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See detailAnneaux, cibles ou cocardes
Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (1998), 53(3), 117-118

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See detailL1-protein in incipient lymphocyte-depleted graft-versus-host disease. Expression in keratinocytes and coexpression with Factor XIIIa in dermal cells
Pierard, Gérald ULg; Tassoudji, Nazli ULg; Arrese Estrada, Jorge ULg et al

in Turkish Journal of Dermatology = Dermatopatoloji Dergisi (1998), 7

With the introduction of effective immunosuppressive regimens some cutaneous rashes following bone marrow transplant may appear histologically unremarkable. We report three cases of cyclosporin-abated ... [more ▼]

With the introduction of effective immunosuppressive regimens some cutaneous rashes following bone marrow transplant may appear histologically unremarkable. We report three cases of cyclosporin-abated cutaneous graft-versus-host reaction (GVHR) where the most straightful histologic clue was the epidermal L1-protein (calprotectin) expression revealed by a positive immunolabelling using the Mac 387 antibody. The epidermis looked otherwise normal and inflammatory cells were scant in the dermis. The expression of calprotectin by keratinocytes occurred early in cutaneous GVHR. In addition, CD45RO-positive T memory lymphocytes were exceedingly rare in the dermis while a few Mac 387-positive monocytes coexpressed Factor XIIIa immunoreactivity. Hyperplasia of the Factor XIIIa-positive dendrocytic population was obvious. Calprotectin and Factor XIIIa immunolagellings should be regarded as a diagnostic adjunct in lymphocyte-depleted cutaneous GVHR. Calprotectin positivity of the epidermis is indicative although not specific for such condition. However, its combination with a low lymphocytes/monocytes ratio in the dermis which is enriched in plup dendrocytes is almost diagnostic. [less ▲]

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See detailNaevocyte Triggering by Recombinant Human Growth Hormone
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg et al

in Journal of Pathology (The) (1996), 180(1), 74-79

The influence of growth hormone and insulin-like growth factor I on human melanocytes is being increasingly recognized. Clinical evidence has shown that when recombinant human growth hormone (hGH) is ... [more ▼]

The influence of growth hormone and insulin-like growth factor I on human melanocytes is being increasingly recognized. Clinical evidence has shown that when recombinant human growth hormone (hGH) is administered to children of short stature, the growth of melanocytic naevi is boosted. This study was conducted on 56 hGH-triggered naevi and nine similar lesions excised before or after hGH therapy for hypopituitarism and Turner's syndrome. A series of 40 naevi excised from age-matched healthy children served as controls. Atypicality of naevocytes was investigated using image analysis, AgNOR counts, immunohistochemistry (HMB-45, NKI-C3, Ki-67, anti-bcl-2-oncoprotein), and DNA flow cytometry. The data associate hGH treatment with anisokaryosis and increased AgNOR and Ki-67 counts in naevocytes. The same cells also show abnormal patterns of HMB-45 immunolabelling. These indications of naevocyte activation were not suggestive of malignant transformation. hGH-triggered melanocytomas should be added to the list of atypical melanocytic naevi. The long-term evolution of these lesions remains unknown and the potential risk of malignant transformation awaits careful evaluation. [less ▲]

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See detailFactor Xiiia-Positive Dendrocytes and Proliferative Activity of Cutaneous Cancers
Pierard-Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Nikkels, Arjen ULg et al

in Virchows Archiv : An International Journal of Pathology (1996), 429(1), 43-48

Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages and ... [more ▼]

Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages and antigen-presenting cells. Factor XIIIa, other tissue transglutaminases, alpha 2-macroglobulin and tumour necrosis factor-alpha represent a complex network of mediators influencing tumour progression in the skin. In the present study we searched for the presence of dendrocytes and alpha 2-macroglobulin deposits inside and in the vicinity of cutaneous carcinomas (90 basal cell carcinomas and 46 squamous cell carcinomas) and malignant melanomas (69 primary and 28 metastatic tumours). We also studied the proliferation of the same neoplasms by Ki-67 immunohistochemistry. Dendrocytes were numerous, abutting on and infiltrating most basal cell carcinomas and thin malignant melanomas. In contrast, they were present in only low numbers or even absent in thick primary malignant melanomas and in their metastases. They appeared unmodified around squamous cell carcinomas compared with the surrounding skin. Extracellular deposits of alpha 2-macroglobulin were often found in locations where dermal dendrocytes were numerous. No correlation was found between the Ki-67 indices of carcinomas and the density of peritumoral dendrocytes. In contrast, negative relationships were found between the Ki-67 indices and the number of dendrocytes present inside basal cell carcinomas and thin malignant melanomas. This study has yielded circumstantial evidence to link the density of factor XIIIa-positive dendritic cells and a low proliferative rate of neoplastic cells in basal cell carcinomas and malignant melanomas. [less ▲]

