Effect of oral antioxidant supplementation on blood antioxidant status in trained thoroughbred horses

in Veterinary Journal (2005), 169(1), 65-74

The oxidant/antioxidant equilibrium of trained thoroughbred horses (n = 40) was assessed on three occasions during a period of three months under field conditions by blood antioxidant markers analysis, i ... [more ▼]

The oxidant/antioxidant equilibrium of trained thoroughbred horses (n = 40) was assessed on three occasions during a period of three months under field conditions by blood antioxidant markers analysis, i.e. plasma ascorbic acid (AA), plasma antioxidant capacity of water-soluble components (ACW), whole blood (GSH) and oxidised (GSSG) glutathione, plasma alpha-tocopherol and beta-carotene, plasma antioxidant capacity of lipid-soluble components (ACL), red blood cell superoxide dismutase (SOD) and glutathione-peroxidase activity (GPx) and plasma trace-elements, i.e. selenium (Se), copper (Cu), zinc (Zn). A control group of ten horses receiving a placebo and an antioxidant group of 30 horses orally supplemented with an antioxidant mixture were randomly formed. An antioxidant imbalance was observed after three months in the control group, reflected by a significant decrease in GSH, SOD, GPx, Se (P < 0.05) and a significant increase in GSSG (P < 0.05). The antioxidant supplement prevented GPx and Se decrease and significantly increased ACW, alpha-tocopherol, beta-carotene and ACL (P < 0.05). Significant sex- or age-related differences were found for AA, ACW, alpha-tocopherol, SOD, GPx and Se, and there were significant correlations between ACW-AA, ACL-alpha-tocopherol, GPx-Se, CPK-Se, CPK-alpha-tocopherol and CPK-Cu. This field study has shown that trained thoroughbred horses undergo significant changes of several blood antioxidant markers and that oral antioxidant supplementation might partially counterbalance these changes by improving the hydrophilic, lipophilic and enzymatic antioxidant blood capacity. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

Assessment of the oxidant-antioxidant blood balance in a field exercise test in Standardbred and eventing horses

in Equine & Comparative Exercise Physiology (2005), 2(4), 253-261

The aim of this study was to determüie which oxidant-antioxidant blood markers are of interest for a field exercise test (ET) performed on a racetrack. Healthy Standardbred herses (S: n = 12) and healthy ... [more ▼]

The aim of this study was to determüie which oxidant-antioxidant blood markers are of interest for a field exercise test (ET) performed on a racetrack. Healthy Standardbred herses (S: n = 12) and healthy eventing horses (E: n = 12) were investigated. Exercice was monitored by measuring velocity (V), heart rate (HR), and plasma lactate (LA). Whilst maximal LA did sot Biffer (11.8 ± 0.88 mmoll-1), maximal V (S: 12.3 ± 0.17ms-1 versus E: 11.1 ±0.24ms-1, P < 0,05) and final HR (S: 222 ±1 versus E: 203 ± 8 beats min-1, P < 0.03) were significantly différent between groups. Venous was collected at rest (R) prior to ET and The following oxidant-antioxidant markers were detennitted: uric acid (UA), ascorbic acid (AA), alpha-tocopherol (Vit E). vitamin A (Vit A), superoxide cüsmutase (SOB), glutaYhione peroxidase (GPx), glutathione (reduced: GSH and oxidized: GSS(r), glutathione redox ratio (GRR), copper (Cu), zinc (Zn) and sélénium (Se), uxidized proteins (Protox), lipid prrosides (Pool), antioxidant capacity of water-soluble comporteras (ACW) and antioxidant capacity of lipid-soluble components (ACW). The following markers were further determined 15 min (E15) after the ET:UA, ACW; AA, GSH, Proton, Pool, ACL. Standardbreds had significantly higher concentrations of ACW, GSH, ACL and Protox, whilst Se, Zn and SOI) were significantly lover than in eventing horses. Exercice induced a significant increase in ACW and UA. GSH decreaced in eventing horses and Pool significantly decreased in both horse groups. This study describes a field ET of high intensity for Standardbred and eventing horses, which could be performed by all animals tested. By sampling blond al rest and at E15, changes of thé hydrophilic antioxidant defence were partially assessed, whereas no interpretable changes of the lipophilic antioxidants and of oxidation markers (Protox, Pool) could be detected [less ▲]

Prévention des crises grâce à l’utilisation d’un concentré riche en fibres chez le cheval poussif

in Proceedings: Congrès Annuel A.V.E.F. (2005)

Gestion de l'environnement du cheval souffrant de troubles respiratoires

in Pratique Vétérinaire Equine (2004), 36(numéro spécial), 115-122

Several factors, namely infectious agents, may impair pulmonary defences. In such cases, inflammation and chronic respiratory diseases may result front inhalation of airborne dust. Appropriate management ... [more ▼]

Several factors, namely infectious agents, may impair pulmonary defences. In such cases, inflammation and chronic respiratory diseases may result front inhalation of airborne dust. Appropriate management of horse's environnent is consequently essentiel in the control of respiratory diseases. In this paper, distribution of inhaled particles, non specific pulmonary defences, respirable dust and lastly recommendations for environmental management will be presented [less ▲]

Training-induced changes in aerobic capacity assessed by VO2max and echocardiography in standardbred horses

in Lindsey, A. Abeyasekere; Frances, J.Barr (Eds.) Handbook of the 43rd Congress of the British Equine Veterinary Association (2004)

Part 2: Functional effects of restrictive pulmonary diseases

in Dunlop, Robert H; Malbert, Charles-Henri (Eds.) Veterinary Pathophysiology (2004)

Myeloperoxydase concentration in bronchoalveolar lavage from healthy and heavy horses

in Proceedings : 22nd Symposium of the Veterinary and Comparative Respiratory Society (2004)

Effet de l’entraînement et de l’intensité de l’exercice sur les marqueurs sanguins du stress oxydant chez le trotteur

in Proceedings: Congrès de l'Association Vétérinaire Equine Française (AVEF) (2004)

Activator protein-1 activity in bronchial brushing samples from horses with recurrent airway obstruction

in Proceedings of the 22nd Symposium of the Veterinary and Comparative Respiratory Society (2004)

Effects of glycopyrrolate inhalation on pulmonary function in heaves-affected horses in crisis

in Pflügers Archiv : European Journal of Physiology (2004), 447