References of "Arrese Estrada, Jorge"
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See detailImmunohistochemical detection of incipient melanoma micrometastases. Relationship with sentinel lymph node involvement.
Claessens, Nadine; Pierard, Gérald ULg; Pierard, Claudine ULg et al

in Melanoma Research (2005), 15(2), 107-10

It is acknowledged that tumour thickness, ulceration and lymph node invasion are the most important prognostic factors for cutaneous melanomas. Other histopathological features may also be informative ... [more ▼]

It is acknowledged that tumour thickness, ulceration and lymph node invasion are the most important prognostic factors for cutaneous melanomas. Other histopathological features may also be informative. The aim of this study was to ascertain whether immunohistochemical methods can improve the detection of satellite micrometastases in primary melanoma patients. In addition, the predictive value of cutaneous satellite micrometastases for sentinel lymph node involvement was evaluated. A total of 265 primary cutaneous melanomas and 68 of the respective sentinel nodes were studied using a panel of seven antibodies directed against melanocyte-related antigens. In 12.4% of the 265 cases, small satellite micrometastases were detected by immunohistochemistry. Sentinel lymph node metastases were found in 14% of the 68 cases. Invasion of the sentinel lymph node correlated with the presence of cutaneous satellite micrometastases. It is concluded that the presence of cutaneous satellite micrometastases may be an indication for the performance of sentinel lymph node biopsy, and this finding calls for a closer follow-up of these patients. [less ▲]

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See detailVascularity and fractal dimension of the dermo-epidermal interface in guttate and plaque-type psoriasis.
Uhoda, Isabelle; Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2005), 210(3), 189-93

BACKGROUND: Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions ... [more ▼]

BACKGROUND: Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions. OBJECTIVE: To determine and compare the variations in shape of the dermo-epidermal junction and the size of the superficial vessels in psoriatic lesions. METHOD: The relative microvasculature area and the fractal dimension D of the dermo-epidermal interface were measured inside and outside growth-stunted guttate lesions (n = 22) and expanding plaques (n = 37) in psoriasis of the trunk. RESULTS: The median D values of the dermo-epidermal interface were significantly larger (p < 0.01) in psoriatic plaques (D = 1.15) than in guttate lesions (D = 1.08), and these D values on lesional skin were significantly larger (p < 0.01) than in the uninvolved skin (D = 1.03). The microvasculature was significantly (p < 0.01) more developed in lesional (plaque: 13%, guttate: 8.20%) than in uninvolved skin (3.60 and 3.85%). No correlations were found between the relative microvasculature areas and the D values of the dermo-epidermal interface, both in the uninvolved and lesional skins of each psoriatic type. CONCLUSION: The absence of a relationship between modulations of the dermo-epidermal junction and vascular hyperplasia, both in expanding and stable psoriasis lesions, suggests that these events are regulated by different mechanisms and do not depend on each other. [less ▲]

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See detailUn nuevo enfoque sobre la epidemioloiga de las onicomicosis.
Arrese Estrada, Jorge ULg; Valverde, J.; Pierard, Gérald ULg

in Revista Iberoamericana de Micología (2005), 22

Onychomycoses represent a group of nail affections caused by one or more fungi. Whether aging represents a risk factor for developing onychomycosis, remains a question. In the present work, we studied the ... [more ▼]

Onychomycoses represent a group of nail affections caused by one or more fungi. Whether aging represents a risk factor for developing onychomycosis, remains a question. In the present work, we studied the variations in frequency and prevalence of onychomycoses and non-mycotic onychodystrophies according to age. Our results show that there is an increase in the frequency and prevalence of onychomycoses and non-mycotic onychodystrophies predominantly in patients over forty years of age. [less ▲]

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See detailLes onychomycoses au-delà de la bagatelle, des fadaises et des "carabistouilles".
Pierard, Gérald ULg; Bourguignon; Arrese Estrada, Jorge ULg et al

in Dermatologie Actualité (2005), 91

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See detailGenophotodermatoses.
Arrese Estrada, Jorge ULg; Henry, Frédérique ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60 Suppl 1

Genophotodermatoses can result from a defect in melanin synthesis, a defect in DNA repair or a congenital photosensibility.

