References of "Bastin, Christine"
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See detailBridging novelty and familiarity-based recognition memory: a matter of timing
Delhaye, Emma ULiege; Bastin, Christine ULiege; Moulin, Christopher et al

in Visual Cognition (in press)

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See detailSelf in Dementia
Antoine, Nicolas ULiege; Genon, Sarah ULiege; Bastin, Christine ULiege et al

in Mishara; Corlett, P.; Fletcher, P. (Eds.) et al Phenomenological Neuropsychiatry, How Patient Experience Bridges Clinic with Clinical Neuroscience (in press)

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See detailDissociation entre recollection objective et subjective dans le vieillissement normal : une approche par analyses multiniveaux
Folville, Adrien ULiege; D'Argembeau, Arnaud ULiege; Bastin, Christine ULiege

Poster (2017, December 01)

Bien que le vieillissement normal soit associé à un déclin en recollection lorsque ce processus est mesuré de façon objective (mémoire de source ou rappel libre), l’expérience subjective de recollection ... [more ▼]

Bien que le vieillissement normal soit associé à un déclin en recollection lorsque ce processus est mesuré de façon objective (mémoire de source ou rappel libre), l’expérience subjective de recollection (vivacité du souvenir) demeure stable au cours du vieillissement, suggérant l’existence d’une dissociation entre ces deux processus (Mcdonough et al. 2014). A ce jour, les recherches ont toujours comparé ces deux aspects de la recollection séparément en mesurant les scores moyens de chaque participant, si bien que la relation entre mesures objective et subjective de recollection avec une approche essai-par-essai reste inconnue. Afin d’examiner cette question, nous avons recruté 34 participants jeunes et 34 participants âgés. Ils ont pris part à une tâche de recollection indicée au cours de laquelle ils mémorisaient des images complexes associées des titres descriptifs, chaque image étant présentée à gauche ou à droite de l’écran et avant ou après une pause. A la récupération, pour chaque essai, les participants devaient répondre à une question de mémoire de source spatiale ou temporelle et émettre un jugement de vivacité concernant leur souvenir de l’image associé au titre. Ensuite, les participants étaient invités à rappeler oralement autant d’éléments que possible concernant l’image. Des analyses multiniveaux ont été utilisées pour évaluer la relation entre les mesures de recollection subjective (vivacité) et objective (rappel libre) à travers les essais dans les deux groupes. Les résultats ont mis en évidence une différence significative entre les groupes en mémoire de source. Les participants âgés ont émis des jugements de vivacité plus élevés que les participants jeunes bien que leurs rappels libres soient moins détaillés, mettant ainsi en évidence une dissociation entre ces mesures. Les analyses multiniveaux ont révélé que la quantité de détail rappelé était un prédicteur significatif du jugement de vivacité dans les deux groupes, bien que cette relation soit plus importante chez les sujets jeunes par rapport aux âgés. Nos mesures de recollection objective suggèrent que le vieillissement normal diminue notre capacité à récupérer des informations contextuelles et des détails visuels associés à des souvenirs complexes. Les analyses multiniveaux suggèrent que les participants âgés ajusteraient moins bien leurs jugements subjectifs de vivacité vis-à-vis de la quantité d’information qu’ils récupèrent en mémoire comparé aux jeunes. Nous émettons l’hypothèse que des changements métacognitifs liés à l’âge ou qu’une utilisation d’informations différentes pour émettre un jugement de vivacité puisse expliquer cette faible correspondance entre recollection objective et subjective dans le vieillissement normal. [less ▲]

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See detailMeasuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.
Bahri, Mohamed Ali ULiege; Plenevaux, Alain ULiege; Aerts, Joël ULiege et al

in Alzheimer’s & Dementia: Translational Research & Clinical Interventions (2017), 4(4), 481-486

Introduction: Brain distribution of synaptic vesicle protein 2Awas measured with fluorine-18 UCBH ([18F]UCB-H) and positron emission tomography (PET). Methods: Images of synaptic density were acquired in ... [more ▼]

