted by increasing the difference in perceptual processing fluency between old and new items; (2) can this manipulation reduce age-related difficulties in episodic memory? Twenty-four young and 24 older adults performed two verbal recognition memory tasks. In the No-Overlap task, target words and new words did not share any letter. Prior exposition to the target words thus induced increased processing fluency of the words and letters, so that fluency difference was a salient and reliable cue to discriminate between old and new words. In the Overlap task, target and new words had letters in common, so fluency cues were less useful. Recollection and familiarity was assessed with the Remember/Know/Guess paradigm. The results showed an age effect on recollection but intact familiarity. Moreover, (1) memory performance was better in the No Overlap than the Overlap task, with a greater hit rate and a smaller false alarm rate associated with familiarity. And, (2) age-related differences in recognition accuracy (hits – false alarms) were significantly attenuated in the No Overlap task compared to the Overlap task. These findings suggest that minimizing the perceptual similarity between targets and distractors, and thus increasing processing fluency differences, allowed to reduce the effect of age on recognition memory performance by facilitating the use of familiarity. [less ▲]

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See detailRecollection versus familiarity in normal aging and in mild cognitive impairment: Impact of test format
Gilsoul, Jessica ULg; Simon, Jessica ULg; SALMON, Eric ULg et al

Poster (2016, March 18)

Objectives. Memory retrieval typically involves a combination of recollection and familiarity. However, test format can promote one or the other process (Norman & O’Reilly, 2003). The aim of this study ... [more ▼]

Objectives. Memory retrieval typically involves a combination of recollection and familiarity. However, test format can promote one or the other process (Norman & O’Reilly, 2003). The aim of this study was to investigate the impact of test format on recollection and familiarity in normal aging and in mild cognitive impairment (MCI). Methods. Seventy young participants (18-30 years), 65 “younger-old” (55- 69 years), 53 “older-old” (70-85 years), and 13 MCIs (55-82 years) were enrolled. In the “forced-choice” task, they had to recognize which picture, among three, was presented during the encoding stage. In the “yes/no” task, they had to judge whether each item, successively presented, was previously seen or not. In each task, they had to give a “Remember/Know/Guess” judgment. Results. Group × Format repeated measures ANOVAs revealed that young people had better recognition performance (d’) than “younger-old”, which were better than “older-old” and MCIs. Moreover, young people used familiarity more accurately than both groups of old participants and MCIs, with MCIs being equivalent to “younger-old” and “older-old”. However, MCIs displayed a high rate of familiarity-based false alarms. The resort to recollection decreased with age and in MCIs. Finally, Group × Format interaction revealed that young people (but not the other groups) could use recollection more often in the “forcedchoice” task compared to the “yes/no” task. Conclusions. Recollection and familiarity decline progressively in healthy aging. In MCI, recollection is more affected than familiarity, but patients demonstrated a more liberal use of familiarity. Finally, test format did not influence strongly the results. [less ▲]

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