References of "BOVY, Christophe"
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See detailUtilité du mycophénolate mofétil en pathologie rénale en dehors de la transplantation
Parotte, Marie-Christine ULg; Bovy, Christophe ULg; Krzesinski, Jean-Marie ULg

in Revue Médicale Suisse (2007), 3

Glomerular diseases remain frequent causes of end-stage renal failure. Immunosuppressive drugs in association with corticosteroids induce remission of proteinuria and stabilize renal function, as well as ... [more ▼]

Glomerular diseases remain frequent causes of end-stage renal failure. Immunosuppressive drugs in association with corticosteroids induce remission of proteinuria and stabilize renal function, as well as prevent relapses, but are responsible for severe portential side-effects: infections, secondary malignancies, sterility and alopecia, and even nephrotoxicity. Mycophenolate mofetil (MMF), a well-known drug in transplantation, presents interesting characteristics potentially useful in the teatment of glomerulopathies. Moreover, its side-effect profile is safer. The present review of literature suggests that MMF is efficient for the treatment of glomerular disease, even if the results of the different studies remain limited and require further confirmation. [less ▲]

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See detailMature erythrocyte parameters as new markers of functional iron deficiency in haemodialysis: sensitivity and specificity
Bovy, Christophe ULg; Gothot, André ULg; Krzesinski, Jean-Marie ULg et al

in Nephrology Dialysis Transplantation (2007), 11

Background. The percentage of hypochromic red blood cells (RBCs) (%HYPO) has been demonstrated as the best predictor of response to iron loading in haemodialysis patients treated with recombinant human ... [more ▼]

Background. The percentage of hypochromic red blood cells (RBCs) (%HYPO) has been demonstrated as the best predictor of response to iron loading in haemodialysis patients treated with recombinant human erythropoietin (rHuEPO). However, we have previously shown that this parameter is positively influenced by erythropoietic activity since reticulocytes are considered hypochromic by cell counters. New cell counters are able to determine cell volume and haemoglobin (Hb) concentration separately on reticulocytes and mature erythrocytes. The aim of this study was to assess the sensitivity and specificity of mature erythrocyte parameters in detecting functional iron deficiency (FID). Methods. A total of 32 stable chronic haemodialysis patients in the maintenance phase of rHuEPO therapy were included. Classical parameters of iron monitoring and mature erythrocyte parameters were measured after a 4-week iron-free period. Patients were classified as responders (R) or non-responders (NR) to an iron load of 100 mg iron sucrose at each dialysis session for 4 weeks, according to whether their Hb increased by >1 g/dl at the end of iron loading. Results. Twelve patients were identified as responders. Receiver operating characteristic (ROC) curve analysis demonstrated %HYPO and its corresponding parameter on mature erythrocyte, %HYPOm, as the best predictors of FID. The other parameters were ordered as follows: tranferrin saturation (TSAT), ferritin (FRT), mature RBC Hb content (CHm), mean corpuscular Hb concentration (MCHC), percentage of mature erythrocytes with a low CHm (%lowCHm), mean content in Hb (MCH) and reticulocyte Hb content CHr. Comparing the parameters at different cut-offs, the best sensitivity, specificity and efficiency were demonstrated for HYPOm>6%. Conclusion. The best efficiency to predict FID was found for %HYPOm>6%. The predictive value of %HYPO was quite similar. The clinical impact of %HYPOm in iron monitoring should also be tested in the induction phase of rHuEPO treatment because of its independence from erythropoietic activity. [less ▲]

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See detailLa dapsone: une économie de corticoïdes dans le traitement du purpura rhumatoïde? A propos d'un cas observé
Parotte, Marie-Christine ULg; Bovy, Christophe ULg; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2007), 62

Dapsone is a sulfone essentially used to treat leprae. We describe, here, a somewhat rare indication of dapsone: corticoid sparing in the treatment of particular forms of Henoch-Schönlein.