Introduction: Brain distribution of synaptic vesicle protein 2Awas measured with fluorine-18 UCBH ([18F]UCB-H) and positron emission tomography (PET). Methods: Images of synaptic density were acquired in healthy volunteers (two young participants and two seniors). Input function was measured by arterial blood sampling (arterial input function) and derived from PET images using carotid activity (image-derived input function). Logan graphical analysis was used to estimate regional synaptic vesicle protein 2A distribution volume. Results: [18F]UCB-H uptake was ubiquitous in cortical and subcortical gray matter. Arterial input function and image-derived input function provided regional distribution volume with a high linear relationship. Discussion: The cerebral distribution of [18F]UCB-H is similar to that recently observed with carbon-11 UCB-J ([11C]UCB-J). An accurate [18F]UCB-H quantification can be performed without invasive arterial blood sampling when no suitable reference region is available, using dynamic PET carotid activity. Brain synaptic density can be studied in vivo in normal and pathological aging. [less ▲]

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See detailExploration des processus de recollection et de familiarité chez des patients présentant une plainte mnésique : Une étude longitudinale
Simon, Jessica ULiege; Collette, Fabienne ULiege; Salmon, Eric ULiege et al

Poster (2017, June 01)

Les données actuelles suggèrent une altération précoce de la recollection dans les premiers stades de la maladie d’Alzheimer. Par contre, aucun consensus n’a pu être dégagé concernant l’intégrité de la ... [more ▼]

Les données actuelles suggèrent une altération précoce de la recollection dans les premiers stades de la maladie d’Alzheimer. Par contre, aucun consensus n’a pu être dégagé concernant l’intégrité de la familiarité. En effet, certaines études suggèrent une altération précoce de ce processus, alors que d’autres montrent une préservation de celle-ci. Dans ce cadre, nous avons exploré l'impact du type de format de reconnaissance et du matériel sur la recollection et la familiarité chez des patients qui se plaignent de leur mémoire. Nous avons recruté 23 participants âgés contrôles, 9 patients présentant un trouble subjectif de la mémoire (SCI) et 23 patients présentant un trouble cognitif léger (TCL). Les participants ont réalisé une tâche de reconnaissance à choix forcé à deux alternatives et une tâche de reconnaissance Oui-Non incluant des images et des mots. Ces tâches étaient suivies d’une courte évaluation neuropsychologique. Quinze participants âgés contrôles et 23 patients ont participé au suivi, incluant une évaluation neuropsychologique, dans un délai moyen de 21 mois. Nos résultats montrent qu’à l’inclusion, les patients avec TCL avaient des performances moindres en reconnaissance que les deux autres groupes, qui ne différaient pas. De même, ces patients utilisaient moins efficacement la recollection et la familiarité par rapport aux contrôles et aux SCI, qui présentaient des performances similaires. Il n’y avait aucune interaction entre le groupe et le type de format ou le matériel. Lors du suivi, cinq patients avec TCL ont retrouvé un niveau d’efficience cognitive dans la norme et ont été considérés comme des SCI car les plaintes mnésiques étaient toujours présentes. Sur la base de l'adaptation française du test de rappel libre et indicé (RLRI-16), nous avons calculé une pente de déclin mnésique pour chacun de nos patients. Nous avons observé que les indices de recollection et de familiarité étaient expliqués par les pentes de déclin calculées sur le nombre total d’items rappelés librement. Ainsi, nous avons observé un déclin de la recollection et la familiarité dans le groupe de TCL mais pas dans celui des SCI, bien que les deux groupes se plaignent de leur mémoire. En outre, l'efficacité de la familiarité pourrait prédire un déclin cognitif futur. [less ▲]

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See detailTree Ensemble Methods and Parcelling to Identify Brain Areas Related to Alzheimer’s Disease
Wehenkel, Marie ULiege; Bastin, Christine ULiege; Phillips, Christophe ULiege et al

in 2017 International Workshop on Pattern Recognition in Neuroimaging (PRNI), proceedings (2017, June)

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULiege; Blanpain, Manon ULiege; Van Egroo, Maxime ULiege et al

Poster (2017, May 31)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Method. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region. Discussion. In a late middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects. [less ▲]

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULiege; Blanpain, Manon ULiege; Van Egroo, Maxime ULiege et al

Poster (2017, May 19)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Method. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region. Discussion. In a late middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects. [less ▲]

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See detailMémoire et vieillissement: Les mécanismes qui ne sont pas affectés par l'âge
Bastin, Christine ULiege

Conference (2017, May 19)

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See detailRecollection versus familiarité dans le vieillissement normal et pathologique : Impact du format du test
Simon, Jessica ULiege; Gilsoul, Jessica ULiege; SALMON, Eric ULiege et al

