References of "Angenot, Luc"
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See detailPropriétés antiradicalaires, antilipoperoxydantes et antioxydantes de flavonoïdes
Brasseur, Thierry; Angenot, Luc ULg; PINCEMAIL, Joël ULg

Poster (1986, October)

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See detailStrychnopentamine
Angenot, Luc ULg

in Drugs of the Future (1986), 11(1), 42-44

Strychnopentamine is a new alkaloid found in Strychnos usambarensis leaves. It is the first alkaloid with five amines found in a Strychnos species; a methylpyrrolidinic group is joined to a bnzene ring of ... [more ▼]

Strychnopentamine is a new alkaloid found in Strychnos usambarensis leaves. It is the first alkaloid with five amines found in a Strychnos species; a methylpyrrolidinic group is joined to a bnzene ring of the corynane part of the molecule.Antimitotic activity tests were carried out on cultured HW165 hepatoma, B16 melanoma and Ehrlich ascites cells.Strychnopentamine was more active than other indole alkaloids isolated from the same species.Preliminary experiments were then undertaken to search for a possible antitumor activity in animals (Ehrlich ascites tumor cells in mice).At a single dose of 2mg, a very marked regression was obvious but mice showed signs of intoxication. Other experiments must be carried out , in order to establish a more exact structure-activity relationship and to discover less toxic substances. [less ▲]

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See detailScreening of cytotoxic activities of Strychnos alkaloids ( methods and results)
Leclercq, Joëlle; Gillet, Marie-Claire ULg; Bassleer, Roger et al

in Journal of Ethnopharmacology (1986), 15

The potential cytotoxic activities of 46 alkaloids isolated from different Strychnos species were tested on different cancer or normal cells cultured in vitro. The authors use a relatively simple ... [more ▼]

The potential cytotoxic activities of 46 alkaloids isolated from different Strychnos species were tested on different cancer or normal cells cultured in vitro. The authors use a relatively simple microtest which gives good reproducibility. Most of the active compounds belong to the usambarane skeleton but other structure-activity relationships are being discussed. [less ▲]

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See detailUn réactif de choix pour la révélation des flavonoïdes: le mélange Diphénylborate d'aminoéthanol-PEG 400
Brasseur, Thierry; Angenot, Luc ULg

in Bulletin de Liaison- Groupe Polyphenols (1986)

Par les fluorescences et colorations variées qu'il donne, ce réactif est très utile au chercheur et comme il est également capable de révéler d'autres composés tels des depsides, des acides phénols etc ... [more ▼]

Par les fluorescences et colorations variées qu'il donne, ce réactif est très utile au chercheur et comme il est également capable de révéler d'autres composés tels des depsides, des acides phénols etc...il constitue pour le pharmacognoste et le pharmacien d'industrie un réactif de choix pour l'identification des drogues végétales et la recherche de leurs falsifications. [less ▲]

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See detailLe mélange diphénylborate d'aminoéthanol-PEG 400: Un intéressant réactif de révélation des flavonoïdes
Brasseur, Thierry; Angenot, Luc ULg

in Journal of Chromatography (1986), 351

NP/PEG reagent is very useful for the chromatographic identification of various classes of flavonoids.

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See detailPropriétés antiradicalaires, antilipoperoxydantes et antioxydantes de flavonoïdes
Brasseur, Thierry; Angenot, Luc ULg; Pincemail, Joël ULg et al

in Bulletin de Liaison- Groupe Polyphenols (1986)

Nos résultats indiquent que le terme antioxydant ne peut plus être employé au sens large et montrent le rôle considérable que jouent les fonctions phénoliques des cycles B et C et la double liaison du ... [more ▼]

Nos résultats indiquent que le terme antioxydant ne peut plus être employé au sens large et montrent le rôle considérable que jouent les fonctions phénoliques des cycles B et C et la double liaison du cycle C dans l'activité des flavonoïdes. [less ▲]