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See detailIncreased iron absorption during autologous blood donation supported by recombinant human erythropoietin therapy.
Bovy, Christophe ULg; Baudoux, Etienne ULg; Salmon, Jean ULg et al

in Transfusion (2006), 46(9), 1616-23

BACKGROUND: Recombinant human erythropoietin (rHuEPO) therapy improves the success of autologous blood (AB) donation programs before elective surgery. The aim of this study was to evaluate iron absorption ... [more ▼]

BACKGROUND: Recombinant human erythropoietin (rHuEPO) therapy improves the success of autologous blood (AB) donation programs before elective surgery. The aim of this study was to evaluate iron absorption during an AB donation program with or without rHuEPO. STUDY DESIGN AND METHODS: Thirty-two patients were randomly assigned among placebo (Group 1) or 300 (Group 2) or 600 UI per kg rHuEPO (Group 3) on the first, second, and third donation visits. All patients also received daily oral iron (200 mg Fe(+)). RESULTS: The number of units collected in Group 3 was higher than in Group 1 (4.6 +/- 0.5 vs. 3.6 +/- 0.8 units; p < 0.01). Red blood cell (RBC) production increased in a rHuEPO dose-dependent manner. With rHuEPO, the RBC volume collected per unit presented a lower decrease with number of donated units than with placebo and was similar to that of homologous blood units. Storage iron did not influence the number of units collected, whereas circulating mobilizable iron was the limiting factor. Oral iron absorption increased in a rHuEPO dose-dependent manner (12-fold with 600 UI/kg rHuEPO) and was proportional to erythropoietic activity. CONCLUSION: rHuEPO does not only improve the number of AB units collected but also their quality. Storage iron cannot meet marrow iron requirements, but rHuEPO strongly increased oral iron absorption in a dose-dependent fashion through stimulation of erythropoietic activity. [less ▲]

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See detailComment j'explore ... l'hypertension artérielle par excès de minéralocorticoides
Bovy, Christophe ULg; Delanaye, Pierre ULg; Radermecker, Régis ULg et al

in Revue Médicale de Liège (2005), 60(4), 255-63

Primary aldosteronism is a rare cause of hypertension. However, its incidence seems to be underestimated. It is important to identify this syndrom since the disease is potentially curable. In the present ... [more ▼]

Primary aldosteronism is a rare cause of hypertension. However, its incidence seems to be underestimated. It is important to identify this syndrom since the disease is potentially curable. In the present paper, we depict different forms of primary aldosteronism as well as the diagnostic procedures. When the diagnosis is suspected (hypertension associated to spontaneous or diuretic-induced hypokaliemia), the more efficient screening test is the determination of the aldosteron/renin ratio. Saline infusion or posture tests can thereafter confirm the diagnosis. Differential diagnosis between bilateral and unilateral forms of primary aldosteronism can be made by CT-scanner and the response of aldosterone to the posture test. Such a complex assessment leads to the identification of patients who can be surgically treated. This treatment consists in a unilateral adrenalectomy which can be realised by laparoscopy. [less ▲]

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See detailPrimary amyloidosis (AL) as a cause of nephrotic syndrome.
Bataille, Yoann ULg; Bovy, Christophe ULg; Lancellotti, Patrizio ULg et al

in Acta Clinica Belgica (2005), 60(2), 94-7

AL amyloidosis is a rare systemic disease resulting from tissue accumulation of amyloid fibrils derived from monoclonal immunoglobulin light chains. It can disrupt the tissue architecture and consequently ... [more ▼]

AL amyloidosis is a rare systemic disease resulting from tissue accumulation of amyloid fibrils derived from monoclonal immunoglobulin light chains. It can disrupt the tissue architecture and consequently cause organ dysfunction. The prognosis is poor with a median survival of 13 months in untreated patients. By illustrating the case of a patient whose AL amyloidosis was detected after presenting a nephrotic syndrome, the characteristics of the disease are reviewed as well as diagnostic criteria and current available therapeutics. [less ▲]

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See detailMature erythrocyte indices: new markers of iron availability.
Bovy, Christophe ULg; Gothot, André ULg; Krzesinski, Jean-Marie ULg et al

in Haematologica (2005), 90(4), 549-51

This study was aimed at evaluating mature erythrocyte indices as new markers of iron status. Contrarily to those in the whole red blood cell (RBC) population, mature erythrocyte parameters are valid ... [more ▼]

This study was aimed at evaluating mature erythrocyte indices as new markers of iron status. Contrarily to those in the whole red blood cell (RBC) population, mature erythrocyte parameters are valid markers of iron status that remain independent of erythropoietic activity. When reticulocytosis is low, these parameters are similar to whole RBC parameters. [less ▲]