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See detailLe carcinome de Merkel.
Barile, Paola ULg; Leroy, Cécile ULg; Bolle, S. et al

in Journal Français d'Ophtalmologie (2004), 27(4), 432-6

Merkel cell carcinoma is a neuroendocrine tumor of the skin, originating from neuroendocrine cells. A case report of Merkel cell carcinoma, discovered in a 77-Year-old woman, was diagnosed and confirmed ... [more ▼]

Merkel cell carcinoma is a neuroendocrine tumor of the skin, originating from neuroendocrine cells. A case report of Merkel cell carcinoma, discovered in a 77-Year-old woman, was diagnosed and confirmed on a biopsy. Diagnostic and therapeutic orientations of this unusual but malignant tumor are described. [less ▲]

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See detailHistomycologie de la biodiversité des onychomycoses
PIERARD, Gérald ULg; ARRESE ESTRADA, Jorge ULg; QUATRESOOZ, Pascale ULg

in Baran, R.; PIERARD, Gérald (Eds.) Onychomycoses (2004)

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See detailSynopsis des dermatomycoses invasives chez l'immunodéprimés.
Quatresooz, Pascale ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (2004), 31

The immune system plays a prominent role in the defense against a wide variety of pathogen fungi. Thus, the immunocompromised patient becomes a potential victim of mycoses originating from the skin. These ... [more ▼]

The immune system plays a prominent role in the defense against a wide variety of pathogen fungi. Thus, the immunocompromised patient becomes a potential victim of mycoses originating from the skin. These mycoses may become invasive and a fatal issue is possible. In other circumstances, the inoculation site is pulmonary or digestive, and the cutaneous lesions represent secondary localizations. [less ▲]

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See detailComparative clinicopathological manifestations of human aspergillosis. A review.
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg

in Exogenous Dermatology : Physical, Chemical, Biological (2004), 3

Aspergillus species are important fungi of the environment, some of them being responsible for severe infections. Many distinct diseases form the human aspergillosis spectrum. The pathomechanisms differ ... [more ▼]

Aspergillus species are important fungi of the environment, some of them being responsible for severe infections. Many distinct diseases form the human aspergillosis spectrum. The pathomechanisms differ according to the affected organ and the immune status of the patient. The fungus can be responsible for allergic reactions. It may also act as a saprophytic colonizer of air spaces. Infection may remain limited to the skin and nails. It may also be invasive, particularly in immunocompromised patients, in the lungs, paranasal sinus and gastro-intestinal tract. Hematogeneous disseminated aspergillosis represents another dramatic form of the disease. [less ▲]

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See detailLe lymphome T anaplasique CD30 positif cutané primitif, une affection au pronostic favorable.
Flagothier, Caroline ULg; Quatresooz, Pascale ULg; Franchimont, Claudine ULg et al

in Dermatologie Actualité (2004), 80

Le mycosis fongoïde représente le plus fréquent des lymphomes primitifs de la peau. Le syndrome de Sézary et les lymphomes T anaplasiques sont beaucoup plus rares. Malgré un aspect cytologique très ... [more ▼]

Le mycosis fongoïde représente le plus fréquent des lymphomes primitifs de la peau. Le syndrome de Sézary et les lymphomes T anaplasiques sont beaucoup plus rares. Malgré un aspect cytologique très atypique, le lymphome T anaplasique CD30 positif à localisation cutanée primitive est un lymphome de pronostic favorable. Une concertation et une prise en charge multidisciplinaire sont nécessaires afin d’éviter les écueils d’une thérapeutique résolument trop agressive. [less ▲]

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See detailLa route métastatique du mélanome.
Quatresooz, Pascale ULg; Claessens, Nadine; Arrese Estrada, Jorge ULg et al

in Skin (2004), 7

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See detailImmunohistochemical aid at risk stratification of melanocytic neoplasms.
Quatresooz, Pascale ULg; Arrese Estrada, Jorge ULg; Pierard, Claudine ULg et al

in International Journal of Oncology (2004), 24(1), 211-6

There is increasing awareness of the population about the risk of cutaneous melanoma. In recent years, some improvement was gained in the early recognition of clinical warning signs using dermoscopy. As a ... [more ▼]

There is increasing awareness of the population about the risk of cutaneous melanoma. In recent years, some improvement was gained in the early recognition of clinical warning signs using dermoscopy. As a result, the number of puzzling cases exhibiting limited classical clues for malignancy are submitted to the dermatopathologist. Thus, the risk of microscopic uncertainty or misdiagnosis may be increasing. The aim of the study was to assess retrospectively the contribution of immunohistochemistry in establishing the histological diagnosis of 520 melanocytic neoplasms. According to the disease evolution and the histological presentation, 6 profiles of phenotypical expressions were distinguished. [less ▲]

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See detailProblèmes diagnostiques et thérapeutiques des onychomycoses.
Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Medi-Sphere (2004), 227

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See detailLe cas clinique du mois. Fasciolase cutanée.
Garcia Moreno Rodriguez, Renata ULg; Arrese Estrada, Jorge ULg; Ugarte, G. et al

in Revue Médicale de Liège (2004), 59(10), 552-4

Fascioliasis is an hepato-biliary distomatosis which may exceptionally manifest itself in the skin. We report a case presenting as nodules localized on the trunk. Lesions cleared under praziquantel ... [more ▼]

Fascioliasis is an hepato-biliary distomatosis which may exceptionally manifest itself in the skin. We report a case presenting as nodules localized on the trunk. Lesions cleared under praziquantel treatment. [less ▲]

