  "Real-life" effectiveness of omalizumab in patients with severe persistent allergic asthma: The PERSIST study.; ; Louis, Renaud  et alin Respiratory medicine (2009), 103(11), 1633-42 OBJECTIVE: To evaluate the 16- and 52-week effectiveness of add-on omalizumab treatment under real-life heterogeneity in patients, settings, and physicians in an open-label, multicenter, pharmaco ... [more ▼] OBJECTIVE: To evaluate the 16- and 52-week effectiveness of add-on omalizumab treatment under real-life heterogeneity in patients, settings, and physicians in an open-label, multicenter, pharmaco-epidemiologic study of patients with severe persistent allergic asthma in Belgium. METHODS: Effectiveness outcomes included improvement in 2005 global initiative for asthma (GINA) classification, physician-rated global evaluation of treatment effectiveness (GETE), quality of life (Juniper asthma-related quality of life (AQLQ) and European quality of life questionnaire 5 dimensions (EQ-5D)), and severe asthma exacerbations. Patients studied included both intent-to-treat and per-protocol populations. RESULTS: The sample (n=158) had a mean age of 48.17+/-17.18 years, and a slight majority were female (53.8%). Despite being treated with high-dose inhaled corticosteroids and long-acting beta2-agonists, all patients experienced frequent symptoms and had exacerbations in the past year. At 16 weeks, >82% had good/excellent GETE (P values <0.001), >82% had an improvement in total AQLQ scores of > or =0.5 points (P<0.001), and >91% were severe exacerbation-free (P<0.001). At 52 weeks, >72% had a good/excellent GETE rating (P<0.001), >84% had improvements in total AQLQ score of > or =0.5 points (P<0.001), >56% had minimally important improvements in EQ-5D utility scores (P=0.012), and >65% were severe exacerbation-free (P<0.001). Significant reductions in healthcare utilization compared to the one year prior to treatment were noted. CONCLUSION: The PERSIST study shows better physician-rated effectiveness, greater improvements in quality of life, greater reductions in exacerbation rates, and greater reductions in healthcare utilization than previously reported in efficacy studies. Under real-life conditions, omalizumab is effective as add-on therapy in the treatment of patients with persistent severe allergic asthma. [less ▲] Detailed reference viewed: 41 (5 ULg)Implementation of discharge management for geriatric patients at risk of readmission or institutionalization; ; et al in International Journal for Quality in Health Care (2006), 18(5), 352-358 Objective. To evaluate whether implementation of discharge management by trained social workers or nurses reduces hospital readmissions and institutionalizations of geriatric patients in a real-world ... [more ▼] Objective. To evaluate whether implementation of discharge management by trained social workers or nurses reduces hospital readmissions and institutionalizations of geriatric patients in a real-world setting. Design. Quasi-experimental design. Setting. Six general hospitals in Belgium. Participants. A representative sample of 824 patients, 355 of whom were assigned to the experimental group receiving comprehensive discharge management and 469 to the control group receiving usual care. Inclusion criteria were patients admitted to a geriatric, rehabilitation, or internal medicine ward, not residing in a nursing home, and showing risk of readmission or institutionalization on admission in the hospital. Intervention. In-hospital discharge planning according to a case management protocol allowing for adjustment to participating hospitals' case mix and patients' and families' specific needs. Main outcome measures. Hospital readmission within 15 and 90 days post discharge; institutionalization at discharge and within 15 and 90 days post discharge. Results. Discharge management resulted in fewer institutionalizations (n = 53; 14.9%) compared with usual care (n = 130; 23.7%) (adjusted odds ratio = 0.47; CI 95% = 0.31-0.70). Readmission rates between the intervention and usual care group were not significantly different. Conclusions. This implementation project showed that a discharge planning intervention can reduce institutionalization rates of elderly patients in real-life settings. [less ▲] Detailed reference viewed: 35 (2 ULg)Pilootproject : ontslagmanagement in Belgische ziekenhuizen. [Pilot study : discharge management in Belgian hospitals]. Final report, 2000; ; et al Report (2000) Detailed reference viewed: 8 (3 ULg)Pilootproject : Ontslagmanagement in Belgische Psyciatrische Ziekenhuizen. [Pilot study : discharge management in Belgian psychiatric hospitals]. Summarizing report, 2000; ; et al Report (2000) Detailed reference viewed: 1 (1 ULg)Pilootproject : Ontslagmanagement in Belgische Psyciatrische Ziekenhuizen. [Pilot study : discharge management in Belgian psychiatric hospitals]. Final report, 2000; ; et al Report (2000) Detailed reference viewed: 2 (1 ULg)Pilootproject : ontslagmanagement in Belgische ziekenhuizen. [Pilot study : discharge management in Belgian hospitals]. Summarizing report, 2000.; ; et al Report (2000) Detailed reference viewed: 2 (1 ULg)Etude pilote : Case management intégré dans les hôpitaux belges.; Dejace, Alain ; et alReport (1999) Detailed reference viewed: 20 (4 ULg)Case management : pilootproject case management in Belgische ziekenhuizen. [Case management : pilot study on case management in Belgian hospitals] . Final report, 1998; ; et al Report (1998) Detailed reference viewed: 7 (4 ULg)Case management : pilootproject case management in Belgische ziekenhuizen. [Case management : pilot study on case management in Belgian hospitals]. Summarizing report, 1998.; ; et al Report (1998) Detailed reference viewed: 7 (3 ULg)Case Management : a multidisciplinary approach to prevent institutionalization of high-risk elderly; ; et al Conference (1998) Case Management : Gestion de situations critiques pour personnes âgées à domicile.Dejace, Alain ; Gosset, Christiane ; et alReport (1998) Detailed reference viewed: 22 (0 ULg)Case Management voor geriatrische patienten en hun families : Het klinisch model van belgische projecten; ; et al in Tijdschrift voor de Geschiedenis der Geneeskunde, Natuurwetenschappen, Wiskunde en Techniek (1998), 54(6), 427-435 Detailed reference viewed: 19 (0 ULg)Case Management pour des patients psychogériatriques à domicileDejace, Alain ; Gosset, Christiane ; et alConference (1996) Detailed reference viewed: 1 (0 ULg)Case management en soins infirmiers auprès de patients psychogériatriques et leurs familles; Dejace, Alain ; Gosset, Christiane et alReport (1996) Detailed reference viewed: 25 (0 ULg)Case management voor psychogeriatrishe patiënten: theoritisch kader van een verpleegkundig demonstratieproject; ; Dejace, Alain et alin Acta Hospitalia (1996), 4 Detailed reference viewed: 17 (0 ULg)Case management voor psychogeriatrishe patiënten: de case manager; ; Dejace, Alain et alin Acta Hospitalia (1996), 4 Detailed reference viewed: 7 (0 ULg)Case management voor psychogeriatrishe patiënten: gezondheidstoestand van deze ouderen en de zorgbelasting van hun centrale verzorgers; ; Dejace, Alain et alin Acta Hospitalia (1996), 4 Detailed reference viewed: 22 (0 ULg)Case management en soins infirmiers chez des patients psychogériatriques vivant à domicileDejace, Alain ; Gosset, Christiane ; et alConference (1995) Detailed reference viewed: 3 (0 ULg) |
||