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See detailThe frequency of cutaneous vasculitis is not increased in patients with rheumatoid arthritis treated with methotrexate
Kaye, O.; Beckers, C. C.; Paquet, P. et al

in Journal of Rheumatology (1996), 23(2), 253-257

OBJECTIVE: To analyse the frequency, type, and immunohistological features of clinical cutaneous vasculitis developing in patients with rheumatoid arthritis (RA) treated or not with methotrexate as well ... [more ▼]

OBJECTIVE: To analyse the frequency, type, and immunohistological features of clinical cutaneous vasculitis developing in patients with rheumatoid arthritis (RA) treated or not with methotrexate as well as their demographic, clinical and biological characteristics. METHODS: Ninety-one patients with RA receiving 9.5 mg/wk of methotrexate (MTX) were compared for an average observation time of 18 months to 130 matched patients with RA treated with various drugs excluding MTX. RESULTS: Whether receiving MTX or not, 5.4% of patients with RA developed a clinical cutaneous vasculitis. There were significant differences between both groups for 2 variables only: a higher percentage of polyneuropathies and a higher level of immune complex-plasma levels in non-MTX patients. The immunohistological analysis did not differentiate both groups. CONCLUSION: The percentage of cutaneous vasculitis that developed under MTX therapy was not different from that occurring as a natural complication of longstanding severe RA. [less ▲]

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See detailPrimary Systemic Amyloidosis - A report of 2 cases
Dezfoulian, Bita ULg; Arrese Estrada, Jorge ULg; Fernandez, A. et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1996), 192

We report 2 cases of primary systemic amyloidosis. A monoclonal gammopathy was confirmed at the postmortem examination of the first patient. An extensive search for evidence of chronic infection ... [more ▼]

We report 2 cases of primary systemic amyloidosis. A monoclonal gammopathy was confirmed at the postmortem examination of the first patient. An extensive search for evidence of chronic infection, inflammation, neoplasms and paraproteinemia was conclusively negative in the other patient. The recognition of cutaneous signs of primary systemic amyloidosis is crucial to insure a rapid management aimed at postponing the fatal issue of the disease. [less ▲]

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See detailGranuloma tuberculoide post-herpético en un paciente con leucemia linfocítica crónica
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Medicina Cutanea Ibero-Latino-Americana (1996), 24

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See detailFungi die onychomycosis veroorzaken in Nederland
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Nederlands Tijdschrift voor Geneeskunde (1995), 139

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See detailMacrofagos e factor a de necrose tumoral na necrolise epidermica toxica
Paquet, Philippe ULg; Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg et al

in Arquivos de Dermatologia (1995), 2

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular ... [more ▼]

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular inflamatorio varió dependiendo del estado de la enfermedad. La principal característica constante fue la importante implicación de la línea monocito-macrófago, incluyendo dendrocitos factor XIIIa+ HLA-DR+ y macrófagos CD68+ Mac 387+, antes y durante la necrosis epidérmica. El número de linfocitos CD4+ y CD8+ era comparativamente reducido. Ello se asociaba con un denso marcaje para el factor de necrosis tumoral alfa en la epidermis. CONCLUSIONES: Las células de estirpe monocito-macrófago superan en nùmero ampliamente a los linfocitos en las lesiones de la necrólisis epidérmica tóxica. El factor de necrosis tumoral alfa es problablemente una de las citocinas principales responsables de la necrosis. [less ▲]

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See detailAcquired Persistent Atypical Lentigines as a Failure of 5-Methoxypsoralen-Containing Sunscreens in the Photochemoprotection from Ultraviolet-Radiation-Induced Damage
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1995), 190(4), 338-340

Acquired persistent atypical lentigines are pigmentary lesions that are unusual both clinically and microscopically. They occur in young adults with photosensitive skin using 5-methoxypsoralen-containing ... [more ▼]

Acquired persistent atypical lentigines are pigmentary lesions that are unusual both clinically and microscopically. They occur in young adults with photosensitive skin using 5-methoxypsoralen-containing sunscreens during sunbathing. Their biologic behavior is benign, but there are grounds for concern regarding the carcinogenic risk in these patients. [less ▲]

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See detailInverse Modulation of Intraepithelial Langerhans' Cells and Stromal Macrophage/Dendrocyte Populations in Human Papillomavirus-Associated Squamous Intraepithelial Lesions of the Cervix
Al-Saleh, Walid; Delvenne, Philippe ULg; Arrese Estrada, Jorge ULg et al

in Virchows Archiv : An International Journal of Pathology (1995), 427(1), 41-8

Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal ... [more ▼]

Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal macrophages/dendrocytes by immunohistochemistry using anti-S100, -L1, -CD68 and -factor XIIIa antibodies. Human papillomavirus (HPV) detection was performed in all cases by using first a mixture of DNA probes for 14 HPV types commonly found in anogenital biopsies at low stringency conditions (Tm -40 degrees C) and by reanalyzing the tissues at high stringency (Tm -10 degrees C) with HPV 6/11, 16/18 and 31/33/35 biotinylated probe cocktails and individual digoxigenin-labelled probes. SILs and metaplastic tissues were significantly associated with a depletion of S100-positive intraepithelial Langerhans' cells when compared with normal epithelium. In contrast, there was a significant increase in L1-positive stromal macrophages in SIL biopsies compared with normal or metaplastic cervix. A significantly higher density of CD68-positive macrophages was also observed in high-grade SILs compared with normal or metaplastic biopsies and with low-grade SILs. The density of factor XIIIa-positive dendrocytes was found to be higher in SILs compared with metaplastic tissues and in high-grade SILs when compared with normal cervical biopsies. No specific relationship was found between the densities of these cells and the HPV type detected in SILs separated into low grade and high grade. The significance of this inverse modulation of intraepithelial Langerhans' cells and stromal macrophages/dendrocytes in normal and SIL biopsies is discussed in relation to HPV infection and malignant transformation. [less ▲]

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See detailMacrophages and Tumor Necrosis Factor Alpha in Toxic Epidermal Necrolysis
Paquet, Philippe ULg; Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg et al

in Archives of Dermatology (1994), 130(5), 605-608

BACKGROUND: We studied the immunopathologic characteristics of five cases of toxic epidermal necrolysis by using a large panel of antibodies. OBSERVATIONS: The pattern and amount of the inflammatory cell ... [more ▼]

BACKGROUND: We studied the immunopathologic characteristics of five cases of toxic epidermal necrolysis by using a large panel of antibodies. OBSERVATIONS: The pattern and amount of the inflammatory cell infiltrate varied according to the stage of the disease. The main constant feature was the prominent involvement of the monocyte-macrophage lineage, including factor XIIIa+HLA-DR+ dendrocytes and CD68+ Mac 387+ macrophages, before and during the epidermal necrosis. The number of CD4+ and CD8+ lymphocytes was comparatively small. This was associated with a dense labeling of the epidermis for tumor necrosis factor alpha. CONCLUSIONS: Cells of the monocyte-macrophage lineage largely outnumber lymphocytes in the lesions of toxic epidermal necrolysis. Tumor necrosis factor alpha is likely a major cytokine that is responsible for necrosis. [less ▲]

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See detailMacrofagos y factor de necrosis tumoral alfa en la necrolisis epidermica toxica
Paquet, Philippe ULg; Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg et al

in Archives of Dermatology (1994), 5

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular ... [more ▼]

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular inflamatorio varió dependiendo del estado de la enfermedad. La principal característica constante fue la importante implicación de la línea monocito-macrófago, incluyendo dendrocitos factor XIIIa+ HLA-DR+ y macrófagos CD68+ Mac 387+, antes y durante la necrosis epidérmica. El número de linfocitos CD4+ y CD8+ era comparativamente reducido. Ello se asociaba con un denso marcaje para el factor de necrosis tumoral alfa en la epidermis. CONCLUSIONES: Las células de estirpe monocito-macrófago superan en nùmero ampliamente a los linfocitos en las lesiones de la necrólisis epidérmica tóxica. El factor de necrosis tumoral alfa es problablemente una de las citocinas principales responsables de la necrosis. [less ▲]

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See detailPhenotypic heterogeneity of the fibroblast-like cells in the dermis
Pierard-Franchimont, Claudine ULg; Fazaa, B.; Benzarti, H. et al

in Giornale Internazionale di Dermatologia Pediatrica (1994), 6(1), 7-13

The fibroblast-like cell population of the dermis is heterogeneous. The name "fibroblast" appears to be out-dated and should be replaced by terms reflecting with precision the immunophenotype of the cells ... [more ▼]

The fibroblast-like cell population of the dermis is heterogeneous. The name "fibroblast" appears to be out-dated and should be replaced by terms reflecting with precision the immunophenotype of the cells. Among them, dendrocytes type I (Factor XIIIa - positive) and dendrocytes type II (CD34 - positive) are involved in a wealth of pathologic conditions. [less ▲]

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See detailEvaluation quantitative de l'érythème par colorimétrie. Effets de l'histamine de corticostéroïdes et d'extraits végétaux
Arrese Estrada, Jorge ULg; Nikkels, Arjen ULg; El Fekih, N. et al

in Journal d'Actualités Médicales Belges (1993), 5

L'évaluation de l'érythème est difficile et souvent aléatoire en clinique. Afin d'étudier la couleur des téguments, la colorimétrie est proposée depuis quelques années. Elle permet plus de rigueur. En ... [more ▼]

