References of "BOVY, Christophe"
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See detailIncreased iron absorption during autologous blood donation supported by recombinant human erythropoietin therapy.
Bovy, Christophe ULg; Baudoux, Etienne ULg; Salmon, Jean ULg et al

in Transfusion (2006), 46(9), 1616-23

BACKGROUND: Recombinant human erythropoietin (rHuEPO) therapy improves the success of autologous blood (AB) donation programs before elective surgery. The aim of this study was to evaluate iron absorption ... [more ▼]

BACKGROUND: Recombinant human erythropoietin (rHuEPO) therapy improves the success of autologous blood (AB) donation programs before elective surgery. The aim of this study was to evaluate iron absorption during an AB donation program with or without rHuEPO. STUDY DESIGN AND METHODS: Thirty-two patients were randomly assigned among placebo (Group 1) or 300 (Group 2) or 600 UI per kg rHuEPO (Group 3) on the first, second, and third donation visits. All patients also received daily oral iron (200 mg Fe(+)). RESULTS: The number of units collected in Group 3 was higher than in Group 1 (4.6 +/- 0.5 vs. 3.6 +/- 0.8 units; p < 0.01). Red blood cell (RBC) production increased in a rHuEPO dose-dependent manner. With rHuEPO, the RBC volume collected per unit presented a lower decrease with number of donated units than with placebo and was similar to that of homologous blood units. Storage iron did not influence the number of units collected, whereas circulating mobilizable iron was the limiting factor. Oral iron absorption increased in a rHuEPO dose-dependent manner (12-fold with 600 UI/kg rHuEPO) and was proportional to erythropoietic activity. CONCLUSION: rHuEPO does not only improve the number of AB units collected but also their quality. Storage iron cannot meet marrow iron requirements, but rHuEPO strongly increased oral iron absorption in a dose-dependent fashion through stimulation of erythropoietic activity. [less ▲]

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See detailComment j'explore ... l'hypertension artérielle par excès de minéralocorticoides
Bovy, Christophe ULg; Delanaye, Pierre ULg; Radermecker, Régis ULg et al

in Revue Médicale de Liège (2005), 60(4), 255-63

Primary aldosteronism is a rare cause of hypertension. However, its incidence seems to be underestimated. It is important to identify this syndrom since the disease is potentially curable. In the present ... [more ▼]

Primary aldosteronism is a rare cause of hypertension. However, its incidence seems to be underestimated. It is important to identify this syndrom since the disease is potentially curable. In the present paper, we depict different forms of primary aldosteronism as well as the diagnostic procedures. When the diagnosis is suspected (hypertension associated to spontaneous or diuretic-induced hypokaliemia), the more efficient screening test is the determination of the aldosteron/renin ratio. Saline infusion or posture tests can thereafter confirm the diagnosis. Differential diagnosis between bilateral and unilateral forms of primary aldosteronism can be made by CT-scanner and the response of aldosterone to the posture test. Such a complex assessment leads to the identification of patients who can be surgically treated. This treatment consists in a unilateral adrenalectomy which can be realised by laparoscopy. [less ▲]

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See detailPrimary amyloidosis (AL) as a cause of nephrotic syndrome.
Bataille, Yoann ULg; Bovy, Christophe ULg; Lancellotti, Patrizio ULg et al

in Acta Clinica Belgica (2005), 60(2), 94-7

AL amyloidosis is a rare systemic disease resulting from tissue accumulation of amyloid fibrils derived from monoclonal immunoglobulin light chains. It can disrupt the tissue architecture and consequently ... [more ▼]

AL amyloidosis is a rare systemic disease resulting from tissue accumulation of amyloid fibrils derived from monoclonal immunoglobulin light chains. It can disrupt the tissue architecture and consequently cause organ dysfunction. The prognosis is poor with a median survival of 13 months in untreated patients. By illustrating the case of a patient whose AL amyloidosis was detected after presenting a nephrotic syndrome, the characteristics of the disease are reviewed as well as diagnostic criteria and current available therapeutics. [less ▲]

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See detailMature erythrocyte indices: new markers of iron availability.
Bovy, Christophe ULg; Gothot, André ULg; Krzesinski, Jean-Marie ULg et al

in Haematologica (2005), 90(4), 549-51

This study was aimed at evaluating mature erythrocyte indices as new markers of iron status. Contrarily to those in the whole red blood cell (RBC) population, mature erythrocyte parameters are valid ... [more ▼]

This study was aimed at evaluating mature erythrocyte indices as new markers of iron status. Contrarily to those in the whole red blood cell (RBC) population, mature erythrocyte parameters are valid markers of iron status that remain independent of erythropoietic activity. When reticulocytosis is low, these parameters are similar to whole RBC parameters. [less ▲]

