References of "Art, Tatiana"
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See detailLe microdamier: un outil du futur pour le diagnostic de l’inflammation ?
Mignot, Clémence ULg; Fraipont, Audrey ULg; Richard, Eric et al

Poster (2009)

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See detailUpper airway dynamic endoscopy: are track and treadmill observations comparable ?
Van Erck, Emmanuelle ULg; Frippiat, Thibault ULg; Dupuis, Marie-Capucine ULg et al

in Tessier, Caroline; Gerber, Vincent (Eds.) Abstract book: 4th World Equine Airways Symposium (WEAS) (2009)

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See detailRespiratory inflammation in endurance horses
Van Erck, Emmanuelle ULg; Art, Tatiana ULg

in Tessier, Caroline; Gerber, Vincent (Eds.) Abstract book: 4th World Equine Airways Symposium (WEAS) (2009)

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See detailExpression microarrays in equine sciences
Ramery, Eve ULg; Closset, Rodrigue; Art, Tatiana ULg et al

in Veterinary Immunology and Immunopathology (2009), 127(3-4), 197-202

Microarrays have become an important research tool for life science researchers. Expression microarrays are capable of profiling the gene expression pattern of tens of thousands of genes in a single ... [more ▼]

Microarrays have become an important research tool for life science researchers. Expression microarrays are capable of profiling the gene expression pattern of tens of thousands of genes in a single experiment. It appears to be the platform of choice for parallel gene expression profiling. Various equine-specific gene expression microarrays have been generated and used. However, homologous microarrays are not yet commercially available for the horse. An alternative is the use of heterologous microarrays, mainly microarrays specific for mice or humans. Although the use of microarrays in equine research is still in its infancy, gene expression microarrays have shown their potential in equine research. This review presents the previous, current and potential use of expression microarrays in equine research. [less ▲]

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See detailAssociation between lower airway inflammation and EIPH in 196 standarbred racehorses
Simon, Valérie ULg; Art, Tatiana ULg; Ramery, Eve ULg et al

in Tessier, Caroline; Gerber, Vincent (Eds.) Abstract book: 4th World Equine Airways Symposium (WEAS) (2009)

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See detailAerosol administration of cefquinome in healthy horses – effect on pulmonary function and lung inflammation
Art, Tatiana ULg; Ramery, Eve ULg; Fraipont, Audrey ULg et al

in Tessier, Caroline; Gerber, Vincent (Eds.) Abstract book: 4th World Equine Airways Symposium (WEAS) (2009)

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See detailPTX3: a new marker for local inflammation ?
Ramery, Eve ULg; Bureau, Fabrice ULg; Art, Tatiana ULg et al

in Proceedings of the 11th ECVCP congress, Thessaloniki, Grece (2009)

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See detailEpithelial expression of mRNA and protein for IL-6, IL-10 and TNF-alpha in endobronchial biopsies in horses with recurrent airway obstruction.
Riihimäki, Miia; Raine, Amanda; Pourazar, Jamshid et al

in BMC Veterinary Research (2008), 4

BACKGROUND: The aim of this study was to evaluate the contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of cytokines of innate immunity IL-6, IL-10 and ... [more ▼]

BACKGROUND: The aim of this study was to evaluate the contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of cytokines of innate immunity IL-6, IL-10 and TNF-alpha, in horses with Recurrent Airway Obstruction (RAO) during exacerbation and in remission. RESULTS: Despite marked clinical and physiologic alterations between exacerbation and after remission in the RAO horses no differences were detected in either cytokine mRNA or protein levels. Moreover, the expression of investigated cytokines in RAO horses on pasture did not differ from controls.In comparing real-time PCR analysis to results of immunohistochemistry only IL-10 mRNA and protein levels in RAO horses on pasture were significantly correlated (rs = 0.893, p = 0.007). Curiously, in controls examined on pasture the TNF-alpha protein level was positively correlated to IL-10 mRNA expression (rs = 0.967, p = 0.007) and negatively correlated to IL-6 mRNA expression (rs = -0.971, p = 0.001). CONCLUSION: Given the complementary relationship of assessing cytokines directly by immunohistochemistry, or indirectly by PCR to mRNA, the lack of significant changes in either mRNA or protein levels of IL-6, IL-10 or TNF-alpha mRNA in RAO horses in exacerbation suggests that these particular cytokines in bronchial tissue may not play a substantive role in the active inflammation of this disease. To support this contention further studies examining time dependency of expression of IL-6, IL-10 or TNF-alpha are needed, as is expansion of the range of cytokines to include other key regulators of airway inflammation. [less ▲]

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See detailEvaluation de la condition physique chez le cheval d’endurance : comparaison d’un test de terrain adapté et d’un test sur tapis roulant
Fraipont, Audrey ULg; Van Erck, Emmanuelle; Toussaint, Marie et al

in 36èmes Journées AVEF (2008)

