References of "Angenot, Luc"
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See detailLes plantes ne végètent pas
Angenot, Luc ULiege; Sutera-Sardo, Anna

Article for general public (1989)

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See detailDosage densitométrique d'hétérosides de la quercetine dans les extraits végétaux
Brasseur, T.; Wauters, J. N.; Angenot, Luc ULiege

in Journal of Chromatography. A (1988), 437(1), 260-4

The assay of quercetine glycosides is easy by TLC and gives better results than those analysed by HPLC in the case of the analysis of a mixture of glucosyl-3 - quercetin and Rhamnoglucosyl-3-quercetin ... [more ▼]

The assay of quercetine glycosides is easy by TLC and gives better results than those analysed by HPLC in the case of the analysis of a mixture of glucosyl-3 - quercetin and Rhamnoglucosyl-3-quercetin because these products are better separated by TLC. The spray reagent for detection was the mixture NP/PEG 400 [less ▲]

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See detailStructure de la panarine Dihydratée, un Nouvel Alcaloïde Extrait d'un Curare Vénézuélien
Dupont, L.; Dideberg, O.; Sbit, M. et al

in Acta Crystallographica Section C-Crystal Structure Communications (1988), C44

The crystal structure of Panarine dihydrate was solved by direct methods. This new alkaloid has a conformation very similar to that of macusine A with a 3-alpha cis configuration. The positive charge on ... [more ▼]

The crystal structure of Panarine dihydrate was solved by direct methods. This new alkaloid has a conformation very similar to that of macusine A with a 3-alpha cis configuration. The positive charge on the quaternary nitrogen coexists with a negative charge on the carboxylate group. Molecules are linked together through van der Waals interactions and five hydrogen bonds involving water molecules. [less ▲]

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See detail10-Hydroxy-Nb-methyl-corynantheol, a new quaternary alkaloid from the stem bark of Strychnos usambarensis
Quetin-Leclercq, Joëlle; Angenot, Luc ULiege

in Phytochemistry (1988), 27(6), 1923-1926

A new quaternary indole alkaloid: 10-hydroxy-Nb-methyl-corynantheol has been isolated from the stem bark of Strychnos usambarensis by High Speed Counter Current Chromatography (HSCCC). Its IUPAC name is 2 ... [more ▼]

A new quaternary indole alkaloid: 10-hydroxy-Nb-methyl-corynantheol has been isolated from the stem bark of Strychnos usambarensis by High Speed Counter Current Chromatography (HSCCC). Its IUPAC name is 2-(2-hydroxyethyl)-3-vinyl-5-methyl-1,2,3,4,6,7,12,12b-octahydro-indolo quinolizinium-9-ol. The structure was established by spectral (UV,IR,EIMS and NMR data) and chemical methods.The stereochemistry was proposedo n the basis of CD curve, NMR studies and biogenetic hypothesis. [less ▲]

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See detailWhy further investigation of Brazilian Strychnos ?
Angenot, Luc ULiege

in Acta Amazonica (1988), 18((1-2)Supl.), 241-258

During the past fifteen years, African Strychnos species have been pharmacologically and chemically screened by some European Universities, sometimes with the collaboration of some African Institutes ... [more ▼]

During the past fifteen years, African Strychnos species have been pharmacologically and chemically screened by some European Universities, sometimes with the collaboration of some African Institutes. Strychnos usambarensis will be discussed here because of interest in it, after the discovery of its use in the preparation of an arrow poison with curarizing activity.The European studies have shown that the African species of Strychnos chemically are very similar to certain South-American species. Indeed, the occurrence in the African species of curarizing quaternary bases, and in the American species of tetanizing bases, such as akagerine, emphasizes the unity of genus Strychnos in terms of its alkaloids.Many biological activities (antimicrobial, hypotensive, spasmolytic,amoebiidal...) have been detected. Finally the antimitotic properties of some alkaloids will be presented. Besides known antitumor drugs e.g. ellipticine and alstonine, African species possess new antimitotic products, e.g. strychnopentamine present in Strychnos usambarensis. Because of these findings, the main reasons why further investigate Brazilian Strychnos species are the lack of knowledge about: -the distribution of the species in the Southern part of the great Amazon basin. According to KRUKOFF, it is possible that new species may be found there.-the distribution of alkaloids in many of known species. Indeed, there is little information on the variation in composition of the alkaloidal mixtures in the different parts of the plants. -the biological activities of alkaloids. in the past, interest has been focused too narrowly on possible curarizing properties. Why should Brazilian species not contain alkaloids with properties similar to those found in the African species? [less ▲]

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See detailIsolation and Purification of Panarine, a Quaternary Alkaloid from a Venezuelian Curare
Quetin-Leclercq, Joëlle; Angenot, Luc ULiege; Dupont, Léon et al

in Phytochemistry (1988), 27(12), 4002-4004

High Speed Counter Current Chromatography (HSCCC) has been used to isolate and purify two quaternary alkaloids from a sample of curare prepared by the Panare Indians of Estado Bolivar, Venezuela. One of ... [more ▼]