Poster (2017, May 19)

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to ... [more ▼]

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to these populations. One condition influencing the relative contribution of recollection and familiarity during recognition is the format of the test. The aim of this study was to investigate the impact of test format on recollection and familiarity in normal aging and in MCI in two tasks where the level of performance is equalized. Seventy young participants, 70 younger-old (55-69 years old), 69 older-old (70-85 years old), and 13 MCIs were presented with forced-choice and yes/no visual recognition memory tasks with the Remember/Know/ Guess paradigm. Young participants had better recognition memory performance than younger-old, who performed better than older-old and MCIs. Recollection and familiarity declined progressively in healthy aging. In MCI, recollection was more affected than familiarity, but patients demonstrated a more liberal use of familiarity. Finally, test format did not influence strongly the results. Young people used recollection more often in the forced-choice task compared to the yes/no task. [less ▲]

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See detailExploration des processus de recollection et de familiarité chez des patients présentant une plainte mnésique : une étude longitudinale
Simon, Jessica ULiege; Collette, Fabienne ULiege; SALMON, Eric ULiege et al

Poster (2017, May 19)

Recollection refers to recall of details about past events, and familiarity is a feeling of oldness. In this study, we tested how recollection and familiarity are affected in patients with memory ... [more ▼]

Recollection refers to recall of details about past events, and familiarity is a feeling of oldness. In this study, we tested how recollection and familiarity are affected in patients with memory complaints compared to normal aging. We recruited 23 healthy older participants, 9 patients with subjective memory impairment (SCI) and 23 patients with mild cognitive impairment (MCI). Participants performed one 2-alternative forced-choice and one Yes-No recognition memory task including pictures and words, followed by a short neuropsychological evaluation. Fifteen healthy participants and 23 patients (9 SCI and 14 MCI) took part in a neuropsychological follow-up after a mean delay of 21 months. At inclusion, MCI patients had poorer performance in recognition than the other groups, which did not differ. MCI patients had worse performance regarding familiarity and recollection indexes compared to healthy controls and SCI, who exhibit similar performance. There was no interaction between groups and format or material. During the follow-up evaluation, five MCI returned to a normal level of efficiency and were considered as SCI. Based on the French adaptation of the free and cued selective reminding test (RLRI-16), we calculated cognitive decline curves in our patients. We observed that recollection and familiarity indexes were explained by the decline curves calculated on the number of freely recalled items. So, recollection and familiarity were used less efficiently in MCI than SCI although both groups complained about their memory. [less ▲]

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See detailRecollection versus familiarity in normal aging and in mild cognitive impairment: Impact of test format
Simon, Jessica ULiege; Gilsoul, Jessica ULiege; SALMON, Eric ULiege et al

Poster (2017, March 24)

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to ... [more ▼]

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to these populations. One condition influencing the relative contribution of recollection and familiarity during recognition is the format of the test. The aim of this study was to investigate the impact of test format on recollection and familiarity in normal aging and in MCI in two tasks where the level of performance is equalized. Seventy young participants, 70 younger-old (55-69 years old), 69 older-old (70-85 years old), and 13 MCIs were presented with forced-choice and yes/no visual recognition memory tasks with the Remember/Know/ Guess paradigm. Young participants had better recognition memory performance than younger-old, who performed better than older-old and MCIs. Recollection and familiarity declined progressively in healthy aging. In MCI, recollection was more affected than familiarity, but patients demonstrated a more liberal use of familiarity. Finally, test format did not influence strongly the results. Young people used recollection more often in the forced-choice task compared to the yes/no task. [less ▲]

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See detailImpact of the number of alternatives during a forced-choice recognition task on recollection and familiarity in normal aging
Simon, Jessica ULiege; Gilsoul, Jessica ULiege; Bastin, Christine ULiege

Poster (2017, March 23)

Forced-choice recognition tasks are often used to evaluate recognition memory. However, no study have specifically investigate the impact of the number of alternatives on memory performance. Here, we ... [more ▼]