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See detailWhat do we know about the poor performance horse ?
Art, Tatiana ULg; Van Erck, Emmanuelle ULg

in Lindner, Arno (Ed.) The Acute poorly performing sport horse (2008)

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See detailEtude de l'administration par inhalation de cefquinome chez le cheval sain
Art, Tatiana ULg; Van Erk, E.; Ramery, Eve ULg et al

in Pratique Vétérinaire Equine (2008), 40

Cefquinome aerosol is sometimes used in horse suffering from respiratory infections. However, harmlessness and validity of the method has never been studied. This work aimed at controlling the lack of ... [more ▼]

Cefquinome aerosol is sometimes used in horse suffering from respiratory infections. However, harmlessness and validity of the method has never been studied. This work aimed at controlling the lack of pulmonary effects of cefquinome when administered through inhalation in healthy horses and at comparing the cefquinome concentrations obtained in broncho-alveolar lavage after aerosol, intramuscular and intravenous administrations. A single aerosol of cefquinome did not induce any detectable side effect in healthy horses and allowed to obtain broncho-alveolar concentrations higher than obtained with intravenous and intramuscular injection. These results should now be completed by further studies, especially on horses suffering from respiratory disease and bronchial hyperreactivity [less ▲]

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See detailPartial divergence of cytokine mRNA expression in bronchial tissues compared to bronchoalveolar lavage cells in horses with recurrent airway obstruction.
Riihimaki, M.; Raine, Amanda; Art, Tatiana ULg et al

in Veterinary Immunology and Immunopathology (2008), 122(3-4), 256-64

The aim of this study was to investigate mRNA levels of cytokines in bronchial epithelium in horses with recurrent airway obstruction (RAO) during acute crisis and remission. Additionally, cytokine mRNA ... [more ▼]

The aim of this study was to investigate mRNA levels of cytokines in bronchial epithelium in horses with recurrent airway obstruction (RAO) during acute crisis and remission. Additionally, cytokine mRNA levels in endobronchial biopsies and bronchoalveolar lavage (BAL) cells were compared. Seven RAO horses were examined while in respiratory crisis following provocation and again while in remission after 2 months on pasture, during which time six healthy horses on pasture were also examined. Quantitative real-time PCR (RT-PCR) was used to assess mRNA expression for cytokines IL-5, IL-6, IL-8, IL-10, IL-17 and transforming growth factor beta1 (TGF-beta1) in endobronchial biopsies and bronchoalveolar lavage. Expression of IL-8 mRNA was significantly upregulated during crisis in both endobronchial biopsies and BAL cells (p=0.036), while there was a similar trend for upregulation of IL-10 mRNA only in BAL cells that approached significance (p=0.059). Moreover, during crisis the expression of IL-8 mRNA in BAL cells was positively correlated to relative IL-6 mRNA expression (r(s)=0.971, p=0.001) and bronchial epithelial expression of IL-10 and TGF-beta1 mRNA were positively correlated (r(s)=0.943, p=0.005). In comparing the relationship of mRNA expression in BAL to biopsy in individual RAO horses, there was a positive correlation with IL-6 to IL-8 mRNA expression in BAL during respiratory crisis (r(s)=0.971, p=0.001) that also correlated positively with IL-8 expression in biopsies on pasture (r(s)=0.986, p<0.0001 for both). Regarding RAO horses at pasture versus controls neither the cytokine mRNA levels in endobronchial biopsy nor in BAL cells differed significantly. These results further support previous findings that IL-8 mRNA in both BAL cells and bronchial epithelium is upregulated in RAO horses during crisis. However, apart from IL-8, it appears that expression of other cytokines, including IL-5, IL-6, IL-10, IL-17 and TGF-beta1 in bronchial epithelium does not necessarily mirror cytokine expression in BAL cells in individual horses with RAO. Accordingly, examination of markers of inflammation in endobronchial tissue provides complementary but not necessarily identical information to that obtained in BAL cells. Given the potential for repeated sampling over time bronchial biopsy can serve as an invaluable additional tool for investigation of time-dependent changes in inflammatory process in this animal model of asthma. [less ▲]

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See detailHunting for a key to the enigma of heaves in the black box of the white cells
Art, Tatiana ULg; Bureau, Fabrice ULg; Robinson, N Edward

in Veterinary Journal (2008), 177(3), 307-308

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See detailRelevance of using a human microarray to study gene expression in heaves-affected horses.
Ramery, Eve ULg; Closset, Rodrigue; Bureau, Fabrice ULg et al

in Veterinary Journal (2008), 177(2), 216-221

Environmental causes of heaves are well described, but the molecular mechanisms of the disease remain unclear. Previous studies have highlighted the implications of variations in gene expression, most ... [more ▼]

