References of "Espinoza, C"
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See detailGross total resection or debulking of pituitary adenomas improves hormonal control of acromegaly by somatostatin analogs
Petrossians, Patrick ULg; Borges-Martins, L.; Espinoza, C. et al

in European Journal of Endocrinology (2005), 152(1), 61-66

Introduction: Invasive GH-secreting pituitary adenomas are rarely cured by surgery and although long-term therapy with somatostatin analogs (SSAs) may be employed, hormonal control is achieved in only 60 ... [more ▼]

Introduction: Invasive GH-secreting pituitary adenomas are rarely cured by surgery and although long-term therapy with somatostatin analogs (SSAs) may be employed, hormonal control is achieved in only 60% of cases. The impact of tumor debulking on subsequent control of acromegaly with SSAs has not been studied previously. Methods: We studied retrospectively the response to SSA therapy in acromegalic patients before and after incomplete surgical tumor excision. A case review identified 24 acromegalic patients who had received SSA therapy for 1 month before and after gross total resection or debulking of adenomas. No patient received radiotherapy or combination treatment with SSAs and dopamine agonists during the study. GH and IGF-I responses to SSAs were recorded pre- and postoperatively. Postoperative SSA therapy was begun after a washout period of 1–3 months to assess the hormonal effects of the surgery alone. Results: Before preoperative SSA treatment, 24/24 (100%) patients had elevated GH levels and IGF-I levels were elevated in 19/21 (90.5%) patients with recorded values. During preoperative SSA treatment, GH and IGF-I levels were normalized in 7/24 (29.2%) and 11/24 (45.8%) patients respectively. Following postoperative washout, GH was controlled in only 3/24 (12.5%) patients, while IGF-I was controlled in 8/19 (42.1%) patients with available data. During the second SSA treatment period, normal GH levels were seen in 13/24 (54.2%) patients, while IGF-I control was noted in 18/23 (78.3%). Conclusion: Gross total tumor resection or debulking increases the likelihood of achieving biochemical disease control with SSAs in acromegalic patients with adenomas that were not amenable to complete surgical resection and in whom primary SSA therapy was unable to achieve good biochemical control. [less ▲]

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See detailTemporal evolution of sediment supply in Lago Puyehue (Southern Chile) during the last 600 yr and its climatic significance
Bertrand, S.; Boes, X.; Castiaux, J. et al

in Quaternary Research (2005), 64(2), 163-175

Short-term climate changes in Southern Chile are investigated by a multi-proxy analysis of a 53-cm-long sedimentary sequence selected among eight short cores retrieved in Lago Puyehue (Chile, 40 degrees S ... [more ▼]

Short-term climate changes in Southern Chile are investigated by a multi-proxy analysis of a 53-cm-long sedimentary sequence selected among eight short cores retrieved in Lago Puyehue (Chile, 40 degrees S). This core contains a 600-yr-long undisturbed record of paleo-precipitation changes. Two measurement methods for sediment density, organic matter and biogenic silica contents are compared and the most appropriate techniques are selected. Together with aluminium and titanium concentrations, grain size and geochemical properties of the organic matter, these proxies are used to demonstrate paleo-precipitation changes around 40 degrees S. Increase of terrigenous particle supply between A.D. 1490 and A.D. 1700 suggests a humid period. Contemporaneously, delta C-13 data show increasing lake productivity, in response to the high nutrient supply. The A.D. 1700-1900 interval is characterized by a decreasing terrigenous supply and increasing delta C-13 values, interpreted as a drying period. The magnetic susceptibility signal, reflecting the terrigenous/biogenic ratio, demonstrates that similar variations occur in all the undisturbed sedimentary environments of Lago Puyehue. The A.D. 1490-1700 wet period is associated with the onset of the European Little Ice Age (LIA) and interpreted as its local signature. This work supports the fact that the LIA was a global event, not only restricted to the Northern Hemisphere. (c) 2005 University of Washington. All rights reserved. [less ▲]

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See detailLa réduction chirurgicale de la masse tumorale des adénomes hypophysaires améliore le contrôle médical de l'acromégalie par les analogues de la Somatostatine
Petrossians, Patrick ULg; Borges-Martins, L.; Espinoza, C. et al

in XXIème Congrès de la Société Française d'Endocrinologie - Abstract book (2004)

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