Showing results 281 to 300 of 310
   Le Dolichantoside, un alcaloïde nouveau du Strychnos gossweileri; Angenot, Luc  in Planta Medica (1978), 34 This paper reports about the isolation and structure determination of a new indole glucoalkaloid extracted from the roots of Strychnos gossweileri collected in Democratic Republic of Congo (Zaïre) Detailed reference viewed: 10 (0 ULg)Nouveaux alcaloïdes bis-indoliques dans l'écorce des racines du Streychnos variabilisTits, Monique ; Angenot, Luc in Planta Medica (1978), 34 New bis-indole alkaloids (strychnobiline and isostrychnobiline) were extracted from roots of Strychnos variabilis. The plane structures of these alkaloids have been elucidated. Nordihydrotoxiferine is ... [more ▼] New bis-indole alkaloids (strychnobiline and isostrychnobiline) were extracted from roots of Strychnos variabilis. The plane structures of these alkaloids have been elucidated. Nordihydrotoxiferine is also present in this African species of Strychnos. [less ▲] Detailed reference viewed: 10 (2 ULg)Alkaloids from Strychnos usambarensis: revised structure for usambarineAngenot, Luc ; ; Tits, Monique et alin Phytochemistry (1978), 17(9), 1687-1689 Detailed reference viewed: 11 (5 ULg)Structure cristalline et moléculaire d'un nouvel alclaoïde bisindolique: complexe moléculaire 1:2 Strychnofoline-Ethanol; Lamotte-Brasseur, Josette ; et alin Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry (1977), B33 Strychnofoline is a phenolic alkaloid isolated from leaves of Strychnos usambarensis. The crystals of the complex Strychnofoline-Ethanol are monoclinic. the crystal structure has been solvad by direct ... [more ▼] Strychnofoline is a phenolic alkaloid isolated from leaves of Strychnos usambarensis. The crystals of the complex Strychnofoline-Ethanol are monoclinic. the crystal structure has been solvad by direct methods. The configuration determined by biogenetic arguments is 3S?4R?7S?15S?17S?20R. This is the first oxindole alkaloid found in a Strychnos species. [less ▲] Detailed reference viewed: 16 (0 ULg)Nouvelles recherches sur les alcaloïdes des Strychnos africainsAngenot, Luc Report (1976) The author describes recent advances in the chemistry and the pharmacology of African Strychnos. Emphasis is given to the study of leaves of Strychnos usambarensis which contain a series of new molecules ... [more ▼] The author describes recent advances in the chemistry and the pharmacology of African Strychnos. Emphasis is given to the study of leaves of Strychnos usambarensis which contain a series of new molecules (strychnopentamine, strychnofoline, usambaridines ( hydroxyusambarines) A further novel alkaloid (akagerine ) is also identified from the roots of the same species colected in the National Park of Akagera in Rwanda. . [less ▲] Detailed reference viewed: 14 (3 ULg)Convergences chimiques entre les poisons de flèches d'Amérique Latine et ceux d'Afrique Noire; Angenot, Luc in Hommage au Professeur Louis REVOL (1976) Detailed reference viewed: 21 (1 ULg)A propos des transformations de la strychnine et (à propos des principes actifs) des Strychnos curarisants africainsAngenot, Luc ; ; et alin Journal de Pharmacie de Belgique (1976), 31(5), 509-510 Strychnine is unstable under light in chloroformic solution and is partly transformed in pseudostrychnine, genostrychnine (Nb-oxy-strychnine) and chloromethostrychninium (a quaternary derivative). In ... [more ▼] Strychnine is unstable under light in chloroformic solution and is partly transformed in pseudostrychnine, genostrychnine (Nb-oxy-strychnine) and chloromethostrychninium (a quaternary derivative). In other respects the curarizing activity of African Strychnos (e.g. Strychnos usambarensis) is not due to isostrychnine as erroneously written by TURKOVIC (J.Pharm Belg. 1976, 31, 277-286) but to quaternary alkaloids like C-dihydrotoxiferine, C-curarine, afrocurarine and C-calebassine (cf L.ANGENOT et al. Arch. Intern. Pharmacodyn. Ther. 1975, 215, 246-258). [less ▲] Detailed reference viewed: 28 (3 ULg)Structure Cristalline et Moléculaire de la Picrotoxine, C15H16O6.C15H18O7; ; Lamotte, Josette et alin Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry (1976), B32(11), 2987-2993 Picrotoxin is the toxic constituent of Anamirta cocculus fruits. Crystals of picrotoxin are monoclinic and are an addition component of two almost identical molecules :picrotoxinin, C15H16O6, and picrotin ... [more ▼] Picrotoxin is the toxic constituent of Anamirta cocculus fruits. Crystals of picrotoxin are monoclinic and are an addition component of two almost identical molecules :picrotoxinin, C15H16O6, and picrotin, C15H18O7.The structure of each molecule is compared with the crystal structure of alpha1-bromopicrotoxinin. [less ▲] Detailed reference viewed: 39 (6 ULg) Des poisons de flèches aux réactifs pharmacologiques de pointeAngenot, Luc Scientific conference (1976) Detailed reference viewed: 12 (3 ULg)Plantes médicinales cultivées à l'Abbaye d'Orval; ; Angenot, Luc in Jardin