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See detailLe cas clinique du mois. La syphilis, une MST de retour en nos murs.
Flagothier, Caroline ULg; Arrese Estrada, Jorge ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(7-8), 426-9

Sexually transmitted diseases (STD) show frequent epidemiological changes. We report a case of secondary syphilis diagnosed in a 32-year old woman during post-partum. The disease, although showing a ... [more ▼]

Sexually transmitted diseases (STD) show frequent epidemiological changes. We report a case of secondary syphilis diagnosed in a 32-year old woman during post-partum. The disease, although showing a typical presentation, raises the problem of dating with precision the contamination time. This is of importance for treating the newborn at risk of congenital syphilis. We highlight the constant attention that should be brought to disclose this venereal disease that shows so variable clinical and histological presentations. Syphilis seems on the rise in the Mosan valley and in some cities where prostitution is imported from Eastern Europe and Africa. [less ▲]

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See detailItraconazole corneofungimetry bioassay on Malassezia species.
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Pierard, Claudine ULg

in Mycoses (2004), 47(9-10), 418-21

Yeasts of the genus Malassezia are part of the normal skin biocenosis and are involved in a series of distinct skin disorders and specific dermatomycoses in man and animals. Several species are currently ... [more ▼]

Yeasts of the genus Malassezia are part of the normal skin biocenosis and are involved in a series of distinct skin disorders and specific dermatomycoses in man and animals. Several species are currently distinguished. Their relative in vitro susceptibility to antifungals appears different according to the species and to the nature and route of administration of the drug. Corneofungimetry is an ex vivo bioassay allowing to test the fungal response on human stratum corneum following oral intake of a given antifungal by volunteers. Two series of cyanoacrylate skin surface strippings (CSSS) were harvested from the volar forearm of 30 volunteers before and after a 2-week treatment with itraconazole 200 mg daily. They were coated by olive oil and inoculated with suspensions of seven different Malassezia spp. After a 1-week culture on CSSS, the amount of viable yeasts was assessed using neutral red staining assisted by computerized image analysis. Growth of the seven species was not similar on the CSSS from untreated stratum corneum. The ranking order from the most proliferative to the least was M. restricta, M. sympodialis, M. globosa, M. furfur, M. obtusa, M. slooffiae and M. pachydermatis. Their growth was abated to almost the same level after itraconazole treatment. It is concluded that in vivo treatment with itraconazole is highly active against all Malassezia spp. colonizing the human stratum corneum. [less ▲]

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See detailHistometric assessment of psoriatic plaques treated by vitamin D3 derivatives.
Uhoda, Isabelle; Quatresooz, Pascale ULg; Hermanns-Lê, Trinh ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 366-9

BACKGROUND: Psoriasis is an immunogenetic disorder. Factor XIIIa+ dermal dendrocytes (DD) are part of the pathobiological changes in the plaque type of the disease. OBJECTIVE: The present study aimed at ... [more ▼]

BACKGROUND: Psoriasis is an immunogenetic disorder. Factor XIIIa+ dermal dendrocytes (DD) are part of the pathobiological changes in the plaque type of the disease. OBJECTIVE: The present study aimed at comparing the effect of 3 vitamin D(3) derivatives on the epidermis, microvasculature and DD in psoriasis. METHOD: Twenty men suffering from chronic plaques of psoriasis on the trunk were enrolled in this study. They applied twice a day for 3 weeks calcipotriol, tacalcitol and calcitriol, each to one plaque. Another similar lesion received petrolatum as a placebo treatment. Skin biopsies were taken at entry and at completion of the 3-week treatment phase. Immunohistochemistry was performed using the lectin of Ulex europaeus and an antibody to factor XIIIa. Computerized image analysis served to measure the stratum Malpighii area, the microvasculature area and the DD numerical density in the papillary dermis. RESULTS: At entry in the study, the 4 test sites were indistinguishable with regard to the stratum Malpighii area, the papillary microvasculature area and the papillary DD density. The 3 histometric parameters appeared correlated with each other. At completion of the 3-week treatment phase, the 3 vitamin D derivatives had decreased the size of the stratum Malpighii. In addition, calcitriol had also reduced the DD density in the papillary dermis. No other significant changes were yielded. CONCLUSION: As assessed by histometry, the psoriatic epidermis responded to a short treatment using the 3 vitamin D derivatives. The better result compared to the control site was achieved by calcitriol. DD appeared to be most controlled by the same drug. The microvasculature did not appear to be decreased at the 3-week time point in treatment. [less ▲]

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See detailOnychomycosis under the microscope
PIERARD, Gérald ULg; ARRESE ESTRADA, Jorge ULg; PIERARD-FRANCHIMONT, Claudine ULg et al

Book published by Janssen Pharmaceutica (2003)

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