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See detailDetermination of uncertainty in a liquid chromatographic method for erythromycin from Interlaboratory study results
Dehouck, Pieter; Vander Heyden, Yvan; Smeyers-Verbecke, Johanna et al

Conference (2003, May)

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See detailDetermination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample
Dehouck, Pieter; Vander Heyden, Yvan; Smeyers-Verbeke, Johanna et al

in Analytica Chimica Acta (2003), 481

The correct interpretation of a measurement result requires knowledge about its uncertainty. Depending on the conditions under which the analyst is operating, different operational definitions of ... [more ▼]

The correct interpretation of a measurement result requires knowledge about its uncertainty. Depending on the conditions under which the analyst is operating, different operational definitions of uncertainty have been proposed. They include: within-laboratory uncertainty, reproducibility uncertainty, bias-included uncertainty and absolute uncertainty. Here we consider the evaluation of the reproducibility uncertainty derived from the results obtained in an inter-laboratory experiment. Nine laboratories participated in an inter-laboratory study for the analysis of phenoxymethylpenicillin. The analyses consisted of a Karl–Fischer water determination, an acid–base titration to assay phenoxymethylpenicillin and a liquid chromatography (LC) method to determine 4-hydroxyphenoxymethylpenicillin and other impurities. The experimental set-up allowed to obtain for each determination s2 r and s2L as estimates of the repeatability variance (σ2r ) and the between-laboratory variance (σ2L), respectively. The reproducibility uncertainties for the different assays were then derived from these estimates. [less ▲]

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See detailInterlaboratory study of a liquid chromatography method for erythromycin: determination of uncertainty.
Dehouck, P.; Vander Heyden, Y.; Smeyers-Verbeke, J. et al

in Journal of Chromatography. A (2003), 1010(1), 63-74

Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been ... [more ▼]

Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been developed. It makes use of an Astec C18 polymeric column. After validation in one laboratory, the method was now validated in an interlaboratory study. Validation studies are commonly used to test the fitness of the analytical method prior to its use for routine quality testing. The data derived in the interlaboratory study can be used to make an uncertainty statement as well. The relationship between validation and uncertainty statement is not clear for many analysts and there is a need to show how the existing data, derived during validation, can be used in practice. Eight laboratories participated in this interlaboratory study. The set-up allowed the determination of the repeatability variance, s(2)r and the between-laboratory variance, s(2)L. Combination of s(2)r and s(2)L results in the reproducibility variance s(2)R. It has been shown how these data can be used in future by a single laboratory that wants to make an uncertainty statement concerning the same analysis. [less ▲]

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See detailDetermination of uncertainty in analytical measurements: Collaborative study of the analysis of phenoxymethylpenicillin
Dehouck, Pieter; Vander Heyden, Yvan; Smeyers-Verbecke, Johanna et al

Poster (2002, April)

Detailed reference viewed: 16 (1 ULg)