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See detailREVISED EU-CRITERIA FOR APPLYING BIOANALYTICAL METHODS FOR SCREENING OF FEED AND FOOD FOR DIOXINS AND DIOXIN-LIKE PCBS.
Hoogenboom, LAP; Hadrich, Johan; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2010), 72

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See detailDietary intake of PCDD/Fs and dioxin-like PCBs of the Belgian Population
Windal, Isabelle; Vandevijvere, S.; Maleki, M. et al

in Chemosphere (2010), 79

The World Health Organization recommends assessing human exposure to contaminants on a regular basis. In order to assess the current dietary exposure of the Belgian adult population to PCDD/Fs and dioxin ... [more ▼]

The World Health Organization recommends assessing human exposure to contaminants on a regular basis. In order to assess the current dietary exposure of the Belgian adult population to PCDD/Fs and dioxin-like PCBs and to update exposure estimates of 2000–2001, a total diet study was designed. The mean dietary intake of PCDD/Fs and dioxin-like PCBs in the Belgian adult population in 2008 was estimated to be 0.72 pg TEQ kgbw-1 d-1 (middle bound concentrations, TEF of 1998) based on occurrence data of 2008 and national food consumption data of 2004. This value is clearly below the Tolerable Weekly Intake (TWI) of 14 pg TEQ kgbw-1 week-1 set by the Scientific Committee on Food of the European Commission and below the provisional tolerable monthly intake of 70 pg TEQ kgbw-1 month-1 set by the Joint FAO/WHO Expert Committee on Food Additives. Considering the cumulative distribution, the intake was less than 1 pg TEQ kgbw-1 d-1 for more than 80% of the population, and less than 2 pg TEQ kgbw-1 d-1 for the entire population. When using the 2005 TEF instead of the 1998 TEF, the mean dietary intake in the Belgian adult population was estimated to be 0.61 pg TEQ kgbw-1 d-1. [less ▲]

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See detailAssessment of the chemical contamination in home-produced eggs in Belgium: General overview of the CONTEGG study
Van Overmeire, Ilse; Pussemier, Luc; Wageneers, Nadia et al

in Science of the Total Environment (2009), 407(15), 4403-4410

This overview paper describes a study conducted for the Belgian Federal Public Service of Health, Food Chain Safety and Environment during 2006–2007. Home-produced eggs from Belgian private owners of hens ... [more ▼]

This overview paper describes a study conducted for the Belgian Federal Public Service of Health, Food Chain Safety and Environment during 2006–2007. Home-produced eggs from Belgian private owners of hens were included in a large study aiming to determine concentration levels of various environmental contaminants. Bymeans of the analyses of soil samples and of kitchen waste samples, obtained from the same locations, an investigation towards the possible sources of contaminants was possible. Eggs, soils, faeces and kitchen waste samples were checked for the presence of dioxins, PCBs (including dioxin-like PCBs), organochlorine pesticides, trace elements, PAHs, brominated flame retardants and mycotoxins. The study design, sampling methodology and primary conclusions of the study are given. It was found that in some cases dioxin-like compounds were present at levels that are of concern for the health of the egg consumers. Therefore, measures to limit their contamination in eggs, produced by hens of private owners, were proposed and deserve further attentio [less ▲]

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See detailValidation and interpretation of CALUX as a tool for the estimation of dioxin-like activity in marine biological matrixes.
Windal, Isabelle; Van Wouwe, Nathalie; Eppe, Gauthier ULg et al

in Environmental Science & Technology (2005), 39(6), 1741-1748

Among the different analytical tools proposed as an alternative to the very expensive gas chromatography high-resolution mass spectrometry (GC-HRMS) analyses of polychlorodibenzo-p-dioxin and ... [more ▼]

Among the different analytical tools proposed as an alternative to the very expensive gas chromatography high-resolution mass spectrometry (GC-HRMS) analyses of polychlorodibenzo-p-dioxin and polychlorodibenzofurans, Chemically Activated LUciferase gene eXpression (CALUX) in vitro cell bioassay is very promising. It allows the analyses of a high number of samples since it is relatively fast, inexpensive, and sensitive. However, this technique is not yet widely applied for screening or environmental monitoring. The main reasons are probably the lack of validation and the difficulty in interpreting the global biological response of the bioassay. In this paper, the strict quality control criteria set up for the validation of CALUX are described. The validation has shown good repeatability (relative standard deviation (RSD) = 9%) and good within-lab reproducibility (RSD = 15%) of the results. The quantification limit, in the conditions applied in this paper, is 1.25 pg CALUX-TEQ/g fat. Comparison of CALUX and GC-HRMS analysis was made for various marine matrixes (fishes, mussels, starfishes, sea birds, and marine mammals). Good correlations are usually observed, but there are systematic differences between the results. Attempts are made to identify the origin of the discrepancy between the two methods. [less ▲]

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See detailComparison of the rat and mouse cell lines commercially available for CALUX bioassays
Goeyens, Leo; Windal, Isabelle; Scippo, Marie-Louise ULg et al

in Organohalogen compounds (2004), 66

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See detailDIOXIN BODY BURDEN AMONG BLOOD DONORS BEFORE AND AFTER THE BELGIAN DIOXIN/PCB INCIDENT
Debacker, Noemi; Sasse, André; Van Wouwe, Nathalie et al

in Organohalogen Compounds (2004)

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See detailApplication of the CALUX bioassay for epidemiological study: analyses of Belgian human plasma
Van Wouwe, Nathalie; Debacker, Noemi; Sasse, André et al

in Organohalogen Compounds (2004)

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See detailValidation and discussion of CALUX analysis for marine samples
Windal, Isabelle; Van Wouwe, Nathalie; Carbonnelle, Sophie et al

in Organohalogen Compounds (2003)

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See detailSelective adsorption of dioxins and PCBs from marine oils on activated carbon
De Meulenaer, Bruno; Maes, Jeroen; Van Heerswynghels, Peter et al

in Organohalogen Compounds (2003)

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See detailAnalysis of PCDD/Fs in human blood plasma using CALUX bioassay and GC-HRMS: a comparison
Van Wouwe, Nathalie; Eppe, Gauthier ULg; Xhrouet, Céline ULg et al

in Organohalogen Compounds (2003)

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