References of "Lybaert, P"
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See detailTransforming Growth Factor Beta 1 Activation, Storage, and Signaling Pathways in Idiopathic Pulmonary Fibrosis in Dogs.
Krafft, Emilie; Lybaert, P.; Roels, Elodie ULg et al

in Journal of Veterinary Internal Medicine (2014), 28

BACKGROUND: The pathogenesis of idiopathic pulmonary fibrosis (IPF) in dogs is poorly understood. In human, transforming growth factor beta1 (TGF-beta1) is considered central in the pathogenesis ... [more ▼]

BACKGROUND: The pathogenesis of idiopathic pulmonary fibrosis (IPF) in dogs is poorly understood. In human, transforming growth factor beta1 (TGF-beta1) is considered central in the pathogenesis. OBJECTIVES: To investigate TGF-beta1 pathway in IPF. ANIMALS: Lung tissues from 12 affected and 11 control dogs. Serum from 16 affected West Highland white Terriers (WHWTs) and healthy dogs from predisposed (13 WHWTs, 12 Scottish Terriers and 13 Bichons Frise) and nonpredisposed breeds (10 Whippets, 10 Belgian shepherds, 8 Labradors). METHODS: In this prospective study, immunohistochemistry was used to evaluate expression and localization of TGF-beta1 protein and proteins involved in TGF-beta1 signaling (TGF-beta receptor type I and phospho-Smad2/3). Pulmonary expression of TGF-beta1 and molecules involved in its storage (latent TGF-beta binding proteins [LTBP] 1, 2, and 4), activation (alphanubeta6 and alphanubeta8 integrins, thrombospondin-1) and signal inhibition (Smad 7) was analyzed by quantitative reverse transcriptase PCR. Circulating TGF-beta1 concentration was measured by ELISA. RESULTS: In IPF, high level of TGF-beta1 protein was found in areas of fibrosis, epithelial cells had strong expression of TGF-beta receptor type 1 and phospho-Smad2/3, gene expression was decreased for LTBP 4 (P = .009) and beta8 integrin (P < .001) and increased for thrombospondin-1 (P = .016); no difference was seen for Smad7, LTBP1 and 2. Serum TGF-beta1 concentration was higher in predisposed compared with nonpredisposed breeds (P < .0001). CONCLUSIONS AND CLINICAL IMPORTANCE: This study identified an enhanced TGF-beta1 signaling activity in IPF. TGF-beta1 storage and activation proteins with altered expression represent potential therapeutic targets. Higher circulating TGF-beta1 concentration in predisposed breeds might partly explain their susceptibility for IPF [less ▲]

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See detailImmunohistochemical transforming growth factor Beta1 and its activation, storage and signalling pathways in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Laurila, HP; Rajamäki, MM et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailTransforming growth factor beta 1 and its activation, storage and signalling pathways in canine idiopathic pulmonary fibrosis.
Krafft, Emilie ULg; Heikkilä, H.P.; Rajamäki, M.M. et al

Scientific conference (2013, July)

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See detailEtude d'un critère complémentaire pour l'évaluation de la surchauffe des bâtiments dans le cadre de l'étude du confort en régime été (deuxième partie)
Dupont, Géraldine ULg; Hauglustaine, Jean-Marie ULg; Nourricier, S. et al

Report (2008)

The Walloon region entrusted to FPMs and ULg, the following study: - Study bibliography (research of work carried out in the field and the effective methods or recommendations in the adjoining countries ... [more ▼]

The Walloon region entrusted to FPMs and ULg, the following study: - Study bibliography (research of work carried out in the field and the effective methods or recommendations in the adjoining countries); - Application or development of the identified methods of calculating; - Comparison between the methods evaluation simplified and the results provided by a detailed software; - Proposal for a criterion or recommendations compared to the methods evaluated at the preceding points (advantages and disadvantages of the approaches taking into account the particular climate of Belgium). This criterion will be required by exploiting the currently available methods of evaluation of overheating. [less ▲]

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See detailPerformance énergétique des bâtiments résidentiels en Wallonie : Etude relative à la détermination de la consommation d'énergie primaire de référence
Hauglustaine, Jean-Marie ULg; Dupont, Géraldine ULg; Di Pietrantonio, M. et al

Report (2006)

Objects of the study: - To constitute a sample of representative buildings (individual residences and collectives), a fortnight; - To formulate Eréf, with for objective preserving ethics, varying the ... [more ▼]

Objects of the study: - To constitute a sample of representative buildings (individual residences and collectives), a fortnight; - To formulate Eréf, with for objective preserving ethics, varying the assumptions on the basis of a situation corresponding to the actual position (K55) worms of the more severe requirements; - To calculate and compare the level of consumption of primary energy € according to the Flemish approach and the proposal of FPMs; - To highlight the interests for the various actors from one or the other formulation. [less ▲]

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