References of "Angenot, Luc"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailAntioxidant activity of Passiflora edulis and Passiflora alata fruits
Yariwake, J.; Zeraik, M.; Serteyn, Didier ULg et al

in Planta Medica (2010, September), 76(12), 1274-1275

Detailed reference viewed: 68 (6 ULg)
Full Text
Peer Reviewed
See detailBioassay-guided isolation of antiplasmodial Strychnos alkaloids from the stem-bark of Strychnos icaja BAILLON
Tchinda Tiabou, Alembert ULg; Tamze, Victorine; Frederich, Michel ULg et al

in Planta Medica (2010, September), 76(12), 1305

Detailed reference viewed: 63 (1 ULg)
Full Text
Peer Reviewed
See detailAnti-inflammatory potency of the traditionally used antimalarial plant Fagraea fragrans
Jonville, Marie ULg; Baghdikian, Béatrice; Ollivier, Evelyne et al

in Planta Medica (2010, September), 76(12), 1171

Detailed reference viewed: 44 (4 ULg)
See detailPharmacognosie - Volume 2
Angenot, Luc ULg; Tits, Monique ULg; Frederich, Michel ULg

Learning material (2010)

Le volume 2 est consacré aux grands classiques de la pharmacognosie dont ont été isolés de très nombreux principes actifs (souvent des alcaloïdes) qui ont marqué l'histoire de la pharmacie et de la ... [more ▼]

Le volume 2 est consacré aux grands classiques de la pharmacognosie dont ont été isolés de très nombreux principes actifs (souvent des alcaloïdes) qui ont marqué l'histoire de la pharmacie et de la pharmacologie.Les chapitres suivants seront abordés: analgésiques (pavot,opium, colchique...); Solanacées à activité parasympatholytiques ( belladone, stramoine, jusquiames...); dérivés de l'ergot de seigle; médicaments des troubles cérébraux de la sénescence ( ginkgo, amaryllidacées à galanthamine...); drogues alcaloïdiques psychoactives ( coca, éphédra, khat, psilocybes, peyotl, harmel, yagé, iboga...); hallucinogènes non alcaloïdiques ( cannabis, sauge des devins..); poisons agissant sur la neurotransmission :cholinergiques ( jaborandi, éséré...), paralysants neuro-musculaires (curares) et antagonistes de la glycine ( noix-vomique); antiparasitaires (malaria et amibiase): quinquinas, armoises, ipécas; anticancéreux : lignanes ( Podophyllum), diterpènes des ifs (Taxus sp), alcaloïdes indoliques ( Catharanthus roseus, Camptotheca ...), divers ( origine marine, épices...); plantes toxiques de l'environnement ( toxicité par contact ou par ingestion) [less ▲]

Detailed reference viewed: 126 (17 ULg)
See detailPharmacognosie Volume 3
Angenot, Luc ULg; Tits, Monique ULg; Frederich, Michel ULg

Learning material (2010)

Le volume 3 est principalement consacré à la phytothérapie (intérêt et limites) avec des notions concernant aussi bien la médecine traditionnelle que les développements les plus récents ( y compris pour ... [more ▼]

Le volume 3 est principalement consacré à la phytothérapie (intérêt et limites) avec des notions concernant aussi bien la médecine traditionnelle que les développements les plus récents ( y compris pour certains s'appuyant sur des études cliniques) en matière de phytomédicaments. La classification se fait suivant les activités pharmacologiques de ces plantes. Au terme de ce cours, les étudiants doivent pouvoir faire la distinction entre les différentes formes pharmaceutiques à base de produits d'origine naturelle ( poudres, extraits sec et autres), les concentrations en principes actifs et traceurs y étant bien différentes. Les différences entre les médicaments enregistrés et les compléments alimentaires sont également bien mises en évidence car les exigences relatives au contrôle de qualité et à la stabilité des produits finis sont très différentes. A ce sujet l'annexe du volume 3 est consacrée au contrôle de qualité des plantes en insistant sur les méthodes et monographies de la pharmacopée européenne qui joue un rôle essentiel dans ce domaine. [less ▲]