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See detailFlavonol glycosides from leaves of Strychnos variabilis
Brasseur, Thierry; Angenot, Luc ULg

in Phytochemistry (1986), 25(2), 563-564

Quercetin 3-O-galactoside, quercetin 3-O-robinobioside and kaempferol 3-O-robinobioside were obtained from the leaves of Strychnos variabilis. These flavonoids were isolated by DCCC (Droplet Counter ... [more ▼]

Quercetin 3-O-galactoside, quercetin 3-O-robinobioside and kaempferol 3-O-robinobioside were obtained from the leaves of Strychnos variabilis. These flavonoids were isolated by DCCC (Droplet Counter Current Chromatography). YThe structures were established by TLC (co-chromatography), UV, NMR ,FAB-MS, hydrolytic and chemical methods. [less ▲]

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See detailMédecine, Thérapeutiques et Plantes médicinales
Lecomte, Jean; Angenot, Luc ULg

in Journal de Pharmacie de Belgique (1986), 41(Supplement), 3-10

In the Western World, as many people became concerned at the potency and side effects of new drugs, there is an increasing interest in the alternative systems, including phytotherapy, and as the ... [more ▼]

In the Western World, as many people became concerned at the potency and side effects of new drugs, there is an increasing interest in the alternative systems, including phytotherapy, and as the pharmacist must be the best qualified to advise on, and supply all drugs (e.g. herbal products) we give below our scientific opinion about the real position of plants in modern therapy. Records extant from Ancien egypt, Assyria, Greece and roma show that the use of plants for medicinal purposes exetnd back to our earliest recorded history. during the course of history, the cure of disease and the use of medicinal plants has been much influenced by religious practice and the exercise of magical rites. Thus the philosophy of the "Doctrine of Signatures" introduced by Paracelsus in the sixteenth century had considerable sway for four centuries and was not completely abandoned until the modern era of phytochemistry and pharmacology gave an alternative system for the rationalization of the use of plants in medicine. However, for most of herbal remedies, it is not still possible to demonstrate or evaluate their pharmacological activity, and the situation is complicated by the frequent use of a number of drugs in combination, the supposed active constituents of which have not been elucidated. Arising from this, orthodox medicine came to disregard sub "polypharmaceutical" preparations and concentrated research on the isolation of natural individual components having, for example, demonstrable anticancer, hypotensive ; antiplasmodial or antimicrobial properties. [less ▲]

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See detailStrychnozairine, an indole alkaloid from Strychnos variabilis
Tits, Monique ULg; Tavernier, Dirk; Angenot, Luc ULg

in Phytochemistry (1985), 34(1), 205-207

Through a combination of spectroscopic techniques (UV,CD,IR,MS and NMR) it has been possible to show that strychnozairine, an alkaloid isolated from the root bark of Strychnos variabilis, is N&-acetyl-16 ... [more ▼]

Through a combination of spectroscopic techniques (UV,CD,IR,MS and NMR) it has been possible to show that strychnozairine, an alkaloid isolated from the root bark of Strychnos variabilis, is N&-acetyl-16-R-formyl-19-oxo-20,21-didehydrostrychnane. [less ▲]

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See detailEffets de la dihydroflavopéreirine et de la sempervirine (alacaloïdes dérivés de la beta-carboline) sur des cellules cancéreuses en culture
Bassleer, Roger; Clermont, D.; Marnette, J. M. et al

in Annales Pharmaceutiques Françaises (1985), 43(1), 83-88

The cellular effects of dihydroflavopereirine and sempervirine ( two alkaloids isolated from Loganiaceae) are analysed by cytological methods in experimental tumours cultivated in vitro ( B16 mouse ... [more ▼]

The cellular effects of dihydroflavopereirine and sempervirine ( two alkaloids isolated from Loganiaceae) are analysed by cytological methods in experimental tumours cultivated in vitro ( B16 mouse melanoma cells, mouse Ehrlich tumour cells ELT). Under some experimental conditions, a certain degree of antimitotic activity is demonstrated and related to the molecular structure. [less ▲]