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See detailL'image du mois. Amylose cardiaque
Bataille, Yoann ULg; Bovy, Christophe ULg; Pierard, Luc ULg et al

in Revue Médicale de Liège (2004), 59(10), 549

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See detailBack pain and renal failure
Delanaye, Pierre ULg; Bovy, Christophe ULg; de Leval, Laurence ULg et al

in Lancet (2004), 364(9449), 1992

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See detailImpact of erythropoietic activity on red cell parameters in chronic renal failure patients.
Bovy, Christophe ULg; Krzesinski, Jean-Marie ULg; Gothot, André ULg et al

in Haematologica (2004), 89(6), 748-9

We measured red cell parameters during recombinant human erythropoietin (rHuEPO) therapy associated with appropriate iron supplementation in chronic hemodialysis patients. Increased erythropoietic ... [more ▼]

We measured red cell parameters during recombinant human erythropoietin (rHuEPO) therapy associated with appropriate iron supplementation in chronic hemodialysis patients. Increased erythropoietic activity led to a bias in red cell parameter determination. The percentage of hypochromic red blood cells, usually used as the most effective predictor of response to iron supplementation, increased following the appearance of a younger red cell population since the same Hb content in these younger, larger cells gives a lower Hb concentration. [less ▲]

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See detailHypochromic mature erythrocytes: a specific marker of iron deficiency
Bovy, Christophe ULg; Beguin, Yves ULg; Gothot, André ULg et al

in Acta Clinica Belgica (2003), 58-3(4), 325

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See detailFollow-up of iron microalbuminuria in hypertensive patients: a belgian promise survey
Bovy, Christophe ULg; Beguin, Yves ULg; Gothot, André ULg et al

in Acta Clinica Belgica (2003), 58-3(4), 328

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See detailComparison of plasma cardiac troponins T and I in chronically hemodialyzed patients in relation to cardiac status and age
Chapelle, Jean-Paul ULg; Dubois, Bernard ULg; Bovy, Christophe ULg et al

in Clinical Chemistry & Laboratory Medicine (2002), 40(3), 240-245

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See detailIron monitoring under vitamin C therapy in hemodialysed patients treated with erythropoietin
Bovy, Christophe ULg; Dubois, Bernard ULg; Weekers, Laurent ULg et al

in Nephrology Dialysis Transplantation (2000), 15(9), 156

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See detailFactors determining the percentage of hypochromic red blood cells in hemodialysis patients.
Bovy, Christophe ULg; Tsobo, C.; Crapanzano, L. et al

in Kidney International (1999), 56(3), 1113-9

Factors determining the percentage of hypochromic red blood cells determines iron status in hemodialysis patients. BACKGROUND: Determination of the percentage of hypochromic red blood cells (RBC; %HYPO ... [more ▼]

Factors determining the percentage of hypochromic red blood cells determines iron status in hemodialysis patients. BACKGROUND: Determination of the percentage of hypochromic red blood cells (RBC; %HYPO) has been advocated as a sensitive index of functional iron deficiency during erythropoietin (EPO) therapy in hemodialyzed patients. METHODS: The significance of %HYPO in chronic renal failure was evaluated in 64 chronically hemodialyzed patients. The linear correlation was determined between %HYPO and 13 variables, including age, sex, weight, C-reactive protein (CRP), ferritin, transferrin (Tf), Tf saturation, soluble Tf receptor (sTfR), serum iron (SI), urea, parathormone, dialysis dose (Kt/V), dose of EPO administered (EPO), and absolute reticulocyte count. Multiple regression analyses were then performed to select the parameters that jointly provide the best prediction of %HYPO. RESULTS: Univariate analysis showed significant correlations between %HYPO and iron parameters (sTfR, Tf saturation, SI, and ferritin, in decreasing order), EPO, reticulocyte count, and CRP. Multivariate analysis yielded an equation showing that the variation of %HYPO is essentially associated with the combined changes in sTfR, CRP, and EPO dosage. CONCLUSIONS: %HYPO is a meaningful and inexpensive parameter that reflects the integrated effects of iron stores, inflammation, and erythropoietic stimulation on iron availability in hemodialyzed patients. Among iron exchange parameters, sTfR is the best predictor of %HYPO, followed by Tf saturation, SI, and ferritin. [less ▲]

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See detailLipids, risk factor in hemodialysed patients?
BOVY, Christophe ULg; Saint-Remy, Annie ULg; Juchmes, A. et al

in Nephrology Dialysis Transplantation (1998), 13

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See detailMode of administration of Erythropoetin (rHu-Epo)- Does it matter?
BOVY, Christophe ULg; DUBOIS, Bernard ULg; popovic, Anne et al

in Nephrology Dialysis Transplantation (1995), 10

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