Detailed reference viewed: 97 (11 ULg)
Full Text
Peer Reviewed
See detailMetabolomic analysis of Echinacea spp. by (1)H nuclear magnetic resonance spectrometry and multivariate data analysis technique.
Frederich, Michel ULg; Jansen, C.; De Tullio, Pascal ULg et al

in Phytochemical Analysis (2010), 21(1), 61-65

Introduction - The genus Echinacea (Asteraceae) comprises about 10 species originally distributed in North America. Three species are very well known as they are used worldwide as medicinal plants ... [more ▼]

Introduction - The genus Echinacea (Asteraceae) comprises about 10 species originally distributed in North America. Three species are very well known as they are used worldwide as medicinal plants: Echinacea purpurea, E. pallida, E. angustifolia.Objective - To discriminate between these three Echinacea species and E. simulata by (1)H NMR-based metabolomics.Methodology - (1)H NMR and multivariate analysis techniques were applied to diverse Echinacea plants including roots and aerial parts, authentic plants, commercial plants and commercial dry extracts.Results - Using the (1)H NMR metabolomics, it was possible, without previous evaporation or separation steps, to obtain a metabolic fingerprint to distinguish between species.Conclusion - A clear distinction between the three pharmaceutical species was possible and some useful metabolites were identified. Copyright (c) 2009 John Wiley & Sons, Ltd. [less ▲]

Detailed reference viewed: 98 (13 ULg)
Full Text
Peer Reviewed
See detailMoandaensine, a dimeric indole alkaloid from Strychnos moandaensis (Loganiaceae)
Verpoorte, Robert; Frederich, Michel ULg; Delaude, Clément et al

in Phytochemistry Letters (2010), 3

Moandaensine contains a rare anhydronium base subunit. It presents a moderate antiplasmodial activity with IC values of 11.2 microM and 9.2 microM against , respectively, the chloroquino sensitive FCA 20 ... [more ▼]

Moandaensine contains a rare anhydronium base subunit. It presents a moderate antiplasmodial activity with IC values of 11.2 microM and 9.2 microM against , respectively, the chloroquino sensitive FCA 20 GHA and chloroquino resistant W2 strains of Plasmodium falciparum [less ▲]

Detailed reference viewed: 84 (32 ULg)
Full Text
Peer Reviewed
See detailAntiplasmodial and cytotoxic activities of Rwandan medicinal plants used in the treatment of malaria.
Muganga, R.; Angenot, Luc ULg; Tits, Monique ULg et al

in Journal of Ethnopharmacology (2010), 128

AIM OF THE STUDY: In our study, methanol, dichloromethane and aqueous extracts of 13 Rwandan medicinal plants used in the treatment of malaria were tested for in vitro antiplasmodial activity. MATERIALS ... [more ▼]

AIM OF THE STUDY: In our study, methanol, dichloromethane and aqueous extracts of 13 Rwandan medicinal plants used in the treatment of malaria were tested for in vitro antiplasmodial activity. MATERIALS AND METHODS: The growth inhibition of chloroquine-sensitive Plasmodium falciparum strain (3D7) was evaluated using the measurement of lactate dehydrogenase activity. The active extracts were also tested against the chloroquine-resistant Plasmodium falciparum strain (W2) and for cytotoxicity assay using human normal foetal lung fibroblasts (WI-38). RESULTS: The majority of the plants tested showed an antiplasmodial activity and the best results were observed with dichloromethane leaf and flower extracts of Tithonia diversifolia, leaf extract of Microglossa pyrifolia and root extract of Rumex abyssinicus, methanol leaf extract of Fuerstia africana, root bark extracts of Zanthoxylum chalybeum and methanol bark extract of Terminalia mollis. Those extracts were active (IC(50)<15mug/ml) on both chloroquine-sensitive and resistant strains of Plasmodium falciparum. Zanthoxylum chalybeum, Solanecio mannii and Terminalia mollis presented the best selectivity index. CONCLUSIONS: The traditional use of most of the plant evaluated was confirmed by the antiplasmodial test. This study revealed for the first time the antiplasmodial activity of two plants: Terminalia mollis and Rumex abyssinicus. [less ▲]