High Speed Counter Current Chromatography (HSCCC) has been used to isolate and purify two quaternary alkaloids from a sample of curare prepared by the Panare Indians of Estado Bolivar, Venezuela. One of the compounds is the known base Macusine B. The other one is a new but related base named panarine. Its structure has been established unequivocally by spectral and X-ray cristallographic analysis. [less ▲]

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See detailSix flavonol glycosides from leaves of Strychnos vraiabilis
Brasseur, Thierry; Angenot, Luc ULiege

in Phytochemistry (1988), 27(5), 1487-1490

Four new acylated flavonol glycosides have been identified from leaves of Strychnos variabilis : quercetin 3-(4"-trans-p-coumaroyl) robinobioside and its cis-derivative; kaempferol 3-(4"-trans-p-coumaroyl ... [more ▼]

Four new acylated flavonol glycosides have been identified from leaves of Strychnos variabilis : quercetin 3-(4"-trans-p-coumaroyl) robinobioside and its cis-derivative; kaempferol 3-(4"-trans-p-coumaroyl) robinobioside and its cis derivative. quercetin and kaempferol 3-robinobioside-7-glucosides were also identified. [less ▲]

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See detailAlkaloids of Rauwolfia sellowii from Amazonia
Belem-Pinheiro, Maria-Lucia; Imbiriba da Rocha, Arnaldo; Quetin-Leclercq, Joëlle et al

in Journal de Pharmacie de Belgique (1988), 43(5), 379-381

Reserpiline, sarpagine, lochnerine, harman and beta-yohimbine were the main alkaloids identified in the bark of Rauwolfia sellowii collected in Amazonia. This chemical race could be used for the ... [more ▼]

Reserpiline, sarpagine, lochnerine, harman and beta-yohimbine were the main alkaloids identified in the bark of Rauwolfia sellowii collected in Amazonia. This chemical race could be used for the commercial preparation of reserpiline, which is included in various pharmaceutical proprietary preparations used as antihypertensive. [less ▲]

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See detailStrychnochromine, an unusual C18 indoline alkaloid from Strychnos gossweileri
Angenot, Luc ULiege; Coune, Claude; Quetin-Leclercq, Joëlle et al

in Phytochemistry (1988), 27(2), 595-597

Through a combination of spectroscopic techniques (UV, IR, MS, 1H and 13C NMR) it has been possible to propose a plane structure and the relative configuration of strychnochromine a dextrorotatory ... [more ▼]

Through a combination of spectroscopic techniques (UV, IR, MS, 1H and 13C NMR) it has been possible to propose a plane structure and the relative configuration of strychnochromine a dextrorotatory alkaloid isolated from the root bark of Strychnos gossweileri. [less ▲]

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See detailAlkaloids of Rauwolfia sellowii from Amazonia
Belem-Pinheiro, Maria-Lucia; Imbiriba da Rocha, Arnaldo; Quetin-Leclercq, Joëlle et al

in Fitoterapia (1988), 59(5), 429

Five indole alkaloids ( reserpiline, sarpagine, lochnerine, harman, beat-yohimbine) are identified in the root bark of Rauwolfia sellowii collected for the first time in Amazonian forest (Rio Branco, Acre ... [more ▼]

Five indole alkaloids ( reserpiline, sarpagine, lochnerine, harman, beat-yohimbine) are identified in the root bark of Rauwolfia sellowii collected for the first time in Amazonian forest (Rio Branco, Acre). [less ▲]

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See detailAntimitotic and cytotoxic Activities of Guattegaumerine, a Bisbenzylisoquinoline Alkaloid
Quetin-Leclercq, Joëlle; De Pauw-Gillet, Marie-Claire ULiege; Bassleer, Roger et al

in Planta Medica (1987), 53

Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine ... [more ▼]

Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine exerts a good activity at 5 micrograms/ml on B16 melanoma which is a relatively resistant tumor. It is less active against 2002 cells that are normal human cells. [less ▲]

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See detailAction antiradicalaire de flavonoïdes et d'extraits de Chrysanthellum indicum
Brasseur, Thierry; Angenot, Luc ULiege; Pincemail, Joël ULiege et al

in Plantes médicinales et phytothérapie (1987), 21(2), 131-137

Chrysanthellum indicum DC subsp. americanum ( sold under the name of Chrysanthellum americanum) shows an antiradicalar activity against diphenylpicrylhydrazyl radical (DPPH). the activity seems to be ... [more ▼]

Chrysanthellum indicum DC subsp. americanum ( sold under the name of Chrysanthellum americanum) shows an antiradicalar activity against diphenylpicrylhydrazyl radical (DPPH). the activity seems to be mainly due to unusual flavonoids (e.g. mareine ( a chalcone) and maritimein ( an aurone) .Dilute alcoholic extracts would not be used for extract preparations because the glycosides are rapidly hydrolysed. [less ▲]

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See detailThe structure of isostrychnopentamine, a bisindole monoterpene alkaloid from Strychnos usambarensis
Tavernier, Dirk; Zhang, Weiguo; Angenot, Luc ULiege et al

in Phytochemistry (1987), 26(2), 557-560

The alkaloid isostrychnopentamine has been shown to be epimeric with strychnopentamine at the asymmetric carbon atom of the N-methylpyrrolidin-2-yl group. Its IUPAC name is also given.