L'évaluation de l'érythème est difficile et souvent aléatoire en clinique. Afin d'étudier la couleur des téguments, la colorimétrie est proposée depuis quelques années. Elle permet plus de rigueur. En tous cas, elle permet d'aligner des chiffres dont les variations peuvent être étudiées dans le temps. Le présent travail a permis de tester, de "calibrer" la méthodologie colorimétrique dans le domaine de l'érythème cutané. D'une part, l'effet vasodilatateur (érythémateux) de l'histamine, de l'autre, le blanchiment induit par l'application de topiques corticoïdes et phytopharmaceutiques ont été mesurés et discutés. [less ▲]

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See detailCD68 and Factor XIIIa expressions in granular-cell tumor of the skin
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard-Franchimont, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1993), 186(2), 106-108

Immunohistochemical and electron microscopic studies support a Schwann cell origin for most of the granular-cell tumors of the skin. We studied 9 granular-cell tumors by immunohistochemistry, using ... [more ▼]

Immunohistochemical and electron microscopic studies support a Schwann cell origin for most of the granular-cell tumors of the skin. We studied 9 granular-cell tumors by immunohistochemistry, using antibodies to CD68, S-100 proteins, factor XIIIa, L1 antigen, desmin and vimentin. The CD68 monocyte-macrophage-associated lysosomal antigen was expressed in granular cells which however had no Mac 387 reactivity. The 'satellite fibroblasts' were factor XIIIa-positive similarly to dendrocytes and perineurial cells. Our study reveals the lack of specificity of CD68 antibody to identify macrophages. It also presents granular cell tumor of the skin as an exception in the group of schwannomas by the presence of factor XIIIa-positive cells inside the neoplasm. [less ▲]

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See detailTumeurs cutanées à papillomavirus. Intérêt de l'immunopathologie et de l'hybridation in situ
Pierard-Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Fazaa, B. et al

in Revue Médicale de Liège (1991), 46(9), 480-485

On connaît actuellement une soixantaine de papillomavirus humains. Ils sont responsables des verrues, des condylomes, de papillomes ainsi que de lésions maculeuses paucisymptomatiques. Certaines tumeux ... [more ▼]

On connaît actuellement une soixantaine de papillomavirus humains. Ils sont responsables des verrues, des condylomes, de papillomes ainsi que de lésions maculeuses paucisymptomatiques. Certaines tumeux épithéliales, localement invasices ou franchement malignes sont également le reflet d'une infection par certains de ces papillomavirus. Nous présentons une brève revue des méthodes cliniques et histologiques qui peuvent être mises en oeuvre pour le dépistage et l'identification de ces atteintes virales. [less ▲]

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See detailLes auto-anticorps et le profil immunopathologique des lupus érythémateux
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (1991), 46(5), 279-285

Nous présentons une synthèse de la signification diagnostique, clinique et pronostique d'une série d'auto-anticorps apparaissant dans les diverses formes de lupus érythémateux.

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See detailLe système immunitaire cutané et le photovieillissement
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (1991), 46(3), 158-163

La connaissance du système immunitaire cutané a beaucoup progressé durant les dernières années. Considérée auparavant comme un organe passif de protection, on sait aujourd'hui que la peau est un organe ... [more ▼]

La connaissance du système immunitaire cutané a beaucoup progressé durant les dernières années. Considérée auparavant comme un organe passif de protection, on sait aujourd'hui que la peau est un organe immunocompétent. Le vieillissement cutané et l'exposition à la lumière ultraviolette ont une influence importante sur le système immunitaire cutané. Après une brève actualisation et description des cellules immunocompétentes de l'épiderme et du derme, nous considérerons la modulation du système immunitaire cutané liée au photovieillissement. [less ▲]

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See detailImmunohistochemical expression of epidermal growth factor receptors in nuclei of a subpopulation of keratinocytes and sweat gland cells.
Pierard, Claudine ULg; Colige, Alain ULg; Arrese Estrada, Jorge ULg et al

in Dermatologica (1991), 183(1), 7-9

We have raised a polyclonal antibody to the 170-kD epidermal growth factor receptor. We found an intercellular pattern of immunoreactivity in the epidermis as well as a positivity of the cytoplasm of ... [more ▼]

We have raised a polyclonal antibody to the 170-kD epidermal growth factor receptor. We found an intercellular pattern of immunoreactivity in the epidermis as well as a positivity of the cytoplasm of keratinocytes and eccrine secretory cells. In some samples, a nuclear labelling was evidenced in these type of cells. There is a close resemblance in the topographical distribution of these cells with nuclear labelling and those synthesizing DNA under phytohaemagglutinin stimulation. [less ▲]

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