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See detailDescription, identification et utilisation du Yumel ( Ecorce de Guatteria gaumeri GREENMAN)
Leclercq, Joëlle; Dehaussy, Hélène; Goblet, Marie-Claire et al

in Journal de Pharmacie de Belgique (1985), 40(4), 251-256

The authors give a survey of the known data and biological studies about the bark and the tincture of Guatteria gaumeri (Yumel). They describe not only methods of micrographic and chromatographic ... [more ▼]

The authors give a survey of the known data and biological studies about the bark and the tincture of Guatteria gaumeri (Yumel). They describe not only methods of micrographic and chromatographic identification of the drug, but also a quantitative determination of the two main constituents: alpha-asarone ( propenylbenzene derivative) and guattegaumerine ( bisbenzylisoquinoleine alkaloid). [less ▲]

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See detailDolichantoside, Main Alkaloid from Stem Bark of Strychnos Tricalysioides
Leclercq, Joëlle; Angenot, Luc ULg

in Planta Medica (1984), 50(5), 457-8

The bark of Strychnos tricalysioides from Cameroon has been studied. The main alkaloid (present in a minute amount) was identified to dolichantoside (TLC, UV, IR and CD) and compared to a reference ... [more ▼]

The bark of Strychnos tricalysioides from Cameroon has been studied. The main alkaloid (present in a minute amount) was identified to dolichantoside (TLC, UV, IR and CD) and compared to a reference compound previously isolated in our laboratory from Strychnos gossweileri root bark. [less ▲]

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See detailThe structure of strychnozairine, a new indole alkaloid from Strychnos variabilis
Tits, Monique ULg; Tavernier, Dirk; Angenot, Luc ULg

Poster (1984, July)

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See detailAbout Drosera peltata and the standardization of the sundew's tincture ( Tinctura Droserae)
Leclercq, Joëlle; Angenot, Luc ULg

Poster (1984, July)

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See detailIsolement et détermination de Structure de l' Afrocurarine
Caprasse, M.; Angenot, Luc ULg; Tavernier, D. et al

in Planta Medica (1984), 50(2), 131-133

The structure and the stereochemistry of afrocurarine (a new unsymmetrical bisindole alkaloid) previously isolated from S. USAMBARENSIS Gilg. are established especially from (1)H-NMR spectroscopic data ... [more ▼]

The structure and the stereochemistry of afrocurarine (a new unsymmetrical bisindole alkaloid) previously isolated from S. USAMBARENSIS Gilg. are established especially from (1)H-NMR spectroscopic data. The separation of quaternary alkaloids has always been very tedious. Ion-pair reversed-phase column chromatography applied to the purification of afrocurarine is proved very useful and seems to be a suitable technique in quaternary alkaloid research. [less ▲]

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See detailLa strychnoxanthine, un alcaloide monoterpénique d'un nouveau type isolé à partir du Strychnos gossweileri
Coune, C.; Tavernier, D.; Caprasse, M. et al

in Planta Medica (1984), 50(1), 93-95

Strychnoxanthine, an anhydronium base, was isolated from root barks of STRYCHNOS GOSSWEILERI, a few years ago. The structure of this new indole alkaloid is now established by spectral analysis, especially ... [more ▼]

Strychnoxanthine, an anhydronium base, was isolated from root barks of STRYCHNOS GOSSWEILERI, a few years ago. The structure of this new indole alkaloid is now established by spectral analysis, especially by (1)H NMR at 360 MHz. [less ▲]

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See detailIsolement de Nb-méthylantirhine, malindine et isomalindine à partir du Strychnos Usambarensis
Caprasse, M.; Tavernier, D.; Anteunis, M. J. et al

in Planta Medica (1984), 50(1), 27-30

Three quaternary alkaloids have been isolated from root barks of STRYCHNOS USAMBARENSIS Gilg from Rwanda: malindine, isomalindine and Nb-methyl-antirhine. The structure elucidation and the stereochemistry ... [more ▼]

Three quaternary alkaloids have been isolated from root barks of STRYCHNOS USAMBARENSIS Gilg from Rwanda: malindine, isomalindine and Nb-methyl-antirhine. The structure elucidation and the stereochemistry of the new isomalindine has been proposed based on its spectral data and their comparison with those of malindine, its isomer. [less ▲]

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