References of "Adam, Stéphane"
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See detailDiagnostic précoce de la maladie d'Alzheimer : la tâche RI-48
Adam, Stéphane ULg

Scientific conference (2005, September 07)

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See detailAnxiety and depression, attention, and executive functions in hypothyroidism
Constant, Eric; Adam, Stéphane ULg; Seron, Xavier et al

in Journal of the International Neuropsychological Society (2005), 11(5), 535-544

Background: Divergences in cognitive disturbances in hypothyroidism reported in the literature are a result of a methodological bias. Methods: By using a precise methodology, we examined attention and ... [more ▼]

Background: Divergences in cognitive disturbances in hypothyroidism reported in the literature are a result of a methodological bias. Methods: By using a precise methodology, we examined attention and executive functions in hypothyroidism, verified the presence of anxiety and depressive symptoms in hypothyroidism, and examined the possible link between these symptoms and the cognitive disturbances (searching for attentional bias for words with a negative emotional valence). We administered a battery of cognitive tests to 23 participants who had undergone thyroidectomy for thyroid carcinoma: for the first time in an euthyroid state, then 3 weeks later (still in the euthyroid state) to assess the test/retest effect, and finally 4 weeks later in an hypothyroid state. We compared their performance with that of a group of 26 control participants who were also administered the same cognitive tests, also 3 times. Results: In hypothyroidism, the thyroid participants were more anxious and depressed than the controls and presented attentional and executive disturbances that reflected general slowing and difficulties in using their capacities of inhibition. However, they did not exhibit an attentional bias for words with a negative emotional valence. Conclusions: Contrary to what was expected, symptoms of anxiety and not symptoms of depression interfered with the cognitive performance of participants in hypothyroidism. [less ▲]

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See detailFurther exploration of controlled and automatic memory processes in early Alzheimer's disease
Adam, Stéphane ULg; Van der Linden, Martial ULg; Collette, Fabienne ULg et al

in Neuropsychology (2005), 19(4), 420-427

The authors' aim in this study was to explore automatic and controlled processes in Alzheimer's disease (AD) by using a variant of the word-stem completion task that applies the process-dissociation ... [more ▼]

The authors' aim in this study was to explore automatic and controlled processes in Alzheimer's disease (AD) by using a variant of the word-stem completion task that applies the process-dissociation procedure. Several methodological precautions were taken in order to limit problems observed in previous studies (e.g., poor task sensitivity, ceiling and/or floor effects, no control over comprehension of instructions). Our results (a) confirmed the marked deterioration in controlled processes and (b) showed that when psychometric constraints were limited, automatic memory processes were preserved in AD. These data are in line with those from more global studies in suggesting that AD is characterized by an early deterioration in controlled processes and an initial preservation of automatic processes. [less ▲]

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See detailMaladie d'Alzheimer: Prise en charge cognitive des troubles de la mémoire
Adam, Stéphane ULg

Conference (2005, June 09)

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See detailAcquisition of face-name associations in Early Alzheimer's Disease: A Comparison of Different Methods
Bier, Nathalie; Gagnon, Lise; Van der Linden, Martial et al

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2005, June), 1(1), 60

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See detailSubacute effects of sertraline on attentional and executive functions in depression
Constant, Eric; Adam, Stéphane ULg; Gillain, B. et al

Poster (2005, May 31)

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See detailRôle des erreurs et de la mémoire implicite dans l’efficacité de méthodes d’apprentissage appliquées dans la DTA en début d’évolution
Bier, Nathalie; Gagnon, Lise; Van der Linden, Martial et al

Poster (2005, May 12)

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See detailApport de la neuropsychologie dans le cadre du diagnostic précoce de la maladie d'Alzheimer
Adam, Stéphane ULg

Conference given outside the academic context (2005)

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See detailNouveaux apprentissages dans la DTA en début d’évolution : rôles des erreurs et de la mémoire implicite
Bier, Nathalie; Gagnon, Lise; Van der Linden, Martial et al

Conference (2005, May 05)

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See detailControlled and automatic uses of memory in depressed patients: effect of retention interval lengths
Jermann, Françoise; Van der Linden, Martial ULg; Adam, Stéphane ULg et al

in Behaviour Research and Therapy (2005), 43(5), 681-690

The present study examines controlled and automatic uses of memory in clinically depressed patients by applying the Process Dissociation Procedure developed by Jacoby (1991) to a stem completion memory ... [more ▼]