des Plantes Médicinales - Abbaye d'Orval (1975) L'ouvrage commente les 88 plantes cultivées dans le jardin médicinal de l'abbaye d'Orval en 1975. il comprend également des monographies détaillées et illustrées sur les plantes suivantes: Angélique ... [more ▼] L'ouvrage commente les 88 plantes cultivées dans le jardin médicinal de l'abbaye d'Orval en 1975. il comprend également des monographies détaillées et illustrées sur les plantes suivantes: Angélique, Aunée, Bardane, Belladone, Bourdaine, Chélidoine, Consoude, Digitale, Fougère Mâle, Guimauve, Hysope, Lavande, Mauve, Mélisse, Menthe poivrée, Origan, Prêle des champs, Primevère, Raifort, Reine des Prés, Romarin, Sauge, Serpolet, Valériane.Un glossaire des termes botaniques, des directives pour la récolte et l'emploi des plantes médicinales sont également présentées ainsi qu'une liste de références bibliographiques. [less ▲] Detailed reference viewed: 120 (2 ULg)La désacétylrétuline extraite du Strychnos variabilisAngenot, Luc ; ; in Phytochemistry (1975), 14 Desacetylretuline has been extracted from the rootbark of Strychnos variabilis collected in Congo (Zaïre). The structure determinatiion was deduced from spectral data (UV,IR, MS, NMR, and CD).It is the ... [more ▼] Desacetylretuline has been extracted from the rootbark of Strychnos variabilis collected in Congo (Zaïre). The structure determinatiion was deduced from spectral data (UV,IR, MS, NMR, and CD).It is the first time that this alkaloid is found in Nature. [less ▲] Detailed reference viewed: 12 (2 ULg)Chemical Structure and Pharmacological (Curarizing) Properties of Various Indole Alkaloids Extracted from an African StrychnosAngenot, Luc ; ; et alin Archives Internationales de Pharmacodynamie et de Thérapie (1975), 215(2), 246-258 The chemical separation and identification of ten alkaloids extracted from the roots of Strychnos usambarensis are described. The elucidation of their structure by means of elementary analysis, IR, UV and ... [more ▼] The chemical separation and identification of ten alkaloids extracted from the roots of Strychnos usambarensis are described. The elucidation of their structure by means of elementary analysis, IR, UV and mass spectrometry allows their classification into bistertiary amines, hybrid and bisquaternary ammonium derivatives. This classification is reflected in the pharmacological properties. One of the tertiary amine alkaloids (usambarensine) presents atropine-like and spasmolytic activities while the bisquaternary ammonium compounds ( dihydrotoxiferine, C-curarine, calebassine and afrocurarine) are competitive neuromuscular blocking agents. [less ▲] Detailed reference viewed: 23 (9 ULg)Structure cristalline et moléculaire d'un nouvel alcaloïde indolique, l'Akagérine: C20H24N2O2; ; Angenot, Luc in Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry (1975), B31(10), 2378-2383 Akagerine is a new alkaloid first isolated by one of us (LA) from roots of Strychnos usambarensis. The crystal structure was determined by direct methods from three-dimensional diffractometer data. The ... [more ▼] Akagerine is a new alkaloid first isolated by one of us (LA) from roots of Strychnos usambarensis. The crystal structure was determined by direct methods from three-dimensional diffractometer data. The crystals are tetragonal. The absolute configuration was not determined. This is the first report of a seven-membered ring with an N1-C17 bond (conventional notation for indole alkaloid). The lone-pair of electrons on N4 is cis with respect to C(3)H and C(15)H.The cohesion of the structure is the result of one hydrogen bond OH...N (2.77O Angstroem) and van der Waals interactions. [less ▲] Detailed reference viewed: 16 (3 ULg)De nouveaux alcaloïdes quaternaires du Strychnos usambarensisAngenot, Luc in Planta Medica (1975), 27(1), 24-30 We have isolated and identified three quaternary monomeric indole alkaloids from barks of Strychnos usambarensis roots. Besides Macusine B, previously found in Strychnos toxifera, two new products are ... [more ▼] We have isolated and identified three quaternary monomeric indole alkaloids from barks of Strychnos usambarensis roots. Besides Macusine B, previously found in Strychnos toxifera, two new products are described: O-methyl-macusine B and O-methyl-dihydro-macusine B. It is not easy to discuss the origin of these last products that could take formation during the extraction. The purification is very laborious because Strychnos usambarensis contains more than sixty alkaloids. [less ▲] Detailed reference viewed: 9 (0 ULg)Détermination de la Structure Cristalline et de la Configuration Absolue du Bromhydrate d'Usambarensine; ; Angenot, Luc in Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry (1975), B31(6), 1571-1575 Usambarensine is a bisindolinic alkaloid found in the bark of Strychnos usambarensis roots. The crystal and molecular structure of usambarensine.2HBr.2H2O has been solved by direct methods thanks to a ... [more ▼] Usambarensine is a bisindolinic