References of "ANSSEAU, Marc"
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See detailFacteurs genetiques de l'alcoolo-dependance Revue des principales donnees de la litterature.
Pinto, Emmanuel ULg; Ansseau, Marc ULg

in Encéphale (L') (2009), 35(5), 461-9

INTRODUCTION: Alcohol dependence is a complex and multifactorial disease resulting both from neurobiological mechanisms and environmental factors. It is frequently associated with comorbid psychiatric ... [more ▼]

INTRODUCTION: Alcohol dependence is a complex and multifactorial disease resulting both from neurobiological mechanisms and environmental factors. It is frequently associated with comorbid psychiatric disorders or with specific personality or behavioral features. Although action can be taken on the environment in order to decrease the risk of the illness, current methods used to prevent or to treat this pathology show moderate efficacy: problematic consumption of ethanol in the general population as well as relapse rates under treatment in dependent patients remain indeed very high. LITERATURE FINDINGS: It is therefore of major importance to broaden our knowledge of alcohol dependence and its comorbidities so as to improve both their prevention and treatment. In this perspective, recent progress in the field of neurosciences may contribute to achieve this goal. Precisely, genetics is a promising way benefiting from many advances in genetic epidemiology, cellular and molecular biology, neuroimaging and pharmacology. In parallel with a better understanding of the neurobiology of addictions and associated behaviors, these techniques led to the identification of brain mechanisms in which a genetic variation may influence the individual vulnerability towards alcohol dependence. Moreover, there is growing evidence that alcoholism results from the interaction of genetic and environmental factors influencing both its expression and its course. Given the fact that alcohol-dependence seems highly heritable (50 to 60% of the variance in both men and women), this review assesses the role of some of the genomic regions linked with the disease, as well as the principal variants of candidate genes identified as specifically involved in the predisposition. Polymorphisms of genes influencing alcohol metabolism, GABAergic, dopaminergic and serotonergic neurotransmission seem, indeed, at stake in the development of alcohol-dependence and its related features such as personality, behavior, impulse control or craving. In the future, a better characterization of the links between genotypes and phenotypes will probably increase our ability to treat alcoholic patients. [less ▲]

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See detailNeurobiological bases of suicidality in major depression
Desseilles, Martin ULg; Scwartz, Sophie; Dang Vu, Thanh et al

in World Journal of Biological Psychiatry (2009), 9(Suppl. 1),

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See detailAbnormal neural filtering of irrelevant visual information in depression
Desseilles, Martin ULg; Balteau, Evelyne ULg; Sterpenich, Virginie et al

in NeuroImage (2009), 45(Suppl. 1),

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See detailObjective: remission of depression in primary care The Oreon Study.
Ansseau, Marc ULg; Demyttenaere, Koen; Heyrman, Jan et al

in European Neuropsychopharmacology (2009), 19(3), 169-76

OBJECTIVE: Treatment of depression should result in the absence of symptoms, i.e. remission, in order to restore the functional status of the patient and reduce the risk for relapse. The study assessed ... [more ▼]

OBJECTIVE: Treatment of depression should result in the absence of symptoms, i.e. remission, in order to restore the functional status of the patient and reduce the risk for relapse. The study assessed the current remission rates in primary care and determined the influencing factors. METHODS: 10 consecutive depressive patients treated by antidepressants for at least 3 months and not more than 12 months were screened by each investigator. Remission rates were defined using the Hamilton-Depression scale 7 items (score of 3 or less) as well as the Carroll self rating scale (score of 7 or less). In addition, patients completed the Sheehan Disability Scale (SDS). Initial severity of depression, type of treatment and socio-economic factors were collected. RESULTS: 292 general practitioners screened a total of 2630 patients. Results indicated low remission rates: 28.3% according to the clinician and 17.1% according to the patient. Absence of remission was associated with higher impairment in work, social and family life. The most frequently reported residual symptoms in nonremitters were general somatic symptoms (92%), depressed mood (92%), psychic anxiety (91%) and impaired work and activities (89%). No differences were observed in remission rates between men and women. Remission rates were significantly lower in patients living alone as compared to those living in couple or family (25.1% vs 30.2%, p=0.03), in patients with lower education (21.3% vs 32.3%, p<0.001), in patients speaking French as compared to Dutch (24.0% vs 34.0% p<0.001), and unemployed patients compared to patients having an occupation (17.1% vs 39.0%, p<0.001). Higher initial severity and number of previous episodes decreased remission rates (p<0.001). CONCLUSION: This study shows low remission rates in depressed patients treated in general practice. The absence of remission is associated with impairment in work, social and family life. Special attention should be given to identify patients who do not reach remission. [less ▲]