The present study examines controlled and automatic uses of memory in clinically depressed patients by applying the Process Dissociation Procedure developed by Jacoby (1991) to a stem completion memory task with short and long retention intervals. The results show that the contribution of controlled processes is lower in depressed patients than in controls, especially for the longest retention interval, whereas the contribution of automatic processes is equivalent in both groups and unaffected by the length of the retention interval. These findings are discussed in a cognitive control framework. (c) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailApprentissage d’associations noms-visages dans la DTA en début d’évolution : comparaison de méthodes d’apprentissage
Bier, Nathalie; Gagnon, Lise; Van der Linden, Martial et al

Poster (2005, March 30)

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See detailCerebral metabolic correlates of four dementia scales in Alzheimer's disease
Salmon, Eric ULg; Lespagnard, Solange ULg; Marique, Patricia et al

in Journal of Neurology (2005), 252(3), 283-290

Different scales can be used to evaluate dementia severity in Alzheimers disease (AD). They do assess different cognitive or functional abilities, but their global scores are frequently in mutual ... [more ▼]

Different scales can be used to evaluate dementia severity in Alzheimers disease (AD). They do assess different cognitive or functional abilities, but their global scores are frequently in mutual correlation. Functional imaging provides an objective method for the staging of dementia severity. Positron emission tomography was used to assess the relationship between brain metabolism and four dementia scales that reflect a patients global cognitive abilities (mini mental state), caregivers evaluation of cognitive impairment (newly designed scale), daily living functioning (instrumental activities of daily living) and global dementia (clinical dementia rating). We wondered whether different clinical dementia scales would be related to severity of metabolic impairment in the same brain regions, and might reflect impairment of common cognitive processes. 225 patients with probable AD were recruited in a prospective multicentre European study. All clinical scales were related to brain metabolism in associative temporal, parietal or frontal areas. A factorial analysis demonstrated that all scales could be classified in a single factor. That factor was highly correlated to decrease of cerebral activity in bilateral parietal and temporal cortices, precuneus, and left middle frontal gyrus. This finding suggests that global scores for all scales provided similar information on the neural substrate of dementia severity. Capitalizing on the neuroimaging literature, dementia severity reflected by reduced metabolism in posterior and frontal associative areas in AD might be related to a decrease of controlled processes. [less ▲]

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See detailMemory evaluation with a new cued recall test in patients with mild cognitive impairment and Alzheimer's disease
Ivanoiu, Adrian; Adam, Stéphane ULg; Van der Linden, Martial ULg et al

in Journal of Neurology (2005), 252(1), 47-55

Free delayed recall is considered the memory measure with the greatest sensitivity for the early diagnosis of dementia. However, its specificity for dementia could be lower, as deficits other than those ... [more ▼]

Free delayed recall is considered the memory measure with the greatest sensitivity for the early diagnosis of dementia. However, its specificity for dementia could be lower, as deficits other than those of pure memory might account for poor performance in this difficult and effortful task. Cued recall is supposed to allow a better distinction between poor memory due to concurrent factors and impairments related to the neurodegenerative process. The available cued recall tests suffer from a ceiling effect. This is a prospective, longitudinal study aiming to assess the utility of a new memory test based on cued recall that avoids the ceiling effect in the early diagnosis of Alzheimer's disease (AD). Twenty-five patients with mild cognitive impairment (MCI), 22 probable AD patients ( NINCDS-ADRDA) at a mild stage, 22 elderly patients with subjective memory complaints (SMC) and 38 normal age-matched controls took part in the study. The patients underwent a thorough cognitive evaluation and the recommended screening procedure for the diagnosis of dementia. All patients were re-examined 12 - 18 months later. A newly devised delayed cued recall test using semantic cues ( The RI48 Test) was compared with three established memory tests: the Ten Word-List Recall from CERAD, the "Doors" and the "Shapes" Tests from "The Doors and People Test Battery". Forty-four % of the MCI patients fulfilled criteria for probable AD at follow-up. The RI48 Test classified correctly 88% of the MCI and SMC participants and was the best predictor of the status of MCI and mild AD as well as the outcome of the MCI patients. Poor visual memory was the second best predictor of those MCI patients who evolved to AD. A cued recall test which avoids the ceiling effect is at least as good as the delayed free recall tests in the early detection of AD. [less ▲]

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See detailEXploration des processus inhibiteurs dans le vieillissement normal et la maladie d'Alzheimer
Collette, Fabienne ULg; Adam, Stéphane ULg; Hogge, Michaël et al

in Revue Neurologique (2005), 161(12), 467

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See detailTwo Aspects of Impaired Consciousness in Alzheimer's Disease
Salmon, Eric ULg; Ruby, Perrine; Perani, Daniela et al

in Progress in Brain Research (2005), 150(Boundaries of Consciousness: Neurobiology and Neuropathology), 287-98

