PMID- 24733252
OWN - NLM
STAT- In-Process
DA  - 20141114
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 33
IP  - 12
DP  - 2014 Dec
TI  - The apoptosis of osteoblasts and osteocytes in femoral head osteonecrosis: its
      specificity and its distribution.
PG  - 1791-5
LID - 10.1007/s10067-014-2607-1 [doi]
AB  - The pathogenesis of nontraumatic osteonecrosis (ON) remains unclear. Some studies
      have suggested that nontraumatic ON is attributed to increased osteocytic
      apoptosis. To test this hypothesis, a controlled study must compare the apoptosis
      of osteocytes and osteoblasts in cases of ON and osteoarthritis (OA). To assess
      either the localized or diffuse patterns of this increased osteocytic and
      osteoblastic apoptosis, we evaluated both the proximal and distal regions of
      necrotic areas. Femoral heads resected for total hip prosthesis were included for
      this study. Of these, 10 were ON cases-three were induced by corticosteroids,
      three by alcohol abuse, one resulted from trauma, one resulted from hyperlipemia,
      and two were idiopathic-10 were osteoarthritis cases, and 1 from a patient
      suffering from a subcapital fracture. The TUNEL reaction was used to detect the
      apoptosis in osteoblasts and osteocytes. A semi-quantitative evaluation was
      conducted, at both distal and proximal areas relative to the lesions,
      specifically in the area surrounding the necrotic region in the osteonecrosis
      cases, in the eburnated bone in the osteoarthritis cases, and in the subchondral 
      bone fracture. The apoptosis of osteoblasts and osteocytes was statistically more
      frequent in the regions close to the necrotic areas in the ON group. No
      difference was found in the unpaired areas. In the ON group, no difference was
      found in terms of the etiological factors. During ON, the apoptosis of osteocytes
      and osteoblasts is increased proximally to the necrotic regions in the patients
      presenting with osteoarthritis and subcapital fractures. This increase was found 
      not only in the corticosteroid-induced ON cases but also in the idiopathic and
      alcohol abuse- and trauma-induced ON cases.
FAU - Mutijima, Eugene
AU  - Mutijima E
AD  - Department of Pathology, CHU Sart Tilman, Sart Tilman, 4000, Liege, Belgium,
      E.Mutijima@chu.ulg.ac.be.
FAU - De Maertelaer, Viviane
AU  - De Maertelaer V
FAU - Deprez, Manu
AU  - Deprez M
FAU - Malaise, Michel
AU  - Malaise M
FAU - Hauzeur, Jean-Philippe
AU  - Hauzeur JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140415
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
SB  - IM
EDAT- 2014/04/16 06:00
MHDA- 2014/04/16 06:00
CRDT- 2014/04/16 06:00
PHST- 2014/02/23 [received]
PHST- 2014/03/30 [accepted]
PHST- 2014/04/15 [aheadofprint]
AID - 10.1007/s10067-014-2607-1 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2014 Dec;33(12):1791-5. doi: 10.1007/s10067-014-2607-1. Epub 2014
      Apr 15.