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See detailOxytocin: From milk ejection to maladaptation in stress response and psychiatric disorders. A psychoneuroendocrine perspective.
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg; Geenen, Vincent ULg et al

in Annales d'Endocrinologie (2009), 70(6), 449-54

Oxytocin (OT) is implicated in stress reduction as well as in social behavior. It inhibits the stress-induced activity of the hypothalamic-pituitary adrenal axis responsiveness. OT is involved in social ... [more ▼]

Oxytocin (OT) is implicated in stress reduction as well as in social behavior. It inhibits the stress-induced activity of the hypothalamic-pituitary adrenal axis responsiveness. OT is involved in social affiliation, sexual and maternal-infant binding, anxiety, mood, feeding control and memory. Several lines of evidence suggest a role of OT in psychiatric disorders. Various psychiatric disorders are strongly influenced by social variables, such as panic attacks, depression and early childhood autism, and seem to exhibit a particularly close connection with the brain dynamics that underlie social emotions. This paper proposes an overview of OT in psychiatric disorders through the links with the stress response and prosocial behavior. [less ▲]

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See detailL'hypnose dans la prise en charge des douleurs chroniques
Zelinka, V.; Faymonville, Marie-Elisabeth ULg; Pitchot, William ULg et al

in Acta Psychiatrica Belgica (2009), 109(3), 21-28

OUR REVIEW OF THE LITERATURE SUGGESTSTHAT HYPNOSIS IS AN USEFUL OPTION lN THE MANAGEMENT OF CHRONIC PAIN.THE EXPLANATIONS FOR ITS EFFECTIVENESS RELIE MAINLY ON THE FINDINGS OF FUNCTIONAL NEUROIMAGING ... [more ▼]

OUR REVIEW OF THE LITERATURE SUGGESTSTHAT HYPNOSIS IS AN USEFUL OPTION lN THE MANAGEMENT OF CHRONIC PAIN.THE EXPLANATIONS FOR ITS EFFECTIVENESS RELIE MAINLY ON THE FINDINGS OF FUNCTIONAL NEUROIMAGING, CLINICAL STUDIES AND EMPIRICAL OBSERVATIONS. THESE DATA SHOWTHAT THROUGH THE DIVERSITY OF ITS EFFECTS, HYPNOSIS CAN MODULATE THE BIO-PSYCHO-SOCIAL DIMENSIONS OF CHRONIC PAIN. THE CHOICE OF THIS THERAPEUTIC TECHNIQUE SHOULD BE GUIDED BY THE ESTIMATE OF ITS USEFULNESS. THE EFFICACY IS ASSESSED ON AN INDIVIDUAL BASIS, TAKING INTO ACCOUNT THE BENEFITS AND LIMITATIONS OF HYPNOSIS FOR EACH PATIENT. [less ▲]

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See detailDependance au zolpidem et crise d'epilepsie.
Pitchot, William ULg; Ansseau, Marc ULg

in Revue Médicale de Liège (2009), 64(7-8), 407-8

Zolpidem is an imidazopiridine with hypnotic properties. Compared to benzodiazepines, zolpidem has a mechanism of action that is thought to reduce the risk of dependence or abuse. However, in the past 10 ... [more ▼]

Zolpidem is an imidazopiridine with hypnotic properties. Compared to benzodiazepines, zolpidem has a mechanism of action that is thought to reduce the risk of dependence or abuse. However, in the past 10 years, several cases of zolpidem abuse, dependence and withdrawal reactions have been described in the litterature. Here, we describe a case of dependence and withdrawal seizure. [less ▲]

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See detailThe TaqI A DRD2 polymorphism in type II alcohol dependence: a marker of age at onset or of a familial disease?
Pinto, Emmanuel ULg; Reggers, Jean ULg; Gorwood, Philip et al

in Alcohol (2009), 43(4), 271-5

Cloninger's type II is a severe, early-onset, male-limited, and genetically influenced, impulsive form of alcoholism. Significant association has been reported between the A1 allele of the D2 dopamine ... [more ▼]