Environmental causes of heaves are well described, but the molecular mechanisms of the disease remain unclear. Previous studies have highlighted the implications of variations in gene expression, most using reverse transcription polymerase chain reaction (RT-PCR). This well-known technique limits the number of genes that can be studied in a single assay. Microarray appears to be a valuable tool to by-pass this limitation, but so far there has been no equine-specific microarray available on the market. The present study was performed to determine whether a human microarray could be used to study gene expression in nucleated cells originating from peripheral blood and bronchoalveolar lavage fluid (BALF) in heaves-affected horses. With a four-fold cut-off, a total of 46 candidates were identified with differentially regulated genes between heaves-affected horses and controls. A real-time quantitative RT-PCR (RT-QPCR) conducted on a selection of genes, determined on the basis of previous publications, was used to validate the microarray results. The microarray failed to detect the presence of interleukin (IL)-1beta and IL-8 mRNA in the nucleated cells from BALF otherwise confirmed by real-time RT-QPCR. Although some candidate genes have been identified using this method, a complete expression profile of genes related to heaves could not be obtained with the use of the human microarray. [less ▲]

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See detailEffects of exercise and oral antioxidant supplementation enriched in (n-3) fatty acids on blood oxidant markers and erythrocyte membrane fluidity in horses
De Moffarts, Brieuc; Portier, Karine; Kirschvink, Nathalie et al

in Veterinary Journal (2007), 174(1), 113-121

The aim of this study was to investigate in a placebo-controlled field study the effect of a (n - 3)-vitamin supplementation on erythrocyte membrane fluidity (ENIF), oxidant/antioxidant markers and ... [more ▼]

The aim of this study was to investigate in a placebo-controlled field study the effect of a (n - 3)-vitamin supplementation on erythrocyte membrane fluidity (ENIF), oxidant/antioxidant markers and plasmatic omega 3/omega 6 fatty acid ratio (FAR) in 12 eventing horses. Venous blood was sampled at rest before (PRE) and after (POST) a three week treatment period with either the supplement (group S, n = 6) or a placebo (group P, n = 6) as well as after 15 min (POST E15') and 24 h (POST E24h) after a standardised exercise test. The following markers were analysed: EMF, plasma antioxidant capacity of water and lipid soluble components, ascorbic acid, uric acid (UA), glutathione (reduced: GSH, oxidised: GSSG), vitamin E (Vit E), beta-carotene, glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity, selenium, copper (Cu), zinc (Zn), oxidised proteins (Protox), lipid peroxides (Pool) and FAR. EMF did not differ between group S and P after treatment, but GPx remained unchanged in group S whereas it decreased in group P and plasma Cu/Zn ratio remained unchanged whereas it increased in group P. FAR were significantly increased in group S. Exercise induced a significant decrease of EMF (POST vs. E24h) in both groups, but which was significantly lower at E15' in group S than in group P. Exercise induced a significant increase of UA and ACW (POST vs. E15') and Protox (POST vs. E24h) in both groups. An exercise-related decrease in GSH and Pool (POST vs. E15') was found in group P, whereas Vit E and FAR (POST vs. E24h) significantly decreased in both groups. The study showed that exercise induced a decrease in ENIF in horses associated with changes of blood oxidative balance. The (omega-3)vitamin supplementation tested improved the oxidative balance poorly but delayed the exercise-induced decrease of EMF and increased the FAR. [less ▲]

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See detailBilan medico-sportif du yearling a l’entrainement
Toussaint; Fraipont, Audrey ULg; Wagemans, Marie-Christine et al

in 35èmes Journées AVEF (2007)

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See detailCurrent treatment of respiratory inflammatory disorders in the horse
Lekeux, Pierre ULg; Van Erck, Emmanuelle; Art, Tatiana ULg

in XVII. Tagung über Pferdekrankheiten im Rahmen der EQUITANA (2007)

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See detailPotential use of micro-array technology (bio-puce) in the diagnosis of inflammatory disorders in the horse
Lekeux, Pierre ULg; Thomas, A.; Ramery, Eve ULg et al

in XVII. Tagung über Pferdekrankheiten im Rahmen der EQUITANA (2007)

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See detailEffect of exercise and training on oxygen transport in healthy standardbred horses
Kirschvink, Nathalie; Cambier, Carole ULg; de Moffarts, Brieuc et al

in Journal of Veterinary Internal Medicine (2007), 21

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See detailPulmonary function and antimicrobial concentration after marbofloxacin inhalation in horses.
Art, Tatiana ULg; de Moffarts, B.; Bedoret, Denis ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2007), 161(10), 348-350

Detailed reference viewed: 24 (4 ULg)