  Moandaensine, a dimeric indole alkaloid from Strychnos moandaensis (Loganiaceae); Frederich, Michel  ; et alin Phytochemistry Letters (2010), 3 Moandaensine contains a rare anhydronium base subunit. It presents a moderate antiplasmodial activity with IC values of 11.2 microM and 9.2 microM against , respectively, the chloroquino sensitive FCA 20 ... [more ▼] Moandaensine contains a rare anhydronium base subunit. It presents a moderate antiplasmodial activity with IC values of 11.2 microM and 9.2 microM against , respectively, the chloroquino sensitive FCA 20 GHA and chloroquino resistant W2 strains of Plasmodium falciparum [less ▲] Detailed reference viewed: 66 (31 ULg) Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leavesFrederich, Michel ; ; et alin Planta Medica (2004), 70(1), 72-76 A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D ... [more ▼] A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base proper-ties and exhibited strong antiplasmodial properties (IC50 less than 1 muM). [less ▲] Detailed reference viewed: 37 (10 ULg) |
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