Detailed reference viewed: 131 (48 ULg)
Full Text
Peer Reviewed
See detailIsostrychnopentamine, an Indolomonoterpenic Alkaloid from Strychnos usambarensis, with Potential Antitumor Activity against Apoptosis-Resistant Cancer Cells
Balde, El-Hadj Saidou; Mégalizzi, Véronique; Angenot, Luc ULg et al

in International Journal of Oncology (2010), 36

Detailed reference viewed: 60 (19 ULg)
Full Text
Peer Reviewed
See detailEvaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties.
Jansen, Olivia ULg; Angenot, Luc ULg; Tits, Monique ULg et al

in Journal of Ethnopharmacology (2010), 130

AIM OF THE STUDY: The aim of this study was to evaluate the antiplasmodial properties of 13 plants used against malaria in traditional medicine in Burkina Faso. MATERIALS AND METHODS: In vitro ... [more ▼]

AIM OF THE STUDY: The aim of this study was to evaluate the antiplasmodial properties of 13 plants used against malaria in traditional medicine in Burkina Faso. MATERIALS AND METHODS: In vitro antiplasmodial activity of dichloromethane, methanol and aqueous crude extracts obtained from vegetal samples collected in Burkina Faso was first evaluated on the Plasmodium falciparum 3D7 chloroquine-sensitive strain using a colorimetric method. RESULTS: Thirteen extracts obtained from 8 different species were found to exhibit antiplasmodial activity (IC(50)<50mug/ml). Five species demonstrated a moderate activity (15mug/ml<IC(50)<50mug/ml): Boswellia dalzielii (leaves), Waltheria indica (roots and aerial parts), Bergia suffruticosa (whole plant), Vitellaria paradoxa (bark) and Jatropha gossypiifolia (leaves). The best results were obtained with extracts from the Dicoma tomentosa whole plant, from Psorospermum senegalense leaves and from Gardenia sokotensis leaves. These extracts found to display promising antiplasmodial activity, with IC(50) values ranging from 7.0 to 14.0mug/ml. The most active plant extracts were then tested for in vitro activity on the Plasmodium falciparum W2 chloroquine-resistant strain and also for in vitro cytotoxicity on normal human fibroblasts (WI-38) in order to determine the selectivity index. CONCLUSIONS: Dicoma tomentosa (Asteraceae) and Psorospermum senegalense (Clusiaceae) appeared to be the best candidates for further investigation of their antiplasmodial properties, reported for the first time by this study. [less ▲]

Detailed reference viewed: 99 (15 ULg)
Full Text
Peer Reviewed
See detailAlkaloids from Haplophyllum leptomerum
Akhedzhanova, V. I.; Angenot, Luc ULg; Shakirov, R.Sh.

in Chemistry of Natural Compounds (2010), 46(3), 502-503

The plant Haplophyllum leptomerum is indigenous to Uzbekistan and produces alkaloids. This paper describes the isolation and structure determination of 7 alkaloids. Herein we report also the anticancer ... [more ▼]

The plant Haplophyllum leptomerum is indigenous to Uzbekistan and produces alkaloids. This paper describes the isolation and structure determination of 7 alkaloids. Herein we report also the anticancer properties of dictamnine that exhibited moderate activity against two human cancer lines : HeLa and HCT-116. [less ▲]

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailIn vitro and in vivo antimalarial and cytotoxic activity of five plants used in Congolese traditional medicine.
Lusakibanza, M.; Mesia, G.; Tona, G. et al

in Journal of Ethnopharmacology (2010), 129

AIM OF THE STUDY: The in vitro antiplasmodial activity and cytotoxicity of methanolic and dichloromethane extracts from five Congolese plants were evaluated. The plants were selected following an ... [more ▼]