Forced-choice recognition tasks are often used to evaluate recognition memory. However, no study have specifically investigate the impact of the number of alternatives on memory performance. Here, we wanted to determine, on the one hand, if the number of alternatives - two or three - and on the other hand if the degree of similarity between targets and foils have an impact on recognition strategies. Moreover, we investigated how aging interacted with these variables. We recruited 20 young and 20 older participants. During the reconnaissance task, they had to choose, among two or three photographs of faces, the one that was presented previously. Some couples of targets and foils were more similar than others (sharing 60% of common characteristics versus 40%). For each selected item, the participants had to explain what guided their choice via verbal reports. We observed similar performance between the groups for the two-alternative recognition memory task, while young participants had better performance than the older participants in the three-alternative task. Young participants used more often recollection when the similarity between targets and foils was higher, unlike older participants whose rate of recollection was not influenced by target-foil similarity. Both groups used more often familiarity in the two-alternative task, but older participants demonstrated a more liberal bias. Finally, our participants used more often elimination strategies when the similarity is low or when they had to select one item out of three. [less ▲]

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See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULiege; Simon, Jessica ULiege; Bahri, Mohamed Ali ULiege et al

Poster (2017, March 23)

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULiege; Blanpain, Manon ULiege; Van Egroo, Maxime ULiege et al

Poster (2017, March 23)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Methods. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35, while there were no significant correlations in the right hemisphere. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region, what is more contradictory according to the current literature. No significant link was found between BPS and the volume of hippocampal subfields in the left hemisphere. Conclusion. In a middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects [less ▲]

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See detailNeural correlates of subsequent recollection and familiarity in ageing
François, Sarah ULiege; Angel, Lucie; Salmon, Eric ULiege et al

Poster (2017, March)

It is now commonly accepted that, in ageing, recollection processes are impaired and familiarity seems to be relatively preserved. In this study, we were interested in the differences between younger and ... [more ▼]

It is now commonly accepted that, in ageing, recollection processes are impaired and familiarity seems to be relatively preserved. In this study, we were interested in the differences between younger and older participants regarding cerebral activity during encoding depending on whether the item later elicited recollection or familiarity. Twenty young volunteers and 19 older volunteers were presented visual stimuli depicting objects. After a first fMRI session in which the items were encoded, they underwent a recognition memory task in which they judged whether items were Remembered, Familiar or New. Data were analysed using SPM8, with an event-related design comparing modifications in cerebral activity between the two subjects groups during encoding (1) for the items leading to recollection compared to those leading to familiarity, and (2) for the items associated with familiarity compared to those which were not recognized. Results showed that older adults displayed a heightened activity in regions of the default-mode network for subsequent recollection. As it does not appear to be deleterious, it could stem from a more frequent use of self-referential appraisal as an encoding strategy in older adults. Furthermore, they show supplementary contralateral activations in frontal and temporal regions, which could be indicative of dedifferentiation or attempted compensation. To conclude, it appears that despite relying less on elaborative encoding, older adults seem to be able to perform recollection using qualitatively different strategies than young adults. [less ▲]

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See detailAging and Recollection: a context story
Folville, Adrien ULiege; Bastin, Christine ULiege; Willems, Sylvie ULiege

Poster (2017, March)

Although aging is related to decline in recollection as measured by so-called objective measures, older adults’ subjective experience of recollection remains sometimes stable. Such dissociation could ... [more ▼]

Although aging is related to decline in recollection as measured by so-called objective measures, older adults’ subjective experience of recollection remains sometimes stable. Such dissociation could suggest that younger and older adults use details with different diagnosticity to make subjective recollection judgments. However, the type of details that are reported as bases for recollective experiences by younger adults can also vary as a function of context. Here, we directly investigated age-related changes in recollection and familiarity in different memorability context. Participants studied one set of words in a medium level of processing (LOP) task, and another set of words with either a shallow or deep LOP task (i.e., low vs. high memorability context, respectively). At test, participants discriminated between old and new words and provided information about the basis of their recollective experiences. In both age groups, medium items received more recollection judgments in low (vs. high) memorability context. These recollections seem to be associated with internal information (thought, image, emotion). In contrast, external details (list source, appearance, list position) more often accompanied recollection of medium items in high (vs. low) memorability context. We discuss this effect in terms of Gruppuso et al.’s (1997) functional account. Like younger adults, what older adults deem to be an experience of remembering arises from the functional utility of the recollected information for accomplishing the task. In the low (vs. high) memorability context, the information recollected for medium items more easily met the functional definition of remembering established by participants during the test. [less ▲]

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