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See detailL'image du mois. Amylose cardiaque
Bataille, Yoann ULg; Bovy, Christophe ULg; Pierard, Luc ULg et al

in Revue Médicale de Liège (2004), 59(10), 549

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See detailBack pain and renal failure
Delanaye, Pierre ULg; Bovy, Christophe ULg; de Leval, Laurence ULg et al

in Lancet (2004), 364(9449), 1992

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See detailImpact of erythropoietic activity on red cell parameters in chronic renal failure patients.
Bovy, Christophe ULg; Krzesinski, Jean-Marie ULg; Gothot, André ULg et al

in Haematologica (2004), 89(6), 748-9

We measured red cell parameters during recombinant human erythropoietin (rHuEPO) therapy associated with appropriate iron supplementation in chronic hemodialysis patients. Increased erythropoietic ... [more ▼]

We measured red cell parameters during recombinant human erythropoietin (rHuEPO) therapy associated with appropriate iron supplementation in chronic hemodialysis patients. Increased erythropoietic activity led to a bias in red cell parameter determination. The percentage of hypochromic red blood cells, usually used as the most effective predictor of response to iron supplementation, increased following the appearance of a younger red cell population since the same Hb content in these younger, larger cells gives a lower Hb concentration. [less ▲]

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See detailHypochromic mature erythrocytes: a specific marker of iron deficiency
Bovy, Christophe ULg; Beguin, Yves ULg; Gothot, André ULg et al

in Acta Clinica Belgica (2003), 58-3(4), 325

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See detailFollow-up of iron microalbuminuria in hypertensive patients: a belgian promise survey
Bovy, Christophe ULg; Beguin, Yves ULg; Gothot, André ULg et al

in Acta Clinica Belgica (2003), 58-3(4), 328

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See detailComparison of plasma cardiac troponins T and I in chronically hemodialyzed patients in relation to cardiac status and age
Chapelle, Jean-Paul ULg; Dubois, Bernard ULg; Bovy, Christophe ULg et al

in Clinical Chemistry & Laboratory Medicine (2002), 40(3), 240-245

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See detailIron monitoring under vitamin C therapy in hemodialysed patients treated with erythropoietin
Bovy, Christophe ULg; Dubois, Bernard ULg; Weekers, Laurent ULg et al

in Nephrology Dialysis Transplantation (2000), 15(9), 156

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See detailFactors determining the percentage of hypochromic red blood cells in hemodialysis patients.
Bovy, Christophe ULg; Tsobo, C.; Crapanzano, L. et al

in Kidney International (1999), 56(3), 1113-9

Factors determining the percentage of hypochromic red blood cells determines iron status in hemodialysis patients. BACKGROUND: Determination of the percentage of hypochromic red blood cells (RBC; %HYPO ... [more ▼]

Factors determining the percentage of hypochromic red blood cells determines iron status in hemodialysis patients. BACKGROUND: Determination of the percentage of hypochromic red blood cells (RBC; %HYPO) has been advocated as a sensitive index of functional iron deficiency during erythropoietin (EPO) therapy in hemodialyzed patients. METHODS: The significance of %HYPO in chronic renal failure was evaluated in 64 chronically hemodialyzed patients. The linear correlation was determined between %HYPO and 13 variables, including age, sex, weight, C-reactive protein (CRP), ferritin, transferrin (Tf), Tf saturation, soluble Tf receptor (sTfR), serum iron (SI), urea, parathormone, dialysis dose (Kt/V), dose of EPO administered (EPO), and absolute reticulocyte count. Multiple regression analyses were then performed to select the parameters that jointly provide the best prediction of %HYPO. RESULTS: Univariate analysis showed significant correlations between %HYPO and iron parameters (sTfR, Tf saturation, SI, and ferritin, in decreasing order), EPO, reticulocyte count, and CRP. Multivariate analysis yielded an equation showing that the variation of %HYPO is essentially associated with the combined changes in sTfR, CRP, and EPO dosage. CONCLUSIONS: %HYPO is a meaningful and inexpensive parameter that reflects the integrated effects of iron stores, inflammation, and erythropoietic stimulation on iron availability in hemodialyzed patients. Among iron exchange parameters, sTfR is the best predictor of %HYPO, followed by Tf saturation, SI, and ferritin. [less ▲]

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See detailLipids, risk factor in hemodialysed patients?
BOVY, Christophe ULg; Saint-Remy, Annie ULg; Juchmes, A. et al

in Nephrology Dialysis Transplantation (1998), 13

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