AIM OF THE STUDY: The in vitro antiplasmodial activity and cytotoxicity of methanolic and dichloromethane extracts from five Congolese plants were evaluated. The plants were selected following an ethnobotanical survey conducted in D.R. Congo and focusing on plants used traditionally to treat malaria. The in vivo antimalarial activity of aqueous and methanolic extracts active in vitro was also determined in mice infected by Plasmodium berghei berghei. MATERIALS AND METHODS: The growth inhibition of Plasmodium falciparum strains was evaluated using the measurement of lactate dehydrogenase activity. The extracts (aqueous, CH(3)OH, EtOH and CH(2)Cl(2)) were prepared by maceration and tested in vitro against the 3D7 (chloroquine sensitive) and W2 (chloroquine resistant) strains of Plasmodium falciparum and against the human normal fetal lung fibroblasts WI-38 to determine the selectivity index. Some extracts were also used at the dose of 300mg/kg to evaluate their activity in mice infected since 4 days by Plasmodium berghei. RESULTS: Two plants presented a very high activity (IC(50)<3mug/ml). These plants were Strychnos icaja roots bark (MeOH and CH(2)Cl(2)) and Physalis angulata leaves (MeOH and CH(2)Cl(2)). One plant (Anisopappus chinensis whole plant, MeOH and CH(2)Cl(2)) presented a high activity (IC50<15mug/ml). The extracts of Anisopappus chinensis and Physalis angulata showed also a good inhibition of parasitemia in vivo. Flavonoids, phenolic acids and terpenes were identified in these plants by a general phytochemical screening method. CONCLUSION: Three plants showed a very interesting antiplasmodial activity (Anisopappus chinensis, Physalis angulata and Strychnos icaja) and one of them showed a good selectivity index (>10, Anisopappus chinensis). Anisopappus chinensis and Physalis angulata were also active in vivo. [less ▲]

Detailed reference viewed: 108 (12 ULg)
Full Text
Peer Reviewed
See detailEvaluation des potentialités antiplasmodiales de plantes utilisées en médecine traditionnelle au Burkina Faso
Jansen, Olivia ULg; Nikiéma, Jean-Baptiste; Angenot, Luc ULg et al

Conference (2009, October 07)

Detailed reference viewed: 70 (9 ULg)
Full Text
See detailPlantes médicinales et paludisme
Angenot, Luc ULg

Conference (2009, October 07)

Detailed reference viewed: 19 (3 ULg)
See detailPharmacognosie Volume 1
Angenot, Luc ULg; Tits, Monique ULg

Learning material (2009)

Le volume 1 est principalement consacré à la phytochimie. Le cours est subdivisé suivant les différentes classes chimiques des métabolites primaires et secondaires impliqués soit dans l'activité des ... [more ▼]

Le volume 1 est principalement consacré à la phytochimie. Le cours est subdivisé suivant les différentes classes chimiques des métabolites primaires et secondaires impliqués soit dans l'activité des plantes soit dans leur toxicité ou encore présentant des applications en pharmacotechnie ou dans l'alimentation. La connaissance des structures ( basée sur leur origine biosynthétique) est très importante pour évaluer leur solubilité, leur stabilité et ainsi mieux comprendre les processus d'extraction et les méthodes spécifiques de contrôle ( plantes entières ou pulvérisées, , extraits, huiles essentielles, huiles grasses, exsudats...). dans de nombreux cas, une relation structure-activité pharmacologique ou physiologique est établie. [less ▲]

Detailed reference viewed: 75 (11 ULg)
Full Text
Peer Reviewed
See detailAntisickling properties of divanilloylquinic acids isolated from Fagara zanthoxyloides Lam. (Rutaceae).
Ouattara, Badiore; Jansen, Olivia ULg; Angenot, Luc ULg et al

in Phytomedicine : International Journal of Phytotherapy and Phytopharmacology (2009), 16(2-3), 125-129

Fagara zanthoxyloides Lam. (syn. Zanthoxylum zanthoxyloides) (Rutaceae) is the most cited Fagara species for the treatment and the prevention of sickle cell disease crisis. Sickle cell anemia (SCA) is a ... [more ▼]