Alzheimer's disease (AD) is a degenerative dementia characterized by different aspects of impaired consciousness. For example, there is a deficit of controlled processes that require conscious processing ... [more ▼]

Alzheimer's disease (AD) is a degenerative dementia characterized by different aspects of impaired consciousness. For example, there is a deficit of controlled processes that require conscious processing of information. Such an impairment is indexed by decreased performances at controlled cognitive tasks, and it is related to reduced brain metabolic activity in a network of frontal, posterior associative, and limbic regions. Another aspect of impaired consciousness is that AD patients show variable levels of anosognosia concerning their cognitive deficits. A discrepancy score between patient's and caregiver's assessment of cognitive functions is one of the most frequently used measures of anosognosia. A high discrepancy score has been related to impaired activity in the superior frontal sulcus and the parietal cortex in AD. Anosognosia for cognitive deficits in AD could be partly explained by impaired metabolism in parts of networks subserving self-referential processes (e.g., the superior frontal sulcus) and perspective-taking (e.g., the temporoparietal junction). We hypothesize that these patients are impaired in the ability to see themselves with a third-person perspective (i.e., being able to see themselves as other people see them). [less ▲]

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See detailEffects of sertraline on depressive symptoms and attentional and executive functions in major depression
Constant, Eric; Adam, Stéphane ULg; Gillain, B. et al

in Depression and Anxiety (2005), 21(2), 78-89

Reports on the severity and reversibility of cognitive disturbances in major depression in the literature diverge due to methodological biases. The present study, using a precise methodology, examined ... [more ▼]

Reports on the severity and reversibility of cognitive disturbances in major depression in the literature diverge due to methodological biases. The present study, using a precise methodology, examined attention and executive functions in 20 relatively young, depressed patients presenting a first or second episode of unipolar major depression without psychotic or melancholic characteristics and all being treated with the same psychopharmacological treatment (sertraline) to investigate the changes in potential attentional and executive loss during a subacute period of treatment of 7 weeks. We compared their performance with a group of 26 control subjects who were administered the same cognitive tests. This study confirmed psychomotor slowing associated with attentional and executive disturbance in adults with major depression. Conscious attentional interference for words with a negative emotional valence also was shown. After the first weeks of treatment, the effect of the antidepressant treatment with sertraline was accompanied by a beneficial effect on psychomotor slowing on attentional and executive functions. © 2005 Wiley-Liss, Inc. [less ▲]

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See detailInvestigation of automatic memory during general anesthesia for elective surgery using the process dissociation procedure
Willems, Sylvie ULg; Iselin-Chaves, Irène A.; Jermann, Françoise J. et al

in Anesthesiology (2005), 103

Background: This prospective study evaluated memory function during general anesthesia for elective surgery and its relation to depth of hypnotic state. The authors also compared memory function in ... [more ▼]

Background: This prospective study evaluated memory function during general anesthesia for elective surgery and its relation to depth of hypnotic state. The authors also compared memory function in anesthetized and nonanesthetized subjects. Methods: Words were played for 70 min via headphones to 48 patients (aged 18–70 yr) after induction of general anesthesia for elective surgery. Patients were unpremedicated, and the anesthetic regimen was free. The Bispectral Index (BIS) was recorded throughout the study. Within 36 h after the word presentation, memory was assessed using an auditory word stem completion test with inclusion and exclusion instructions. Memory performance and the contribution of explicit and implicit memory were calculated using the process dissociation procedure. The authors applied the same memory task to a control group of nonanesthetized subjects. Results: Forty-seven patients received isoflurane, and one patient received propofol for anesthesia. The mean ( SD) BIS was 49 9. There was evidence of memory for words presented during light (BIS 61–80) and adequate anesthesia (BIS 41–60) but not during deep anesthesia (BIS 21–40). The process dissociation procedure showed a significant implicit memory contribution but not reliable explicit memory contribution (mean explicit memory scores 0.05 0.14, 0.04 0.09, and 0.05 0.14; mean automatic influence scores 0.14 0.12, 0.17 0.17, and 0.18 0.21 at BIS 21–40, 41–60, and 61–80, respectively). Compared with anesthetized patients, the memory performance of nonanesthetized subjects was better, with a higher contribution by explicit memory and a comparable contribution by implicit memory. Conclusion: During general anesthesia for elective surgery, implicit memory persists even in adequate hypnotic states, to a comparable degree as in nonanesthetized subjects. [less ▲]

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See detailLa maladie d'Alzheimer
Adam, Stéphane ULg

Conference given outside the academic context (2004)

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See detailEvaluation de l’effet d’oubli induit à la récupération dans le vieillissement normal
Hogge, Michaël; Adam, Stéphane ULg; Collette, Fabienne ULg

Poster (2004, December 04)

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