References of "Angenot, Luc"
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See detailOptimization of a high performance thin layer chromatography method to quantify solanines in potatoes
Bodart, Patricia; Hubert, Philippe ULiege; Angenot, Luc ULiege et al

Conference (1999, May)

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See detailGuiaflavine, un nouvel alcaloïde quaternaire bisindolique isolé à partir de l'écorce de tige du Strychnos guianensis
Penelle, Jacques; Tits, Monique ULiege; Christen, Philippe et al

Poster (1999, May)

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See detailQuatre alcaloïdes à noyau bèta-carboline isolés des écorces de tronc du Strychnos mellodora
Brandt, Viviane; Tits, Monique ULiege; Geerlings, A et al

Poster (1999, May)

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See detailGuiaflavine, a new bisindole quaternary alkaloid from the stem bark of Strychnos guianensis
Penelle, Jacques; Tits, Monique ULiege; Christen, Philippe et al

Conference (1999, May)

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See detailBeta-Carboline Glucoalkaloids from Strychnos mellodora
Brandt, Viviane; Tits, Monique ULiege; Geerlings, A. et al

Conference (1999, May)

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See detail10'-Hydroxyusambarensine, a New Antimalarial Bisindole Alkaloid from the Roots of Strychnos Usambarensis
Frederich, Michel ULiege; Tits, Monique ULiege; Hayette, Marie-Pierre ULiege et al

in Journal of Natural Products (1999), 62(4), 619-21

Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods ... [more ▼]

Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods. Compound 1 was moderately active against two strains of Plasmodium falciparum in vitro. [less ▲]

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See detailThe plant alkaloid usambarensine intercalates into DNA and induces apoptosis in human HL60 leukemia cells
Dassonneville, L.; Wattez, N.; Mahieu, C. et al

in Anticancer Research (1999), 19(6B), 5245-5250

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See detailQuantitative analysis of -solanine and -chaconine in potatoes by high performance thin layer chromatography
Bodart, P.; Hubert, Philippe ULiege; Kabengera, Ch. et al

Conference (1999)

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See detailLysosomal phospholipases inhibition by emetine, strychnopentamine and usambarensine
Quetin-Leclercq, Joelle; Schomer, G; Van Bambeke, F et al

Poster (1999)

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See detailbeta-carboline glucoalkaloids from Strychnos mellodora
Brandt, V.; Tits, Monique ULiege; Geerlings, A. et al

in Phytochemistry (1999), 51(8), 1171-1176

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See detailOptimization of a high performance thin layer chromatography method to quantify solanines in patatoes
Bodart, P.; Hubert, Philippe ULiege; Angenot, Luc ULiege et al

in Journal de Pharmacie de Belgique (1999), 54

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See detailStimulation of topoisomerase II-mediated DNA cleavage by three DNA-intercalating plant alkaloids: cryptolepine, matadine, and serpentine.
Dassonneville, L.; Bonjean, K.; De Pauw-Gillet, Marie-Claire ULiege et al

in Biochemistry (1999), 38(24), 7719-26

Cryptolepine, matadine, and serpentine are three indoloquinoline alkaloids isolated from the roots of African plants: Cryptolepis sanguinolenta, Strychnos gossweileri, and Rauwolfia serpentina ... [more ▼]

Cryptolepine, matadine, and serpentine are three indoloquinoline alkaloids isolated from the roots of African plants: Cryptolepis sanguinolenta, Strychnos gossweileri, and Rauwolfia serpentina, respectively. For a long time, these alkaloids have been used in African folk medicine in the form of plant extracts for the treatment of multiple diseases, in particular as antimalarial drugs. To date, the molecular basis for their diverse biological effects remains poorly understood. To elucidate their mechanism of action, we studied their interaction with DNA and their effects on topoisomerase II. The strength and mode of binding to DNA of the three alkaloids were investigated by spectroscopy. The alkaloids bind tightly to DNA and behave as typical intercalating agents. All three compounds stabilize the topoisomerase II-DNA covalent complex and stimulate the cutting of DNA by topoisomerase II. The poisoning effect is more pronounced with cryptolepine than with matadine and serpentine, but none of the drugs exhibit a preference for cutting at a specific base. Cryptolepine which binds 10-fold more tightly to DNA than the two related alkaloids proves to be much more cytotoxic toward B16 melanoma cells than matadine and serpentine. The cellular consequences of the inhibition of topoisomerase II by cryptolepine were investigated using the HL60 leukemia cell line. The flow cytometry analysis shows that the drug alters the cell cycle distribution, but no sign of drug-induced apoptosis was detected when evaluating the internucleosomal fragmentation of DNA in cells. Cryptolepine-treated cells probably die via necrosis rather than via apoptosis. The results provide evidence that DNA and topoisomerase II are the primary targets of cryptolepine, matadine, and serpentine. [less ▲]

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See detailAnti-inflammatory properties of capsular polymers from blue-green algae.
Garbacki, Nancy ULiege; Gloaguen, Vincent; Damas, Jacques ULiege et al

Conference (1999)

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See detailPlantes toxiques et champignons vénéneux de notre environnement
Angenot, Luc ULiege

Scientific conference (1998, June 13)

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See detailStrychnochrysine, a New Bisindole Alkaloid from the Roots of Strychnos Nux-Vomica
Biala, Rose Gadi; Tits, Monique ULiege; Penelle, Jacques et al

in Journal of Natural Products (1998), 61(1), 139-41

The reinvestigation of Strychnos nux-vomica resulted in the isolation of a colored monoquaternary bisindole alkaloid from the roots. The structure of this new orange substance, strychnochrysine (1), was ... [more ▼]

The reinvestigation of Strychnos nux-vomica resulted in the isolation of a colored monoquaternary bisindole alkaloid from the roots. The structure of this new orange substance, strychnochrysine (1), was defined by detailed spectroscopic methods. [less ▲]

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See detailCharacterization of Adulteration of "Espinheira Santa" ( Maytenus ilicifolia and Maytenus aquifolium, Celastraceae) Hydroalcoholic Extracts with Sorocea bomplandii ( Moraceae) by High-Performance Thin Layer Chromatography
Vilegas, Janete H.Y.; Lanças, Fernando M.; Wauters, Jean-Noël ULiege et al

in Phytochemical Analysis (1998), 9

A HPTLC procedure for the characterization of adulteration of " espinheira santa ( Maytenus sp) with Sorocea bomplandii by monitoring their flavonoid content with the aid of diphenylboric reagent, is ... [more ▼]

A HPTLC procedure for the characterization of adulteration of " espinheira santa ( Maytenus sp) with Sorocea bomplandii by monitoring their flavonoid content with the aid of diphenylboric reagent, is presented. HPTLC data showed the predominance of higly glycosated quercetin and kaempferol derivatives. The derivated flavonoids were shown to be best markers for distinguishing between authentic and adulterated drug samples, with several advantages over triterpene analysis [less ▲]

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