Fagara zanthoxyloides Lam. (syn. Zanthoxylum zanthoxyloides) (Rutaceae) is the most cited Fagara species for the treatment and the prevention of sickle cell disease crisis. Sickle cell anemia (SCA) is a public health problem in many countries particularly in Africa. The present study was designed to evaluate the antisickling properties of three isomeric divanilloylquinic acids (3,4-O-divanilloylquinic acid or burkinabin A; 3,5-O-divanilloylquinic acid or burkinabin B and 4,5-O-divanilloylquinic acid or burkinabin C) identified previously by LC/MS/NMR analysis in the root bark of F. zanthoxyloides [Ouattara et al., 2004. LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry 65, 1145-1151]. The three isomers showed interesting antisickling properties which increased from burkinabins A to C. [less ▲]

Detailed reference viewed: 170 (23 ULg)
Full Text
Peer Reviewed
See detailThiaminylated adenine nucleotides — chemical synthesis, structural characterization and natural occurrence
Frederich, Michel ULg; Delvaux, David ULg; Gigliobianco, Tiziana ULg et al

in FEBS Journal (2009), 276(12), 32563268

Thiamine and its three phosphorylated derivatives (mono-, di- and triphosphate) occur naturally in most cells. Recently, we reported the presence of a fourth thiamine derivative, adenosine thiamine ... [more ▼]

Thiamine and its three phosphorylated derivatives (mono-, di- and triphosphate) occur naturally in most cells. Recently, we reported the presence of a fourth thiamine derivative, adenosine thiamine triphosphate (AThTP), produced in E. coli in response to carbon starvation. Here, we show that the chemical synthesis of AThTP leads to another new compound, adenosine thiamine diphosphate (thiaminylated ADP, AThDP), as a side product. The structure of both compounds was confirmed by mass spectrometry and 1H-, 13C- and 31P-NMR and some of their chemical properties were determined. Our results show an upfield shifting of the C-2 proton of the thiazolium ring in adenosine thiamine derivatives compared to the conventional thiamine phosphate derivatives. This modification of the electronic environment of the C-2 proton might be explained by a through-space interaction with the adenosine moiety, suggesting an U-shaped folding of adenosine thiamine derivatives. Such a structure where the C-2 proton is embedded in a closed conformation can be located using molecular modeling as an energy minimum. In E. coli, AThTP may account for 15% of total thiamine under energy stress. It is less abundant in eukaryotic organisms, but is consistently found in mammalian tissues and in some cell lines. Using a HPLC method, we show for the first time that AThDP may also occur in small amounts in E. coli and in vertebrate liver. The discovery of two natural thiamine adenine compounds further highlights the complexity and diversity of thiamine biochemistry, which is not restricted to the cofactor role of thiamine diphosphate. [less ▲]

Detailed reference viewed: 129 (47 ULg)
Full Text
Peer Reviewed
See detailIn Vitro Anticancer Potential of Tree Extracts from the Walloon Region Forest.
Frederich, Michel ULg; Marcowycz, Aline; Cieckiewicz, Ewa ULg et al

in Planta Medica (2009), 75(15), 1634-1637

Forty-eight extracts from 16 common Belgian trees from the Walloon Region forest were evaluated for IN VITRO growth inhibitory activity against the human LoVo colon cancer, PC3 prostate cancer, and U373 ... [more ▼]

Forty-eight extracts from 16 common Belgian trees from the Walloon Region forest were evaluated for IN VITRO growth inhibitory activity against the human LoVo colon cancer, PC3 prostate cancer, and U373 glioblastoma cell lines. Our study was performed with the aim of selecting plant candidates in order to later isolate new anticancer compounds from an easily affordable tree material. Extracts from ALNUS GLUTINOSA (stem bark), CARPINUS BETULUS (leaves and stem bark), CASTANEA SATIVA (stem bark), FAGUS SYLVATICA (leaves), ILEX AQUIFOLIUM (leaves), LARIX DECIDUA (leaves), QUERCUS PETRAEA (stem bark), and QUERCUS ROBUR (leaves) showed for the first time potent IN VITRO growth inhibitory activity and could become easily affordable sources of potential new anticancer agents. Root extracts from ROBINIA PSEUDOACACIA, already known for containing cytotoxic lectins, also showed interesting activity. [less ▲]

Detailed reference viewed: 83 (18 ULg)