Cloninger's type II is a severe, early-onset, male-limited, and genetically influenced, impulsive form of alcoholism. Significant association has been reported between the A1 allele of the D2 dopamine receptor (DRD2) gene, substance misuse and personality traits of impulsivity and novelty seeking. We assessed the association between the TaqI A DRD2 gene polymorphism with Cloninger's typology and family history of alcohol abuse, which is thought to be more frequent in type II alcoholics. Fifty-one male alcohol-dependent patients were discriminated between type I and type II according to age at onset of alcohol-related problems and interviewed about family history of alcoholism. The associations between DRD2 (A1 or A2 alleles), family history, and typology were assessed by Pearson's chi-square test. Although typology was not associated with the studied polymorphism, a higher rate of general family history of alcohol abuse was still observed in type II patients (chi(2)(1)=4.53; P=.033). Furthermore, the A1 allele of the DRD2 was significantly associated with paternal history of alcoholism (chi(2)(1)=4.66; P=.031) and male, first-degree, collateral history of alcoholism (chi(2)(1)=4.40; P=.036). Age at onset of alcohol-related problems as main discriminator between type I and type II alcohol dependence does not seem to be associated by the TaqI A DRD2 polymorphism. However, the A1 allele of the DRD2 may be a marker of male familial alcoholism, which has been associated with type II alcohol dependence. [less ▲]

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See detailLe cerveau dans tous ses etats.
Moonen, Gustave ULg; Ansseau, Marc ULg; Scheen, André ULg

in Revue Médicale de Liège (2008), 63(5-6), 229-30

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See detailContingent negative variation abnormalities in posttraumatic stress disorder
Papart, Patrick ULg; Ansseau, Marc ULg; Bartholomé, F.

in European Neuropsychopharmacology (2008), 18(Suppl 4), 481-482

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See detailL'électroconvulsivothérapie en 2008.
Servais, Sophie ULg; Ansseau, Marc ULg; Mikolajczak, Gladys ULg et al

in Revue Médicale de Liège (2008), 63

L’électroconvulsivothérapie (anciennement dénommée sismothérapie, électronarcose ou électrochoc) est une technique thérapeutique utilisée dans certaines affections psychiatriques. Elle consiste en la ... [more ▼]

L’électroconvulsivothérapie (anciennement dénommée sismothérapie, électronarcose ou électrochoc) est une technique thérapeutique utilisée dans certaines affections psychiatriques. Elle consiste en la réalisation d’une crise convulsive généralisée induite par le passage d’un courant électrique transcrânien. S’il est vrai que cette méthode continue de stigmatiser l’imaginaire collectif en suscitant effroi et méfiance (modèle de barbarie thérapeutique pour certains, traitement obsolète pour d’autres), elle se révèle, au contraire, être un traitement souvent très efficace, dans certains cas irremplaçable, et dans l’ensemble très bien toléré. Ainsi, ces dernières années ont vu un regain d’intérêt pour l’ECT. Elle constitue, aujourd’hui, la plus ancienne des somathérapies psychiatriques toujours en vigueur. [less ▲]

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See detailDépression et neuroplasticité.
Pitchot, William ULg; Polis, Marie-Hélène ULg; Belachew, Shibeshih ULg et al

in Revue Médicale de Liège (2008), 63

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See detailEditorial. Le cerveau dans tous ses états.
Moonen, Gustave ULg; Ansseau, Marc ULg; Scheen, André ULg

in Revue Médicale de Liège (2008), 63

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See detailShock-like sensations associated with duloxetine discontinuation.
Pitchot, William ULg; Ansseau, Marc ULg

in Annals of Clinical psychiatry : Official Journal of the American Academy of Clinical Psychiatrists (2008), 20(3), 175