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See detailLa troxérutine et la rutine sulfate sodique possèdent-elles encore les propriétés de la rutine?
Brasseur, Thierry; Angenot, Luc ULiege; Pincemail, Joël ULiege et al

in Annales Pharmaceutiques Françaises (1987), 45(4), 329-334

Rutin, sodium rutin sulfate and troxerutin were tested for their antiradicalar, antilipoperoxidant, antioxygen properties and for their activity on in vivo prostaglandin biosynthesis.In each test, rutin ... [more ▼]

Rutin, sodium rutin sulfate and troxerutin were tested for their antiradicalar, antilipoperoxidant, antioxygen properties and for their activity on in vivo prostaglandin biosynthesis.In each test, rutin is more powerful than its derivatives. This fact results mainly on a free orthodiphenolic group ( 3'-4'-hydroxyls on ring B . [less ▲]

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See detailFour acylated flavonol glycosides from leaves of Strychnos variabilis
Brasseur, Thierry; Angenot, Luc ULiege

in Phytochemistry (1987), 26(12), 3331-3334

Four new acylated flavonol glycosides have been isolated and identified from the leaves of Strychnos variabilis: quercetin3-(4"-trans-p-coumaroyl) robinobioside-7-glucoside (variabiloside A) and its cis ... [more ▼]

Four new acylated flavonol glycosides have been isolated and identified from the leaves of Strychnos variabilis: quercetin3-(4"-trans-p-coumaroyl) robinobioside-7-glucoside (variabiloside A) and its cis derivative ( variabiloside B), kaempferol3-(4"-trans-p-coumaroyl)robinobioside-7-glucoside (variabiloside C) and its cis-derivative ( variabiloside D). [less ▲]

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See detailPropriétés antiradicalaires, antilipoperoxydantes et antioxydantes de flavonoïdes
Brasseur, Thierry; Angenot, Luc ULiege; PINCEMAIL, Joël ULiege

Poster (1986, October)

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See detailThe structure of isostrychnopentamine A, a new bisindole monoterpene alkaloid with antimitotic properties
Angenot, Luc ULiege; Tavernier, Dirk; Tits, Monique ULiege et al

Poster (1986, October)

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See detailLe mélange diphénylborate d'aminoéthanol-PEG 400 : un excellent réactif de révélation des flavonoïdes
Brasseur, Thierry; Angenot, Luc ULiege

Poster (1986, July)

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See detailStrychnopentamine
Angenot, Luc ULiege

in Drugs of the Future (1986), 11(1), 42-44

Strychnopentamine is a new alkaloid found in Strychnos usambarensis leaves. It is the first alkaloid with five amines found in a Strychnos species; a methylpyrrolidinic group is joined to a bnzene ring of ... [more ▼]

Strychnopentamine is a new alkaloid found in Strychnos usambarensis leaves. It is the first alkaloid with five amines found in a Strychnos species; a methylpyrrolidinic group is joined to a bnzene ring of the corynane part of the molecule.Antimitotic activity tests were carried out on cultured HW165 hepatoma, B16 melanoma and Ehrlich ascites cells.Strychnopentamine was more active than other indole alkaloids isolated from the same species.Preliminary experiments were then undertaken to search for a possible antitumor activity in animals (Ehrlich ascites tumor cells in mice).At a single dose of 2mg, a very marked regression was obvious but mice showed signs of intoxication. Other experiments must be carried out , in order to establish a more exact structure-activity relationship and to discover less toxic substances. [less ▲]

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See detailFlavonol glycosides from leaves of Strychnos variabilis
Brasseur, Thierry; Angenot, Luc ULiege

in Phytochemistry (1986), 25(2), 563-564

Quercetin 3-O-galactoside, quercetin 3-O-robinobioside and kaempferol 3-O-robinobioside were obtained from the leaves of Strychnos variabilis. These flavonoids were isolated by DCCC (Droplet Counter ... [more ▼]

Quercetin 3-O-galactoside, quercetin 3-O-robinobioside and kaempferol 3-O-robinobioside were obtained from the leaves of Strychnos variabilis. These flavonoids were isolated by DCCC (Droplet Counter Current Chromatography). YThe structures were established by TLC (co-chromatography), UV, NMR ,FAB-MS, hydrolytic and chemical methods. [less ▲]

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