alkaloid found in the bark of Strychnos usambarensis roots. The crystal and molecular structure of usambarensine.2HBr.2H2O has been solved by direct methods thanks to a Hilger-Watts four-circle diffractometer. The crystals are monoclinic; refinement of the parameters was carried out with 2459 reflexions. The absolute configuration of the molecule, determined by X-ray anomalous scattering, confirms the 3 alpha cis configuration ( 11alpha cis, IUPAC) assigned earlier by spectral, chromatographic and biogenetic data.This configuration seems dependent on the presence of an ethylidenic chain in the corynane part of the molecule. [less ▲] Detailed reference viewed: 12 (1 ULg)Isolation and structure of akagerine: a new type of indole alkaloidAngenot, Luc ; ; in Tetrahedron Letters (1975), (16), 1357-1358 Detailed reference viewed: 35 (6 ULg)Note sur le Strychnos innocua DELILE ( Loganiaceae)Angenot, Luc ; Wauters, Jean-Noël in Plantes médicinales et phytothérapie (1974), 8(4), 314-317 Strychnos innocua is frequently cited in African traditional medicine. Root bark has been chemically screened.A small amount of alkaloids was detected as well as loganic acid. The plant contains at least ... [more ▼] Strychnos innocua is frequently cited in African traditional medicine. Root bark has been chemically screened.A small amount of alkaloids was detected as well as loganic acid. The plant contains at least two alkaloids that are devoid of an indole skeleton. The authors suggest that they are monoterpenic and not very different from gentianine. However the products would not be artefacts because ammonia was not used for alkalinization before the extraction [less ▲] Detailed reference viewed: 48 (0 ULg)Caractères chimiques et propriétés pharmacologiques de plusieurs alcaloïdes extraits du Strychnos usambarensisDubois, Michel ; ; Angenot, Luc et alin Archives Internationales de Physiologie et de Biochimie (1974), 82 The pharmacological properties of ten tertiary, hybrid and quaternary alkaloids isolated from the barks of Strychnos usambarensis roots have been investigated. Usambarensine, a tertiary bis-indole ... [more ▼] The pharmacological properties of ten tertiary, hybrid and quaternary alkaloids isolated from the barks of Strychnos usambarensis roots have been investigated. Usambarensine, a tertiary bis-indole alkaloid, inhibits the muscarinic effects of acetylcholine. Four ammonium quaternary products (C-dihydrotoxiferine, afrocurarine ( a new compound), C-curarine and C-calebassine are potent curarizing agents. [less ▲] Detailed reference viewed: 60 (0 ULg)Contribution to the study of Strychnos usambarensis GILG, main ingredient of an African curarizing arrow poisonAngenot, Luc in Dissertation Abstracts (1974), 34(11), 338 The thesis is subdivided in four parts and two annexes . the first part concerns the choice of Strychnos usambarensis based on ethnobotanical considerations; the second part is dedicated to the study of ... [more ▼] The thesis is subdivided in four parts and two annexes . the first part concerns the choice of Strychnos usambarensis based on ethnobotanical considerations; the second part is dedicated to the study of arrow poisons in the World and particularly in Africa; the third part describes the isolation of eight indole alkaoids ( 5 new and 3 known ones) and their structure determination thanks to modern spectroscopic methods.The fourth part is applied to the biosynthesis of these alkaloids and to the identification of loganic acid.The first appendix describes the phytochemical screening of 33 Rwandan plants mainly collected in the National Park of Akagera. The second appendix relates pharmacological experiments on crude fractions and some isolated alkaloids. [less ▲] Detailed reference viewed: 12 (4 ULg)Contribution à l'étude du Strychnos usambarensis GILG, principal constituant d'un poison de flèche curarisant africainAngenot, Luc Doctoral thesis (1973) The thesis is subdivided in four parts and two annexes . The first part concerns the choice of Strychnos usambarensis based on ethnobotanical considerations; the second part is dedicated to the study of ... [more ▼] The thesis is subdivided in four parts and two annexes . The first part concerns the choice of Strychnos usambarensis based on ethnobotanical considerations; the second part is dedicated to the study of arrow poisons in the World and particularly in Africa; the third part describes the isolation of eight indole alkaoids ( 5 new and 3 known ones) and their structure determination thanks to modern spectroscopic methods.The fourth part is applied to the biosynthesis of these alkaloids and to the identification of loganic acid.The first appendix describes the phytochemical screening of 33 Rwandan plants mainly collected in the National Park of Akagera. The second appendix relates pharmacological experiments on crude fractions and some isolated alkaloids. [less ▲] Detailed reference viewed: 11 (2 ULg) |
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