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See detailThe short allele of the serotonin transporter promoter polymorphism influences relapse in alcohol dependence.
Pinto, Emmanuel ULg; Reggers, Jean ULg; Gorwood, Philip et al

in Alcohol & Alcoholism (2008), 43

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See detailVasopressin-neurophysin and DST in major depression : Relationship with suicidal behavior.
Pitchot, William ULg; Scantamburlo, Gabrielle ULg; Pinto, Emmanuel ULg et al

in Journal of Psychiatric Research (2008), 42

The purpose of the present study was to assess if AVP-neurophysin is associated with hypercortisolemia and suicidal behaviour in depressed patients. The study included 28 patients subgrouped into suicide ... [more ▼]

The purpose of the present study was to assess if AVP-neurophysin is associated with hypercortisolemia and suicidal behaviour in depressed patients. The study included 28 patients subgrouped into suicide attempters (n=13) and nonattempters (n=15). We assessed basal AVP-neurophysins concentrations and post-dexamethasone (DST) cortisol levels. Concentrations of AVP-neurophysins did not differ between DST suppressors and nonsuppressors: 0.29+/-0.13ng/ml vs 0.36+/-0.21ng/ml, (F=1.1, df=1, 27, p=0.30). Suicide attempters did not differ from nonattempters for AVP-neurophysins levels. Our results fail to support a role of AVP in the early cortisol escape. [less ▲]

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See detailLa marche du sujet fibromyalgique et d’un sujet dépressif est-elle différenciable ? Exploration de deux affections « voisines » à partir d’un accéléromètre tri-axial.
Maquet, Didier ULg; Jaspar, J.; Lecart, Marie-Paule ULg et al

in Revue du Rhumatisme (2008), 75

Objectif : Analyser la marche de populations souffrant d’affections présentant certaines similitudes en termes de symptomatologie (fatigue, stress, anxiété, ralentissement psychomoteur, …) et pour ... [more ▼]

Objectif : Analyser la marche de populations souffrant d’affections présentant certaines similitudes en termes de symptomatologie (fatigue, stress, anxiété, ralentissement psychomoteur, …) et pour lesquelles le diagnostic différentiel apparaît parfois malaisé. Patients et méthodes : Cette étude inclut 32 sujets fibromyalgiques (46  10 ans), 20 sujets hospitalisés pour un état dépressif (49  14 ans) et 20 sujets volontaires contrôles (49  16 ans). L’analyse tri-dimensionnelle de la marche est réalisée à partir d'un système ambulatoire d'accélérométrie triaxial (Locometrix® Centaure Metrix, France) et d'une ligne de chronométrage. Le sujet marche à sa vitesse de confort, équipé de l'accéléromètre fixé à l'aide d'une ceinture élastique. L'épreuve, composée de 6 trajets rectilignes de 40 mètres, permet de suivre le profil des paramètres analysés tout au long de la distance totale parcourue (240 mètres). Les paramètres analysés sont : la vitesse de marche, la fréquence de pas, la longueur de pas, la symétrie et la régularité des pas, la puissance mécanique suivant les axes antéro-postérieur, crânio-caudal et médio-latéral, le coût énergétique. Résultats : La marche de la population fibromyalgique présente diverses altérations significatives non seulement en comparaison de la population contrôle mais aussi de la population dépressive. Nous observons chez le fibromyalgique une réduction significative (p < 0,05) de la vitesse de marche, de la longueur de pas, des activités suivant les axes antéro-postérieur et crânio-caudal. En outre, cette population présente une marche moins régulière (p < 0,05) alors que le coût énergétique de la marche est diminué (p < 0,05). Les paramètres de marche enregistrés au sein de la population dépressive apparaissent intermédiaires entre sujets contrôles et fibromyalgiques. Cependant, aucune modification significative ne s’observe entre populations contrôle et dépressive. Des travaux ultérieurs tenteront en outre de mettre en relation l’altération des paramètres de marche avec le degré d’anxiété et de dépression objectivé. Discussion : Bien que l’on évoque régulièrement un ralentissement fonctionnel chez les sujets souffrant de ces 2 affections « voisines », ce travail démontre que la marche d’un sujet dépressif et d’un sujet fibromyalgique semble différenciable. Ce dernier adopte une marche plus lente, moins régulière et visant à une « économie » d’énergie comme l’atteste le coût énergétique et les activités suivant les 3 axes. Conclusion : Cette épreuve pourrait constituer un outil original dans la caractérisation d’une population pathologique et le suivi longitudinal d’un patient. [less ▲]

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